在青海省锁阳对日光性皮炎发病机制的应用
Application of Cynomorium songaricum on the Pathogenesis of Solar Dermatitis in Qinghai Province
DOI: 10.12677/ACM.2023.13122795, PDF,   
作者: 吴小涵, 王洪瑾:青海大学附属医院烧伤整形科,青海 西宁
关键词: 日光性皮炎锁阳抗氧化Solar Dermatitis Cynomorium songaricum Antioxidant
摘要: 随着天气转暖,日照时间逐渐加长,光照强度也越来越强,日光性皮炎发病率也随之上升。现全球变暖趋势显著,臭氧层破坏,抵御紫外线辐射强度降低,紫外线更容易的照射在地球表面,可引起皮肤光损伤、光老化。我国各地区都有发生,且在日照长、紫外线强的高原地区尤为明显。青海省有高等被子植物近1.2万种,淀粉类植物有蕨麻、锁阳、黄精、玉竹等50余种。针对锁阳提取物的抗氧化等成分运用到日光性皮炎的治疗上,是一个较新的研究方向,在治疗药物上的新突破减少了激素类药物的应用。
Abstract: As the weather gets warmer, the sunshine time gradually lengthens and the light intensity becomes stronger, and the incidence of solar dermatitis also increases. The current trend of global warming is significant, the ozone layer is destroyed, and the intensity of resistance to ultraviolet radiation is reduced. Ultraviolet rays are more easily irradiated on the earth’s surface, which can cause skin photodamage and photoaging. It occurs in all regions of my country, and is especially obvious in plateau areas with long sunshine and strong ultraviolet rays. There are nearly 12,000 species of higher angiosperms in Qinghai Province, and more than 50 species of starchy plants, including ferns, Cynomorium, Polygonatum, Polygonatum, etc. The application of antioxidants and other components of Cynomorium songaricum extract to the treatment of solar dermatitis is a relatively new research direction. New breakthroughs in therapeutic drugs have reduced the use of hormone drugs.
文章引用:吴小涵, 王洪瑾. 在青海省锁阳对日光性皮炎发病机制的应用[J]. 临床医学进展, 2023, 13(12): 19847-19850. https://doi.org/10.12677/ACM.2023.13122795

参考文献

[1] 中华医学会, 中华医学会杂志社, 中华医学会皮肤性病学分会, 中华医学会全科医学分会, 中华医学会《中华全科医师杂志》编辑委员会, 皮肤病与性病基层诊疗指南编写专家组. 日晒伤基层诊疗指南(2023年) [J]. 中华全科医师杂志, 2023, 22(4): 348-352. [Google Scholar] [CrossRef
[2] 侯巍, 许庆芳, 刘晨, 等. 组织蛋白酶B在急性光损伤皮肤成纤维细胞中的表达及意义[J]. 中华皮肤科杂志, 2014, 47(11): 776-779. [Google Scholar] [CrossRef
[3] 成娟. 春末夏初警惕日光性皮炎[J]. 开卷有益(求医问药), 2022(4): 6.
[4] 汉瑞娟, 李娟, 朱鑫华, 陆皓. 高原日光性皮炎防护研究进展[J]. 解放军护理杂志, 2016, 33(17): 45-46.
[5] Dubakiene, R. and Kupriene, M. (2006) Scientific Problems of Photosensitivity. Medicina (Kaunas), 42, 619-624.
[6] Maniam, G., Light, K.M. and Wilson, J. (2021) Margarita Burn: Recognition and Treatment of Phytophotodermatitis. Journal of the American Board of Family Medicine, 34, 398-401. [Google Scholar] [CrossRef] [PubMed]
[7] Xiao, J., Lu, H., Ma, T., Ni, X., Chang, T., Liu, M., et al. (2022) Worenine Prevents Solar Ultraviolet-Induced Sunburn by Inhibiting JNK2. Frontiers in Pharmacology, 13, Arti-cle ID: 881042. [Google Scholar] [CrossRef] [PubMed]
[8] Fan, X., Duan, Q., Ke, C., Zhang, G., Xiao, J., Wu, D., et al. (2016) Cefradine Blocks Solar-Ultraviolet Induced Skin Inflammation through Direct Inhibition of T-LAK Cell-Originated Protein Kinase. Oncotarget, 7, 24633-24645. [Google Scholar] [CrossRef] [PubMed]
[9] Fang, Y., Chen, L., Wang, X., Li, X., Xiong, W., Zhang, X., et al. (2022) UVB Irradiation Differential Regulate miRNAs Expression in Skin Photoaging. Anais Brasileiros de Dermatolo-gia, 97, 458-466. [Google Scholar] [CrossRef] [PubMed]
[10] 李会绒. 日光性皮炎的预防与治疗[J]. 现代中西医结合杂志, 2009, 18(12): 1405-1407. [Google Scholar] [CrossRef
[11] Passeron, T., Zouboulis, C.C., Tan, J., Andersen, M.L., Katta, R., Lyu, X., Aguilar, L., et al. (2021) Adult Skin Acute Stress Responses to Short-Term Environmental and Inter-nal Aggression from Exposome Factors. Journal of the European Academy of Dermatology and Venereology, 35, 1963-1975. [Google Scholar] [CrossRef] [PubMed]
[12] Young, A.R. (2006) Acute Effects of UVR on Human Eyes and Skin. Progress in Biophysics and Molecular Biology, 92, 80-85. [Google Scholar] [CrossRef] [PubMed]
[13] Segars, K., McCarver, V. and Miller, R.A. (2021) Derma-tologic Applications of Polypodium leucotomos: A Literature Review. The Journal of Clinical and Aesthetic Dermatology, 14, 50-60.
[14] Hao, D., Wen, X., Liu, L., Wang, L., Zhou, X., Li, Y., Zeng, X., He, G. and Jiang, X. (2019) Sanshool Improves UVB-Induced Skin Photodamage by Targeting JAK2/STAT3-Dependent Autophagy. Cell Death & Disease, 10, Article No. 19. [Google Scholar] [CrossRef] [PubMed]
[15] 毛小文, 顾志荣, 吕鑫, 祁梅, 葛斌. 锁阳的资源化学、药理作用及开发利用研究进展[J]. 中国野生植物资源, 2022, 41(4): 50-54. [Google Scholar] [CrossRef
[16] Wang, J., Su, H., Han, H., Wang, W., Li, M., Zhou, Y., Li, Y. and Li, M. (2021) Transcriptomics Reveals Host- Dependent Differences of Polysaccharides Biosynthesis in Cynomorium songaricum. Molecules, 27, Article No. 44. [Google Scholar] [CrossRef] [PubMed]
[17] Zucca, P., Bellot, S. and Rescigno, A. (2019) The Modern Use of an Ancient Plant: Exploring the Antioxidant and Nutraceutical Potential of the Maltese Mushroom (Cynomorium coc-cineum L.). Antioxidants (Basel), 8, Article No. 289. [Google Scholar] [CrossRef] [PubMed]