从肿瘤微环境角度探讨肺癌发病与痰毒的关系
To Explore the Relationship between the Pathogenesis of Lung Cancer and Sputum Toxicity from the Perspective of Tumor Microenvironment
DOI: 10.12677/ACM.2023.13122794, PDF,   
作者: 李云芳:黑龙江中医药大学第一临床医学院,黑龙江 哈尔滨
关键词: 肿瘤微环境肺癌发生痰毒Tumor Microenvironment Lung Carcinoma Incidence Phlegm-Toxin
摘要: 肺癌作为最常见的恶性肿瘤之一,其不断升高的发病率和死亡率严重威胁着人类的身体健康。肿瘤微环境打开了探索肺癌发生发展的新思路,微环境的许多特点与癌症的病因痰毒存在相似性,通过比较两者之间联结的节点,结合痰毒的特点,总结出了解毒化痰,扶正补虚的治疗原则。
Abstract: As one of the most common malignant tumors, lung cancer is a serious threat to human health due to its increasing morbidity and mortality. The tumor microenvironment opens up a new way of thinking about the occurrence and development of lung cancer. Many characteristics of the micro-environment are similar to the sputum toxin of the cause of cancer; the therapeutic principles of detoxification, phlegm elimination, strengthening the body and reinforcing deficiency were sum-marized.
文章引用:李云芳. 从肿瘤微环境角度探讨肺癌发病与痰毒的关系[J]. 临床医学进展, 2023, 13(12): 19843-19846. https://doi.org/10.12677/ACM.2023.13122794

参考文献

[1] Huang, J., Deng, Y., Tin, M.S., et al. (2022) Distribution, Risk Factors, and Temporal Trends for Lung Cancer Incidence and Mortality: A Global Analysis. Chest, 161, 1101-1111. [Google Scholar] [CrossRef] [PubMed]
[2] Xiao, Y. and Yu, D. (2021) Tumor Microenvironment as a Therapeutic Target in Cancer. Pharmacology & Therapeutics, 221, Article ID: 107753. [Google Scholar] [CrossRef] [PubMed]
[3] Cui, Y. and Guo, G. (2016) Immuno-modulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment. Inter-national Journal of Molecular Sciences, 17, 1942. [Google Scholar] [CrossRef] [PubMed]
[4] Francis, A., Venkatesh, G.H., Zaarour, R.F., et al. (2018) Tumor Hy-poxia: A Key Determinant of Microenvironment Hostility and a Major Checkpoint during the Antitumor Response. Crit-ical Reviews in Immunology, 38, 505-524. [Google Scholar] [CrossRef
[5] Marozzi, M., Parnigoni, A., Negri, A., et al. (2021) In-flammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment. International Journal of Molecular Sciences, 22, 8102. [Google Scholar] [CrossRef] [PubMed]
[6] Li, B., Vincent, A., Cates, J., et al. (2009) Low Levels of Tumor Ne-crosis Factor Alpha Increase Tumor Growth by Inducing an Endothelial Phenotype of Monocytes Recruited to the Tumor Site. Cancer Research, 69, 338-348. [Google Scholar] [CrossRef
[7] Xie, Q.H., Zheng, J.Q., Ding, J.Y., et al. (2022) Exo-some-Mediated Immunosuppression in Tumor Microenvironments. Cells, 11, 1946. [Google Scholar] [CrossRef] [PubMed]
[8] Arneth, B. (2019) Tumor Microenvironment. Medicina (Kaunas), 56, 15. [Google Scholar] [CrossRef] [PubMed]
[9] Fang, J., Xiao, L., Joo, K.I., et al. (2016) A Potent Immuno-toxin Targeting Fibroblast Activation Protein for Treatment of Breast Cancer in Mice. International Journal of Cancer, 138, 1013-1023. [Google Scholar] [CrossRef] [PubMed]
[10] 曲玉婷, 康宁, 宋凤丽, 等. 基于伏邪癌毒理论探讨恶性肿瘤的病机、转归和治则[J]. 现代中医临床, 2023, 30(6): 76-79.
[11] Jing, X., Yang, F., Shao, C., et al. (2019) Role of Hypoxia in Cancer Therapy by Regulating the Tumor Microenvironment. Molecular Cancer, 18, 157. [Google Scholar] [CrossRef] [PubMed]
[12] 罗文婧, 郭靖毓, 赵腾飞, 等. 李艺从“毒、虚”辨治肺癌经验[J]. 中医药临床杂志, 2023, 35(9): 1718-1722.
[13] 薛贝, 李富增, 吕思缘, 等. 王成祥教授采用扶正化痰解毒法治疗肺癌经验撷粹[J]. 世界中西医结合杂志, 2022, 17(2): 268-271+298.
[14] 陈滨海, 郑健, 庞德湘. 肺金生方治疗肺癌经验传承体悟[J]. 中华中医药杂志, 2017, 32(1): 150-152.
[15] 刘远财, 周夏成, 杨佳颖, 等. 基于痰毒理论浅析清肺合剂调节肿瘤微环境治疗肺癌的作用[J]. 基层中医药, 2023, 2(10): 74-78.
[16] 王世凤, 刘荣奎. 运用中医疗法从毒邪论治肺癌[J]. 中医临床研究, 2023, 15(23): 103-107.