中西医对于高原低压低氧脑损伤研究进展
Research Progress of Traditional Chinese and Western Medicine on High-Altitude Hypobaric and Hypoxic Brain Injury
DOI: 10.12677/ACM.2023.13122704, PDF,   
作者: 李云頔, 李永平*:青海大学中医系,青海 西宁 ;杨 澜:龙口市城市社区卫生服务中心中医科,山东 烟台
关键词: 高原低压低氧脑损伤中医针灸神经细胞凋亡High-Altitude Hypobaric Hypoxic Brain Injury Chinese Medicine Acupuncture Nerve Cell Apoptosis
摘要: 随着西部大开发战略推进和西北旅游业的蓬勃发展,选择进入高原的人越来越多,如何提前预防出现急进高原低压低氧脑损伤以及如何治疗成为了目前不可忽视的问题。本文通过总结高原低氧脑损伤的现代及传统医学研究现状,以期为如何预防及减轻高原低压低氧脑损伤提供思路。
Abstract: With the promotion of the western development strategy and the vigorous development of tourism in the northwest, more and more people choose to enter the plateau, and how to prevent the occur-rence of cerebral injury with low pressure and hypoxia in the plateau and how to treat it in advance have become problems that cannot be ignored at present. This article summarizes the current sta-tus of modern and traditional medical research on high-altitude hypoxic brain injury, in order to provide ideas for how to prevent and alleviate high-altitude hypoxic brain injury.
文章引用:李云頔, 杨澜, 李永平. 中西医对于高原低压低氧脑损伤研究进展[J]. 临床医学进展, 2023, 13(12): 19214-19218. https://doi.org/10.12677/ACM.2023.13122704

参考文献

[1] Li, Y.P., Li, M.X., Wang, C., et al. (2023) Bloodletting Acupuncture at Jing-Well Points on Hand Induced Autophagy to Alleviate Brain Injury in Acute Altitude Hypoxic Rats by Activating PINK1/Parkin Pathway. Chinese Journal of Inte-grative Medicine, 29, 932-940. [Google Scholar] [CrossRef] [PubMed]
[2] Luks, A.M., Swenson, E.R. and Bärtsch, P. (2017) Acute High-Altitude Sickness. European Respiratory Review, 26, Article ID: 160096. [Google Scholar] [CrossRef] [PubMed]
[3] Irons, H.R., Salas, R.N., Bhai, S.F., et al. (2020) Prospective Double-Blinded Randomized Field-Based Clinical Trial of Metoclopramide and Ibuprofen for the Treatment of High Al-titude Headache and Acute Mountain Sickness. Wilderness & Environmental Medicine, 31, 38-43. [Google Scholar] [CrossRef] [PubMed]
[4] 郭丽红, 陈辉, 张燕, 等. CT灌注成像联合血清microRNA-493预测急性脑梗死患者预后的价值[J]. 中国现代医学杂志, 2023, 33(22): 88-93.
[5] Li, J., Tang, B.Z., Qu, Y. and Mu, D.Z. (2011) Telomerase Reverse Transcriptase: A Novel Neuroprotective Mechanism Involved in Neonatal Hypoxic-Ischemic Brain Injury. International Journal of Developmental Neuroscience, 29, 867-872. [Google Scholar] [CrossRef] [PubMed]
[6] 谢集建. 缺氧缺血性脑损伤的发病机制研究进展[J]. 国外医学(妇幼保健分册), 2002, 13(1): 30-32.
[7] Gou, Z.X., Su, X.J., Hu, X., et al. (2020) Melatonin Improves Hypox-ic-Ischemic Brain Damage through the Akt/Nrf2/Gpx4 Signaling Pathway. Brain Research Bulletin, 15, 40-48. [Google Scholar] [CrossRef] [PubMed]
[8] 王颖. 半通道开放对缺血再灌注海马神经元活性的影响[D]: [硕士学位论文]. 杭州: 浙江大学, 2007.
[9] Modesti, P.A., Rapi, S., Paniccia, R., et al. (2011) Index Measured at an Intermediate Altitude to Predict Impending Acute Mountain Sickness. Medicine & Science in Sports & Exercise, 43, 1811-1818. [Google Scholar] [CrossRef
[10] 霍妍, 赵安鹏, 李雪, 等. 急性高原病的动物模型研究现状[J]. 中国药理学通报, 2021, 37(1): 26-30.
[11] Jiang, W., Tang, Y.Y., Zhu, W.W., et al. (2021) PI3K/AKT Pathway Mediates the Antidepressant-and Anxiolytic-Like Roles of Hydrogen Sulfide in Streptozotocin-Induced Diabetic Rats via Promoting Hippocampal Neurogenesis. Neurotoxicology, 85, 201-208. [Google Scholar] [CrossRef] [PubMed]
[12] Ma, N., Zhao, Z.A., Zhang, N.N. and Chen, H.S. (2018) In-tra-Arterial Human Urinary Kallidinogenase Alleviates Brain Injury in Rats with Permanent Middle Cerebral Artery Oc-clusion through PI3K/AKT/FoxO1 Signaling Pathway. Brain Research, 1687, 129-136. [Google Scholar] [CrossRef] [PubMed]
[13] Chen, N.Y., Lu, K., Yuan, J.M., et al. (2021) 3-Arylamino-Quinoxaline-2-Carboxamides Inhibit the PI3K/Akt/mTOR Signaling Pathways to Activate P53 and Induce Apoptosis. Bioorganic Chemistry, 114, Article ID: 105101. [Google Scholar] [CrossRef] [PubMed]
[14] 王妍, 万莹, 冯士春, 等. AZGP1在老年结直肠癌患者中的预后价值及其下调后对结直肠癌细胞的影响[J]. 胃肠病学和肝病学杂志, 2021, 30(8): 859-867.
[15] 王丽欣. 锂匹鲁卡品致痫大鼠海马神经元Bax、Caspase-3蛋白和PI3K/Akt的变化及灵芝酸的干预[D]: [硕士学位论文]. 佳木斯: 佳木斯大学, 2015.
[16] Gong, G., Yin, L., Yuan, L.B., et al. (2018) Ganglioside GM1 Protects against High Altitude Cerebral Edema in Rats by Suppressing the Oxidative Stress and Inflammatory Response via the PI3K/AKT-Nrf2 Pathway. Molecular Immunology, 95, 91-98. [Google Scholar] [CrossRef] [PubMed]
[17] Hou, G.Q., Zhao, Q., Zhang, M.Y., et al. (2018) Down-Regulation of Rictor Enhances Cell Sensitivity to PI3K Inhibitor LY294002 by Blocking mTORC2-Medicated Phosphorylation of Akt/PRAS40 in Esophageal Squamous Cell Carcinoma. Biomedicine & Pharmacotherapy, 106, 1348-1356. [Google Scholar] [CrossRef] [PubMed]
[18] Li, Y.H., Zhang, Y.J. and Zhang, Y. (2018) Re-search Advances in Pathogenesis and Prophylactic Measures of Acute High Altitude Illness. Respiratory Medicine, 11, 145-152. [Google Scholar] [CrossRef] [PubMed]
[19] 孔晓婷, 汪元汲, 沈国双, 杨惠. 高原低氧环境对人体的影响及药物干预研究进展[J]. 现代医药卫生, 2022, 38(9): 1523-1527.
[20] 黎洁, 李永平, 朱港星. 基于网络药理学研究补阳还五汤治疗急性高原低氧性脑损伤的作用机制[J]. 环球中医药, 2023, 16(5): 889-897.
[21] 朱俐, 石仲瑗, 吴小梅, 等. 人参银杏合剂对抗大鼠脑急性低氧损伤的作用[J]. 中国临床药理学与治疗学, 2004, 9(9): 1041-1044.
[22] 黄倩茹, 董亚琴, 潘晓华, 萨喆燕, 周丽莉, 许金森. 电针长强穴对缺血缺氧脑损伤仔鼠学习记忆能力及海马PI3K、Akt蛋白表达的影响[J]. 中华中医药杂志, 2022, 37(1): 416-419.
[23] 张英英, 单海军, 郭鑫. 针刺对缺氧缺血性脑损伤新生大鼠的神经保护作用及对小胶质细胞和炎症反应的影响[J]. 中国免疫学杂志, 2020, 36(2): 169-173.
[24] 胡晓丽. 输合配穴针刺干预脑损伤S100B、NSE等表达及神经修复的机制研究[D]: [博士学位论文]. 沈阳: 辽宁中医药大学, 2014.
[25] 黄雅倩, 李梦馨, 王超, 等. 井穴放血对急性高原缺氧脑损伤大鼠海马线粒体自噬相关蛋白表达的影响[J]. 针刺研究, 2021, 46(4): 301-305. [Google Scholar] [CrossRef] [PubMed]
[26] 李梦馨, 王超, 童丽, 等. 基于PI3K/AKT/mTOR信号通路探讨井穴放血对急性高原低氧脑损伤的保护作用[J/OL]. 世界科学技术-中医药现代化: 1-9, 2023-10-29. http://kns.cnki.net/kcms/detail/11.5699.R.20230915.0921.004.html
[27] 马婕, 崔森, 冀林华, 等. 高原红细胞增多症发病基因的研究进展[J]. 山东医药, 2017, 57(10): 112-114.
[28] 常德辉, 孔飞燕, 姜卫, 等. 高原低压低氧雄性Wistar大鼠生殖系统损伤模型的建立[J]. 中华男科学杂志, 2020, 26(12): 1068-1073.