脑肿瘤相关癫痫发病机制的研究进展
Research Progress on the Pathogenesis of Brain Tumor Related Epilepsy
DOI: 10.12677/ACM.2023.13122712, PDF,   
作者: 焦 菲:青海大学研究生院,青海 西宁;祝增金:海东市第二人民医院,青海 海东;王兰桂*:青海大学附属医院神经内科,青海 西宁
关键词: 脑肿瘤癫痫发病机制Brain Tumor Epilepsy Pathogenesis
摘要: 痫性发作是脑肿瘤患者最常见的症状。脑肿瘤和癫痫之间有着共同的遗传、分子和细胞学机制。脑肿瘤相关癫痫的发病机制可能与神经元兴奋性传递增强、抑制性传递受损、丝氨酸/苏氨酸激酶(B-Raf proto-oncogene, serine/threonine kinase, BRAF)、异柠檬酸脱氢酶(Isocitrate Dehydrogenase, IDH)和磷脂酰肌醇3-激酶(Phosphatidylinositol 3-kinase, PIK3CA)的遗传突变、炎症、血液动力学损伤和星形胶质细胞功能障碍有关。本文旨在阐述脑肿瘤相关癫痫的发病机制以期发现新的靶点研究新的抗癫痫药。
Abstract: Epileptic seizures are the most common symptom in patients with brain tumors. There is a common genetic, molecular, and cellular mechanism between brain tumors and epilepsy. The pathogenesis of brain tumor related epilepsy may be related to increased neuronal excitatory transmission, im-paired inhibitory transmission, genetic mutations in serine/threonine kinase and phosphatidylino-sitol 3-kinase, inflammation, hemodynamic damage, and astrocyte dysfunction. This article aims to elucidate the pathogenesis of brain tumor related epilepsy, with the aim of discovering new targets and researching new anti epileptic drugs.
文章引用:焦菲, 祝增金, 王兰桂. 脑肿瘤相关癫痫发病机制的研究进展[J]. 临床医学进展, 2023, 13(12): 19265-19270. https://doi.org/10.12677/ACM.2023.13122712

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