多种炎症标志物预测脓毒症相关急性肾损伤研究进展
Research Progress on Predicting Sepsis Related Acute Kidney Injury Using Multiple Inflammatory Markers
DOI: 10.12677/ACM.2023.13122696, PDF,   
作者: 边星苹, 张 丽：新疆医科大学第一附属医院肾脏病中心，新疆 乌鲁木齐
关键词: 炎症标志物；脓毒症；急性肾损伤；Inflammatory Markers； Sepsis； Acute Kidney Injury
摘要: 在重症病房中，脓毒症是一种常见的疾病，而在由脓毒症所导致的多脏器功能衰竭中，急性肾损伤(AKI)较为常见，而其对于患者生存状况的影响和打击也不容小觑，脓毒症和急性肾损伤二者相互促进，因此尽早识别脓毒症相关急性肾损伤的发生，尽早行干预治疗以提高患者生存率及生活质量则尤为重要。为达到此目标，有多种炎症标志物发挥了巨大作用。它们不仅能预测脓毒症相关肾损伤的发生，甚至还与其预后相关，本文即对以上内容做文献综述。
Abstract: Sepsis is a common disease in intensive care units, and acute kidney injury (AKI) is more common in multiple organ failure caused by sepsis. Its impact and impact on patient survival cannot be un-derestimated. Sepsis and acute kidney injury promote each other, so early identification of sepsis related acute kidney injury occurs, and early intervention therapy is particularly important to im-prove patient survival and quality of life. To achieve this goal, various inflammatory markers have played a significant role. They can not only predict the occurrence of sepsis related kidney injury, but also be related to its prognosis. This article will provide a literature review on the above con-tent.
文章引用：边星苹, 张丽. 多种炎症标志物预测脓毒症相关急性肾损伤研究进展[J]. 临床医学进展, 2023, 13(12): 19162-19167. https://doi.org/10.12677/ACM.2023.13122696

参考文献

[1] Liu, J., Xie, H., Ye, Z., et al. (2020) Rates, Predictors, and Mortality of Sepsis-Associated Acute Kidney Injury: A Sys-tematic Review and Meta-Analysis. BMC Nephrology, 21, Article No. 318. [Google Scholar] [CrossRef] [PubMed]
[2] Singer, M., Deutschman, C.S., Seymour, C.W., et al. (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315, 801-810. [Google Scholar] [CrossRef] [PubMed]
[3] Parmar, A., Langenberg, C., Wan, L., et al. (2009) Epidemiology of Septic Acute Kidney Injury. Current Drug Targets, 10, 1169-1178. [Google Scholar] [CrossRef] [PubMed]
[4] Peerapornratana, S., Manrique-Caballero, C.L., Gomez, H., et al. (2019) Acute Kidney Injury from Sepsis: Current Concepts, Epidemiology, Pathophysiology, Prevention and Treat-ment. Kidney International, 96, 1083-1099. [Google Scholar] [CrossRef] [PubMed]
[5] Mehta, R.L., Bouchard, J., Soroko, S.B., et al. (2011) Sepsis as a Cause and Consequence of Acute Kidney Injury: Program to Improve Care in Acute Renal Disease. Intensive Care Med-icine, 37, 241-248. [Google Scholar] [CrossRef] [PubMed]
[6] Levy, E.M., Viscoli, C.M. and Horwitz, R.I. (1996) The Effect of Acute Renal Failure on Mortality. A Cohort Analysis. JAMA, 275, 1489-1494. [Google Scholar] [CrossRef] [PubMed]
[7] Thakar, C.V., Yared, J.P., Worley, S., et al. (2003) Renal Dysfunc-tion and Serious Infections after Open-Heart Surgery. Kidney International, 64, 239-246. [Google Scholar] [CrossRef] [PubMed]
[8] Kuwabara, S., Goggins, E. and Okusa, M.D. (2022) The Pathophysiology of Sepsis-Associated AKI. Clinical Journal of the American Society of Nephrology, 17, 1050-1069. [Google Scholar] [CrossRef] 
[9] Brenner, M., Schaer, G.L., Mallory, D.L., et al. (1990) Detection of Renal Blood Flow Abnormalities in Septic and Critically Ill Patients Using a Newly Designed Indwelling Thermodilution Renal Vein Catheter. Chest, 98, 170-179. [Google Scholar] [CrossRef] [PubMed]
[10] 罗涛, 雷蕾, 蒋瑾瑾. SAA在固有免疫防御感染中的作用机制[J]. 中国免疫学杂志, 2021, 37(12): 1533-1536.
[11] Gouwy, M., De Buck, M., Portner, N., et al. (2015) Serum Amyloid A Chemoattracts Immature Dendritic Cells and Indirectly Provokes Monocyte Chemotaxis by Induction of Cooperating CC and CXC Chemokines. European Journal of Immunology, 45, 101-112. [Google Scholar] [CrossRef] [PubMed]
[12] De Buck, M., Berghmans, N., Portner, N., et al. (2015) Serum Amyloid A1alpha Induces Paracrine IL-8/CXCL8 via TLR2 and Directly Synergizes with This Chemokine via CXCR2 and Formyl Peptide Receptor 2 to Recruit Neutrophils. Journal of Leukocyte Biology, 98, 1049-1060. [Google Scholar] [CrossRef] 
[13] Akin, H., Akalin, H., Budak, F., et al. (2015) Alterations of Serum Cytokine Levels and Their Relation with Inflammatory Markers in Candidemia. Medical Mycology, 53, 258-268. [Google Scholar] [CrossRef] [PubMed]
[14] 高榕悦, 韩玉珍, 李文雄, 等. 钙卫蛋白与脓毒症关系研究进展[J]. 中国急救医学, 2022, 42(1): 87-91.
[15] Kang, K.Y., Woo, J.W. and Park, S.H. (2014) S100A8/A9 as a Biomarker for Synovial Inflammation and Joint Damage in Patients with Rheumatoid Arthritis. The Korean Journal of Internal Medi-cine, 29, 12-19. [Google Scholar] [CrossRef] [PubMed]
[16] Lipcsey, M., Hanslin, K., Stalberg, J., et al. (2019) The Time Course of Calprotectin Liberation from Human Neutrophil Granulocytes after Escherichia coli and Endotoxin Challenge. Innate Immunity, 25, 369-373. [Google Scholar] [CrossRef] [PubMed]
[17] Thames, B.E., Barr, J.W., Suchodolski, J.S., et al. (2019) Pro-spective Evaluation of S100A12 and S100A8/A9 (Calprotectin) in Dogs with Sepsis or the Systemic Inflammatory Re-sponse Syndrome. Journal of Veterinary Diagnostic Investigation, 31, 645-651. [Google Scholar] [CrossRef] [PubMed]
[18] Gao, S., Yang, Y., Fu, Y., et al. (2015) Diagnostic and Prognos-tic Value of Myeloid-Related Protein Complex 8/14 for Sepsis. The American Journal of Emergency Medicine, 33, 1278-1282. [Google Scholar] [CrossRef] [PubMed]
[19] Zhang, L.N., Wang, X.H., Wu, L., et al. (2016) Diag-nostic and Predictive Levels of Calcium-Binding Protein A8 and Tumor Necrosis Factor Receptor-Associated Factor 6 in Sepsis-Associated Encephalopathy: A Prospective Observational Study. Chinese Medical Journal (England), 129, 1674-1681. [Google Scholar] [CrossRef] [PubMed]
[20] 钱骏, 徐建如, 葛志华, 等. 血、尿钙卫蛋白对脓毒症患者并发急性肾损伤的早期诊断价值[J]. 临床合理用药杂志, 2019, 12(22): 133-134.
[21] Wang, C., Zhang, J., Han, J., et al. (2017) The Level of Urinary IL-18 in Acute Kidney Injury after Cardiopulmonary Bypass. Experimental and Therapeutic Medicine, 14, 6047-6051. [Google Scholar] [CrossRef] [PubMed]
[22] Malik, A. and Kanneganti, T.D. (2017) Inflammasome Activation and Assembly at a Glance. Journal of Cell Science, 130, 3955-3963. [Google Scholar] [CrossRef] [PubMed]
[23] Hawkins, R. (2011) New Biomarkers of Acute Kidney Injury and the Car-dio-Renal Syndrome. The Korean Journal of Laboratory Medicine, 31, 72-80. [Google Scholar] [CrossRef] [PubMed]
[24] 陈贵艳, 张鹏飞, 周大鹏, 等. 白介素-17及降钙素原与脓毒症的相关性研究[J]. 河北医学, 2016, 22(11): 1850-1852.
[25] 王志高, 唐雯, 张大权, 等. 白细胞介素-17水平对脓毒症患者发生急性肾损伤的预测价值[J]. 中华实用诊断与治疗杂志, 2021, 35(1): 48-51.
[26] 许英珠, 文晓宏, 卢运生. 血清IL-17、IL-18联合检测对脓毒症并发急性肾损伤的诊断价值[J]. 临床与病理杂志, 2022, 42(12): 2884-2889.
[27] Zahorec, R. (2017) Neutrophil-to-Lymphocyte Ratio. Sixteen-Year-Long History since Publication of Our Article in Bratislava Medical Journal. Bratislavské Lekárske Listy, 118, 321-323. [Google Scholar] [CrossRef] 
[28] 李平, 王东, 代小雨, 等. NLR和PLR以及CAR联合血清胱抑素C对急性胰腺炎合并急性肾损伤的预测价值[J]. 临床急诊杂志, 2021, 22(9): 592-596.
[29] Koupenova, M., Clancy, L., Corkrey, H.A., et al. (2018) Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis. Circula-tion Research, 122, 337-351. [Google Scholar] [CrossRef] 
[30] Cho, S.K., Jung, S., Lee, K.J., et al. (2018) Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio Can Predict the Severity of Gall-stone Pancreatitis. BMC Gastroenterology, 18, Article No. 18. [Google Scholar] [CrossRef] [PubMed]
[31] 王猛. 血小板与淋巴细胞比值和单核细胞与淋巴细胞比值预测脓毒症患者发生急性肾损伤的价值[D]: [硕士学位论文]. 青岛: 青岛大学, 2021.
[32] Seringec, A.N., Yildirim, C.G., Gogebakan, H., et al. (2019) The C-Reactive Protein/Albumin Ratio and Complete Blood Count Parameters as In-dicators of Disease Activity in Patients with Takayasu Arteritis. Medical Science Monitor, 25, 1401-1409. [Google Scholar] [CrossRef] 
[33] Ugurlu, E.T. and Tercan, M. (2022) The Role of Biomarkers in the Early Diagnosis of Acute Kidney Injury Associated with Acute Pancreatitis: Evidence from 582 Cases. Ulusal Travma ve Acil Cerrahi Dergisi, 29, 81-93. [Google Scholar] [CrossRef] [PubMed]
[34] Ranzani, O.T., Zampieri, F.G., Forte, D.N., et al. (2013) C-Reactive Protein/Albumin Ratio Predicts 90-Day Mortality of Septic Patients. PLOS ONE, 8, e59321. [Google Scholar] [CrossRef] [PubMed]
[35] Liu, B. and Lv, D. (2023) Prognostic Value of C-Reactive Pro-tein to Albumin Ratio for Mortality in Acute Kidney Injury. BMC Nephrology, 24, Article No. 44. [Google Scholar] [CrossRef] [PubMed]

为你推荐