免疫细胞与新生儿坏死性小肠结肠炎病情进展的相关性研究

Study on the Correlation between Immune Cells and the Progression of Neonatal Necrotizing Enterocolitis

摘要: 新生儿坏死性小肠结肠炎(Necrotizing Enterocolitis, NEC)是一种危及新生儿生命的肠道疾病，影响约5%~10%的出生体重 < 1500 g的早产儿，死亡率从15%~30%不等，后遗症的发生率约为25%。NEC的早期症状不典型，临床难以早期诊断，目前难以获得“理想的”预测和诊断NEC的实验室检查指标和生物标记物，免疫细胞成为研究的一个热点。患儿的免疫功能状态与NEC的发生、发展和预后密切相关。NLR、PLR、MLR与NEC的病情进展相关，有助于评估NEC的严重程度和病情演变过程。

Abstract: Neonatal necrotizing enterocolitis (NEC) is a life-threatening intestinal disease affecting about 5%~10% of premature infants whose birth weight is less than 1500 g, the mortality varies from 15% to 30%, and the incidence of sequelae is about 25%. The early symptoms of NEC are not typical, and it is difficult to diagnose early in clinic. At present, it is difficult to obtain “ideal” laboratory indexes and biomarkers for predicting and diagnosing NEC. Immune cells have become a hot spot of re-search. The immune function of children is closely related to the occurrence, development and prognosis of NEC. NLR, PLR and MLR are related to the progression of NEC, which is helpful to evalu-ate the severity and evolution of NEC.