影响COPD及呼吸衰竭预后的相关因素分析

Analysis of Related Factors Affecting Prognosis of COPD and Respiratory Failure

摘要: 慢性阻塞性肺疾病及呼吸衰竭的患者，其发病率及死亡率还处于较高水平，已成为我国医疗领域的经济负担。近年来，研究发现，炎症反应水平及营养状况与COPD及呼吸衰竭的发生、发展和患者的预后具有一定的相关性。营养风险筛查NRS2002评分及血清白蛋白水平(ALB)等常用于临床营养评估。营养评估结果不佳的患者，其生活质量和病情演变均呈负向趋势，导致发病率、住院时间、死亡率和卫生支出均增加。早期识别并给予足够的营养支持，才能预防或逆转营养不良。本综述中，通过观察外周血炎症及营养指标，间接反应COPD及呼吸衰竭预后及进展情况，将展开描述主要炎症细胞及营养指标与COPD及呼吸衰竭预后的关系，以及主要炎症细胞在COPD及呼吸衰竭气道重塑中的作用，以期为临床干预提供参考价值。

Abstract: The morbidity and mortality of patients with chronic obstructive pulmonary disease and respirato-ry failure are still at a high level, which has become an economic burden in China’s medical field. In recent years, studies have found that the level of inflammatory response and nutritional status are related to the occurrence, development and prognosis of patients with COPD and respiratory failure. Nutritional risk screening NRS2002 score and serum albumin level (ALB) are commonly used in clinical nutritional assessment. Patients with poor nutritional assessments have negative trends in both quality of life and disease evolution, resulting in increased morbidity, length of hospital stay, mortality, and health expenditures. Early recognition and adequate nutritional support can prevent or reverse malnutrition. In this review, the relationship between major inflammatory cells and nu-tritional markers and the prognosis of COPD and respiratory failure will be described by observing the peripheral blood inflammation and nutritional indicators, which indirectly reflect the prognosis and progression of COPD and respiratory failure, and the role of major inflammatory cells in COPD and respiratory failure airway remodeling, in order to provide reference value for clinical interven-tion.