粪肠球菌在难治性根尖周炎炎症反应中的研究进展
Research Progress of Enterococcus faecalis in Inflammatory Response in Refractory Apical Periodontitis
DOI: 10.12677/ACM.2023.13122752, PDF,    科研立项经费支持
作者: 关 镕：新疆医科大学研究生院，新疆 乌鲁木齐 ；赵 莉*, 马依热·阿布都赛麦提：新疆维吾尔自治区人民医院口腔科，新疆 乌鲁木齐
关键词: 粪肠球菌；难治性根尖周炎；持续性根尖周炎；脂磷壁酸；巨噬细胞；IL-1；IL-1β；Treg细胞；Enterococcus faecalis； Refractory Apical Periodontitis； Persistent Apical Periodontitis； Lipoteichoic Acid； Macrophages； IL-1； IL-1β； Treg Cells
摘要: 粪肠球菌作为难治性根尖周炎的主要致病菌，能够在恶劣环境中形成粘附力极强的生物膜而长期生存，对氢氧化钙等根管消毒药物和机械清理具有抵抗性，是感染根管治疗失败的主要原因。因此，粪肠球菌已成为牙髓病学领域最近的研究重点。粪肠球菌的致病性主要表现在细菌侵入根尖周组织后激活机体免疫反应，激活RIPK3/MLKL信号通路并诱导巨噬细胞凋亡从而分泌细胞因子发挥抗炎和抑炎作用，造成根尖周组织的持续炎症，也会引发全身多种器官感染。本文就粪肠球菌在难治性根尖周炎中的致病性相关机制做一综述。
Abstract: As the main pathogenic bacteria in the root canal of refractory apical periodontitis, Enterococcus faecalis can survive for a long time in harsh environments to form biofilms with strong adhesion, and is resistant to root canal disinfection drugs such as calcium hydroxide and mechanical cleaning, which is the main reason for the failure of infection root canal treatment. The pathogenicity of En-terococcus faecalis is mainly manifested in the activation of the body’s immune response after the bacteria invade the periapical tissue, initiating the Th17/Treg cell pathway and inducing apoptosis of macrophages to secrete cytokines to exert anti-inflammatory and anti-inflammatory effects, re-sulting in continuous inflammation of periapical tissues, and eventually causing multiple organ in-fections throughout the body. This article reviews the pathogenicity-related mechanism of Entero-coccus faecalis in refractory apical periodontitis.
文章引用：关镕, 赵莉, 马依热·阿布都赛麦提. 粪肠球菌在难治性根尖周炎炎症反应中的研究进展[J]. 临床医学进展, 2023, 13(12): 19547-19553. https://doi.org/10.12677/ACM.2023.13122752

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