Eph家族受体在机体生理和病理过程中作用机制的研究进展

Research Progress on the Mechanism of Action of Eph Family Receptors in Physiological and Pathological Processes of the Body

摘要: 促红细胞生成素肝细胞激酶(Erythropoietin-producing hepatocellular, Eph)受体家族作为目前已知最大的酪氨酸激酶受体家族，通过受体–配体结合，介导人类从胚胎发育到成人组织稳态诸多生物学功能的调节，参与机体各种免疫反应。研究发现，Eph受体在包括神经系统发育、细胞迁移、血管形成等许多生理发育过程中起重要作用，在调节免疫反应、肿瘤、炎症、损伤修复等病理过程中也发挥着重要功能。进一步深入的研究Eph家族受体的生物学功能能够更好的对临床疾病进行预防、诊断和治疗，了解调控Eph表达的转录和转录后机制在生物学上具有深远的意义。本篇综述通过从Eph受体家族参与神经发育调节、血管形成、介导免疫反应等方面探讨其在机体生理和病理中的作用机制，总结其在不同机体反应中的作用规律，对临床疾病的诊断、治疗等进一步提供新思路。

Abstract: The Erythropoietin-producing hepatocellular kinase receptor family, as the largest tyrosine kinase receptor family known to date, mediates the regulation of many biological functions from embryon-ic development to adult tissue homeostasis and participates in a variety of immune responses through receptor-ligand binding. It has been found that Eph receptors play important roles in many physiological developmental processes, including nervous system development, cell migration, and blood vessel formation, as well as in the regulation of immune responses, tumors, inflammation, and damage repair. Further in-depth study of the biological functions of the Eph family of receptors can lead to better prevention, diagnosis and treatment of clinical diseases, and understanding the tran-scriptional and post-transcriptional mechanisms that regulate the expression of Eph has far-reaching significance in biology. In this review, we explore the mechanism of Eph receptors in the physiology and pathology of the body from the aspects of their participation in neurodevelop-mental regulation, angiogenesis, and mediation of immune response, and summarize the rules of their roles in different body responses, which will further provide new ideas for the diagnosis and treatment of clinical diseases.