鹦鹉热衣原体肺炎1例及文献复习
A Case of Chlamydia psittaci Pneumonia and Literature Review
DOI: 10.12677/MD.2023.134064, PDF,   
作者: 周智明：河北省人民医院老年呼吸内科，河北 石家庄；河北北方学院研究生学院，河北 张家口；平 芬, 瞿道群：河北省人民医院老年呼吸内科，河北 石家庄
关键词: 鹦鹉热衣原体；社区获得性肺炎；宏基因组二代测序；四环素类抗生素；Chlamydia psittaci； Community-Acquired Pneumonia； Metagenomic Next-Generation Sequencing； Tetracycline Antibiotics
摘要: 鹦鹉热衣原体肺炎是社区获得性肺炎的一种，患者一般有禽鸟类接触史，其症状及影像学表现缺乏特异性，主要通过宏基因组二代测序(metagenomic Next-Generation Sequencing, mNGS)技术鉴别，治疗首选四环素类抗生素。文章报道1例给予经验性抗感染治疗效果欠佳的社区获得性肺炎患者，后经mNGS明确是鹦鹉热衣原体感染，给予盐酸米诺环素抗感染治疗后，病情好转出院。文章结合其病历资料及相关文献，综述鹦鹉热衣原体感染的特点及诊疗方法，以期加快临床上对该疾病的诊断和治疗。
Abstract: Chlamydia psittaci pneumonia is a kind of community-acquired pneumonia. Patients generally have a history of contact with birds, and their symptoms and imaging manifestations lack specificity, which can be identified mainly through metagenomic Next-Generation Sequencing (mNGS) tech-nology. Tetracycline antibiotics are the preferred treatment. In this paper, a patient with commu-nity-acquired pneumonia who had poor response to empirical anti-infective therapy was confirmed to be Chlamydia psittaci infection by mNGS. After anti-infective treatment with minocycline hydro-chloride, his condition improved and he was discharged. This article reviews the characteristics, diagnosis and treatment methods of Chlamydia psittaci infection based on its medical records and related literature, so as to accelerate the diagnosis and treatment of this disease in clinical practice.
文章引用：周智明, 平芬, 瞿道群. 鹦鹉热衣原体肺炎1例及文献复习[J]. 医学诊断, 2023, 13(4): 421-425. https://doi.org/10.12677/MD.2023.134064

参考文献

[1] Hogerwerf, L., De Gier, B., Baan, B. and van der Hoek, W. (2017) Chlamydia psittaci (Psittacosis) as a Cause of Communi-ty-Acquired Pneumonia: A Systematic Review and Meta-Analysis. Epidemiology and Infection, 145, 3096-3105. [Google Scholar] [CrossRef] 
[2] Rybarczyk, J., Versteele, C., Lernout, T. and Vanrompay, D. (2020) Human Psittacosis: A Review with Emphasis on Surveillance in Belgium. Acta Clinica Belgica, 75, 42-48. [Google Scholar] [CrossRef] [PubMed]
[3] 沈凌, 等. 鹦鹉热衣原体肺炎48例临床特征分析[J]. 中华结核和呼吸杂志, 2021, 44(10): 886-891.
[4] Lenny, H., Roof, I., de Jong, M.J.K., Dijkstra, F. and van der Hoek, W. (2020) Animal Sources for Zoonotic Transmission of Psittacosis: A Systematic Review. BMC Infectious Diseases, 20, Article No. 192. [Google Scholar] [CrossRef] [PubMed]
[5] Lei, J.H., Xu, Y., Jiang, Y.F., Shi, Z.H. and Guo, T. (2020) Clustering Cases of Chlamydia psittaci Pneumonia in COVID-19 Screening Ward Staff. Clinical Infectious Diseases, 73, e3261-e3265. [Google Scholar] [CrossRef] [PubMed]
[6] Kong, C.Y., Zhu, J., Lu, J.J. and Xu, Z.H. (2021) Clinical Characteristics of Chlamydia psittaci Pneumonia. Chinese Medical Journal, 134, 353-355. [Google Scholar] [CrossRef] 
[7] Lei, G., et al. (2020) The Application of Metagenomic Next-Generation Sequencing in Diagnosing Chlamydia psittaci Pneumonia: A Report of Five Cases. BMC Pulmonary Medicine, 20, Article No. 65. [Google Scholar] [CrossRef] [PubMed]
[8] 张亭亭, 等. 鹦鹉热衣原体肺炎特征的临床研究[J]. 中国临床保健杂志, 2022, 25(5): 703-707.
[9] 庞莉, 等. 鹦鹉热衣原体肺炎10例临床特征分析[J]. 中华医院感染学杂志, 2022, 32(18): 2762-2766.
[10] 方昌全, 等. 鹦鹉热衣原体重症社区获得性肺炎六例分析[J]. 中华急诊医学杂志, 2021, 30(11): 1371-1374.
[11] Balsamo, G., et al. (2017) Compendium of Measures to Control Chlamydia psittaci Infection among Humans (Psit-tacosis) and Pet Birds (Avian Chlamydiosis), 2017. Journal of Avian Medicine and Surgery, 31, 262-282. [Google Scholar] [CrossRef] [PubMed]
[12] 高流芳, 张民伟, 宁耀贵. 重症鹦鹉热衣原体肺炎诊治分析[J]. 中国医药指南, 2022, 20(36): 1-4.
[13] 李济民, 等. 本地6例鹦鹉热肺炎的影像学表现及临床特征[J]. 中国中西医结合影像学杂志, 2023, 21(1): 27-30.
[14] Jin, W., et al. (2023) Clinical Features of Psittacosis in 46 Chinese Patients. Enfermedades infecciosas y microbiologia clinica, 41, 545-548. [Google Scholar] [CrossRef] [PubMed]
[15] Shi, Y.F., et al. (2021) A Case of Chlamydia psittaci Caused Severe Pneumonia and Meningitis Diagnosed by Metagenome Next-Generation Sequencing and Clinical Analysis: A Case Report and Literature Review. BMC Infectious Diseases, 21, Article No. 621. [Google Scholar] [CrossRef] [PubMed]
[16] Nieuwenhuizen, A.A., Dijkstra, F., Notermans, D.W. and van der Hoek, W. (2018) Laboratory Methods for Case Finding in Human Psittacosis Outbreaks: A Systematic Review. BMC Infectious Diseases, 18, Article No. 442. [Google Scholar] [CrossRef] [PubMed]
[17] Lin, P., et al. (2022) Diagnostic Value of Metagenomic Next-Generation Se-quencing of Bronchoalveolar Lavage Fluid for the Diagnosis of Suspected Pneumonia in Immunocompromised Patients. BMC Infec-tious Diseases, 22, Article No. 416. [Google Scholar] [CrossRef] [PubMed]
[18] Chen, Y., et al. (2021) Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Pulmonary Infectious Pathogens from Bronchoalveolar Lavage Samples. Frontiers in Cellular and Infection Microbiology, 11, Article 541092. [Google Scholar] [CrossRef] [PubMed]
[19] 王艳泓, 等. 结合宏基因组二代测序诊断的八例鹦鹉热患者临床分析[J]. 中国呼吸与危重监护杂志, 2021, 20(7): 472-478.
[20] 程旭芳, 等. 某三甲医院9例鹦鹉热衣原体肺炎病例临床特征[J]. 现代疾病预防控制, 2023, 34(8): 578-582.
[21] 庞晴晴, 白梦茹, 尤青海. 肺泡灌洗液联合mNGS在免疫抑制合并肺部感染病原学的应用[J]. 临床肺科杂志, 2023, 28(3): 368-373.
[22] 瞿介明, 曹彬. 中国成人社区获得性肺炎诊断和治疗指南(2016年版) [J].中华结核和呼吸杂志, 2016, 39(4): 253-279.