用于腰椎间盘突出治疗的纳米材料的研究进展
Advances in Nanomaterials for the Treatment of Lumbar Disc Herniation
DOI: 10.12677/ACM.2023.13122761, PDF,    科研立项经费支持
作者: 段佑昌：齐鲁理工学院，山东 济南；董 方：济宁医学院附属医院，重症医学科，山东 济宁
关键词: 腰椎间盘突出；纳米材料；腰椎间盘；纳米纤维素；Lumbar Disc Herniation； Nano Materials； Lumbar Disc； Nanocellulose
摘要: 纳米材料在腰椎间盘突出治疗中具有巨大潜力。它们可以作为支架和模板促进腰椎间盘细胞增殖和分化，调控细胞外基质合成和降解，并实现针对性药物传递。已有研究报道了纳米纤维素、纳米羟基磷灰石、纳米聚合物等材料的应用。然而，纳米材料在安全性和生物相容性、制备和表征技术改进、临床转化和商业化前景等方面仍面临挑战。未来研究应关注纳米材料与腰椎间盘组织的相互作用机制、安全有效的纳米材料开发和联合应用。纳米材料的临床转化和商业化前景将逐渐明确，为患者提供更好的治疗选择。
Abstract: Nanomaterials have great potential in the treatment of lumbar disc herniation. They can serve as scaffolds and templates to promote the proliferation and differentiation of lumbar disc cells, regu-late the synthesis and degradation of extracellular matrix, and achieve targeted drug delivery. There have been studies reporting the application of materials such as nanocellulose, nano hy-droxyapatite, and nano polymers. However, nanomaterials still face challenges in terms of safety and biocompatibility, improved preparation and characterization techniques, clinical conversion, and commercialization prospects. Future research should focus on the interaction mechanism be-tween nanomaterials and lumbar disc tissue, as well as the development and joint application of safe and effective nanomaterials. The clinical transformation and commercialization prospects of nanomaterials will gradually become clear, providing patients with better treatment options.
文章引用：段佑昌, 董方. 用于腰椎间盘突出治疗的纳米材料的研究进展[J]. 临床医学进展, 2023, 13(12): 19612-19621. https://doi.org/10.12677/ACM.2023.13122761

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