肠道微生物群与心律失常的概述

Overview of the Gut Microbiota and Cardiovascular Disease

摘要: 随着现代生活节奏和人口老龄化的加速推进，不健康生活习惯及饮食方式的日益突出，人们心血管疾病的罹患率逐年升高，患病年龄也越来越提前，其中据不完全统计每年因高血压死于心脑血管意外的人们就多达200万，并且呈逐年上升趋势，据统计，2000年至2010年间，美国住院心血管手术和程序的总数增加了28%，从593.9万增加到758.8万。且成逐年上升趋势，到2018年，超过500,000名的美国人死于心律失常，这表明心律失常对人们健康产生了致命性威胁。心血管疾病后期致残率高，心脏康复花费巨大。给社会及家庭带来巨大经济损失，提示对心血管疾病的早期干预刻不容缓。近年来随着心肠轴的发现，大量实验结果表明，肠道微生物群参与多种心血管疾病的发展，这为心血管疾病的治疗提供了新视野。

Abstract: With the pace of modern life and the aging of population accelerated, unhealthy living habits and diet increasingly prominent, cardiovascular disease rate increased year by year, sick age is more and more early, which according to incomplete statistics died of hypertension cardiovascular acci-dent people as many as 2 million, and with the rising trend year by year, according to statistics, between 2000 and 2010, the total number of hospital cardiovascular surgery and procedures in-creased by 28%, from 5.939 million to 7.588 million. By 2018, more than 500,000 Americans had died from cardiac arrhythmias, suggesting that cardiac arrhythmias pose a fatal threat to people’s health. The disability rate of cardiovascular disease is high, and cardiac rehabilitation is huge. It brings great economic losses to the society and the family, which suggests that the early interven-tion of cardiovascular disease is urgent. With the discovery of the cardiovascular axis in recent years, numerous experimental results show that the gut microbiota is involved in the development of many cardiovascular diseases, which provides a new field for the treatment of cardiovascular diseases.