妊娠期高血压疾病合并肾损害的早期诊断研究

Early Diagnosis Study of Hypertensive Diseases Combined with Renal Damage in Pregnancy

摘要: 目的：研究妊娠期高血压疾病患者血清中β2微球蛋白(β2.MG)、胱抑素C (CysC)的表达及二者联合检测对早期诊断妊娠期高血压疾病合并肾损害的价值。方法：选取我院2019年2月~2021年2月收治的125例妊娠期高血压疾病患者为研究对象(实验组)，依据病情轻重程度分为：41例轻度组、53例中度组、31例重度组；以肾小球滤过率(GFR)作为参考指标，分为：86例肾功能正常组、39例肾功能损害组；另选，同期118例在我院产检正常孕妇作为对照组。比较各组患者血清中β2.MG和CysC的表达及二者联合检测对早期诊断妊娠期高血压疾病合并肾损害的价值。结果：针对患者血清中的β2.MG和CysC的表达，实验组高于对照组(P < 0.05)；重度组依次高于中度组和轻度组(P < 0.05)；其合并肾功能损害组高于肾功能正常组(P < 0.05)。ROC曲线显示：妊娠期高血压疾病合并肾损害的患者血清中β2.MG、CysC及二者联合检测，其曲线下面积分别为0.713、0.765和0.903，二者联合检测曲线下面积大于单个指标。结论：妊娠期高血压疾病合并肾损害患者血清中β2.MG和CysC的表达上升，两项指标联合检测可提高诊断的准确性，从而早期诊断及干预，以控制病情进展和改善妊娠结局。

Abstract: Objective: To study the expression of β2 microglobulin (β2.MG) and Cystatin C (CysC) in the serum of hypertensive patients in pregnancy for the early diagnosis of hypertension combined with renal damage in pregnancy. Methods: 125 patients with gestational hypertension admitted from Febru-ary 2019 to February 2021 were selected as the study group (experimental group): 41 mild, 53 moderate and 31 severe groups; 86 filtration (GFR) and 39 renal impairment; respectively, 118 pregnant women with normal maternal examination in our hospital as the control group. The ex-pression of β2.MG and CysC in the serum of each group and the value of the combined test for the early diagnosis of hypertension in pregnancy combined with renal damage. Results: For the expres-sion of β2.MG and CysC in the patient serum, the experimental group was higher than the control group (P < 0.05). The severe group was successively higher than the moderate group and the mild group (P < 0.05), and the combined renal impairment group was higher than the normal renal function group (P < 0.05). The ROC curve showed that β2.MG, CysC and the serum of patients with gestational hypertensive disease and renal damage were jointly tested, and the area under the curve was 0.713, 0.765 and 0.903, respectively. The area under the combined test curve was great-er than a single index. Conclusion: The expression of β2.MG and CysC increased in the serum of pa-tients with hypertensive damage during pregnancy. Combined combination of the two indicators can improve the accuracy of diagnosis, thus having early diagnosis and intervention to control dis-ease progression and improve pregnancy outcome.