原发免疫性血小板减少症患者细胞因子变化研究进展

Research Progress of Cytokine Changes in Patients with Primary Immune Thrombocytopenia

摘要: 原发免疫性血小板减少症在临床中比较常见。本病的发生机制比较复杂，多种细胞因子参与到了原发免疫性血小板减少症患者疾病的发生以及发展过程中。文章分为四个方面，深入性分析原发免疫性血小板减少症患者细胞因子变化情况。首先阐述了中国原发免疫性血小板减少症最新流行病学调查情况；其次分析了原发免疫性血小板减少症发病机理相关研究详情；再次探讨了原发免疫性血小板减少症患者细胞因子变化研究现状，其中包含IL-1β、IL-23、IL-17、IL-22，并分析了IL-17/IL-17R是否参与B细胞活化导致原发免疫性血小板减少症疾病发生研究情况；最后，对原发免疫性血小板减少症患者细胞因子变化研究前景以及相关展望加以总结。期望经此文，能够为相关人员的研究工作提供参考文献。

Abstract: Primary immune thrombocytopenia is common in clinical practice. The pathogenesis of this disease is complex, and a variety of cytokines are involved in the occurrence and development of the dis-ease in patients with primary immune thrombocytopenia. This article is divided into four aspects, with in-depth analysis of the changes of cytokines in patients with primary immune thrombocyto-penia. First, the latest epidemiological investigation of primary immune thrombocytopenia in China was reviewed. Secondly, the pathogenesis of primary immune thrombocytopenia was analyzed in detail. Again, the current status of cytokine changes in patients with primary immune thrombocy-topenia was discussed, including IL-1β, IL-23, IL-17, and IL-22, and whether IL-17/IL-17R was in-volved in B cell activation leading to primary immune thrombocytopenia was analyzed. Finally, the prospects of cytokine changes in patients with primary immune thrombocytopenia and related prospects were summarized. It is expected that this paper can provide references for the research work of relevant personnel.