肠道菌群–胆汁酸通路与2型糖尿病的关系
Correlation between Intestinal Flora-Bile Acid Related Pathway and Type 2 Diabetes
摘要: 肠道菌群通过多种途径参与2型糖尿病(T2DM)的发生发展过程，导致胰岛素抵抗(IR)、胰岛β细胞功能损伤和糖原合成及代谢紊乱，不断推动糖脂代谢并发症的发展。胆汁酸(BAs)作为肠道菌群代谢产物，与其内源性受体结合，包括法尼醇X核受体(FXR)和G蛋白偶联胆汁酸受体1 (TGR5)，对T2DM产生影响。本文对肠道菌群–胆汁酸轴与T2DM关系的内在机制及相互影响进行综述。
Abstract: Intestinal flora participates in the occurrence and development of type 2 diabetes (T2DM) through various ways, leading to insulin resistance (IR) and pancreatic islets β damage to cellular function and disruption of glycogen synthesis and metabolism, continuing to drive the development of com-plications in glycolipid metabolism. Bile acids (BAs), as metabolites of Intestinal flora, bind to their endogenous receptors, including farnesol X Nuclear receptor (FXR) and G protein coupled Bile acid receptor 1 (TGR5), which affect T2DM. This article reviews the internal mechanism and interaction between Intestinal flora-Bile acid axis and T2DM.
文章引用：岳晓岩, 张瑞霞. 肠道菌群–胆汁酸通路与2型糖尿病的关系[J]. 临床医学进展, 2023, 13(12): 19851-19856. https://doi.org/10.12677/ACM.2023.13122796

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