酰胺质子转移加权成像对肿瘤的研究进展
Research Progress on Tumor by Weighted Imaging of Amide Proton Transfer
DOI: 10.12677/ACM.2023.13122756, PDF,   
作者: 向绪洋, 林慧婷：甘肃中医药大学第一临床医学院，甘肃 兰州；李孝忠*：甘肃中医药大学附属医院医学影像中心核磁室，甘肃 兰州
关键词: 酰胺质子转移；化学交换饱和转移；肿瘤；磁共振成像；Amide Proton Transfer； Chemical Exchange Saturation Transfer； Tumor； Magnetic Resonance Imaging
摘要: 酰胺质子转移加权成像(Amide Proton Transfer Weighted, APTw)是一致化学交换饱和技术(Chemical Exchange Saturation Transfer, CEST)的亚型，它是一种新型的分子磁共振成像技术。该技术主要基于细胞蛋白和组织中内源性多肽生成图像对比度，间接反映细胞的代谢及生理病理变化。目前APTw成像已经在多种肿瘤成像方面表现出良好的发展前景，特别在脑肿瘤和肿瘤治疗方面的应用显示出较大的优势。本文旨在描述APTw成像的基本原理及APTw成像在肿瘤中的研究现状、缺陷及前景。
Abstract: Amide proton transfer weighted imaging (APTw) is a subtype of chemical exchange saturation transfer (CEST) and a novel molecular magnetic resonance imaging technique. This technology is mainly based on the contrast of images generated by endogenous peptides in cell proteins and tis-sues, indirectly reflecting the metabolic and physiological pathological changes of cells. At present, APTw imaging has shown good development prospects in the imaging of various tumors, especially in the application of brain tumor and tumor treatment. This article aims to describe the basic prin-ciples of APTw imaging and the current research status, shortcomings, and prospects of APTw im-aging in tumors.
文章引用：向绪洋, 李孝忠, 林慧婷. 酰胺质子转移加权成像对肿瘤的研究进展[J]. 临床医学进展, 2023, 13(12): 19575-19582. https://doi.org/10.12677/ACM.2023.13122756

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