评估炎症性肠病严重程度及预后的最新进展
The Latest Progress in Evaluating the Severity and Prognosis of Inflammatory Bowel Disease
DOI: 10.12677/ACM.2023.13122813, PDF,   
作者: 唐努尔·玉山江:新疆医科大学研究生院,新疆 乌鲁木齐;黄晓玲*:新疆维吾尔自治区人民医院消化内科,新疆 乌鲁木齐
关键词: 溃疡性结肠炎生物学标志物疾病严重程度Ulcerative Colitis Biological Marker Disease Severity
摘要: 溃疡性结肠炎(Ulcerative colitis, UC)是一种病因不明的慢性非特异性肠道炎症性疾病。结肠镜检查是评估UC严重程度的金标准,然而作为费用高和需具备相应的医疗条件的有创检查,不是最方便的评估工具。因此方便、快速、费用低的生物学标志对判断UC严重程度意义重大。本文对评估UC严重程度有意义的因素进行综述。
Abstract: Ulcerative colitis (UC) is a chronic, nonspecific inflammatory bowel disease of unknown etiology. Co-lonoscopy is the gold standard for assessing the severity of UC, but as an invasive examination with high cost and medical conditions, it is not the most convenient assessment tool. Therefore, conven-ient, rapid and low-cost biological markers are of great significance in judging the severity of UC. This article reviews the biological markers that are significant in assessing the severity of UC.
文章引用:唐努尔·玉山江, 黄晓玲. 评估炎症性肠病严重程度及预后的最新进展[J]. 临床医学进展, 2023, 13(12): 19973-19979. https://doi.org/10.12677/ACM.2023.13122813

参考文献

[1] Kornbluth, A. and Sachar, D.B. (2010) Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroen-terology, Practice Parameters Committee. The American Journal of Gastroenterology, 105, 501-523. [Google Scholar] [CrossRef] [PubMed]
[2] Cosnes, J., Gower-Rousseau, C., Seksik, P. and Cortot, A. (2011) Epi-demiology and Natural History of Inflammatory Bowel Diseases. Gastroenterology, 140, 1785-1794. [Google Scholar] [CrossRef] [PubMed]
[3] Prideaux, L., Kamm, M.A., De Cruz, P.P., Chan, F.K. and Ng, S.C. (2012) Inflammatory Bowel Disease in Asia: A Systematic Review. Journal of Gastroenterology and Hepatology, 27, 1266-1280. [Google Scholar] [CrossRef] [PubMed]
[4] Stowe, S.P., Redmond, S.R., Stormont, J.M., Shah, A.N., Chessin, L.N., Segal, H.L. and Chey, W.Y. (1990) An Epidemiologic Study of Inflammatory Bowel Disease in Roches-ter, New York. Hospital Incidence. Gastroenterology, 98, 104-110. [Google Scholar] [CrossRef
[5] Loftus, C.G., Loftus, E.V., Harmsen, W.S., Zinsmeister, A.R., Tremaine, W.J., Melton, L.J. and Sandborn, W.J. (2007) Update on the Incidence and Prevalence of Crohn’s Disease and Ulcerative Colitis in Olmsted County, Minnesota, 1940-2000. Inflammatory Bowel Diseases, 13, 254-261. [Google Scholar] [CrossRef] [PubMed]
[6] Souza, M.H., Troncon, L.E., Rodrigues, C.M., Viana, C.F., Onofre, P.H., Monteiro, R.A., Passos, A.D., Martinelli, A.L. and Meneghelli, U.G. (2002) Trends in the Occurrence (1980-1999) and Clinical Features of Crohn’s Disease and Ulcerative Colitis in a University Hospital in Southeastern Brazil. Arquivos de Gastroenterologia, 39, 98-105.
[7] Peeters, M., Cortot, A., Vermeire, S. and Colombel, J.F. (2000) Familial and Spo-radic Inflammatory Bowel Disease: Different Entities? Inflammatory Bowel Diseases, 6, 314-320. [Google Scholar] [CrossRef] [PubMed]
[8] Halme, L., Turunen, U., Heliö, T., Paavola, P., Walle, T., Miettinen, A., Järvinen, H., Kontula, K. and Färkkilä, M. (2002) Familial and Sporadic Inflammatory Bowel Disease: Comparison of Clinical Features and Serological Markers in a Genetically Homogeneous Population. Scandinavian Journal of Gas-troenterology, 37, 692-698. [Google Scholar] [CrossRef] [PubMed]
[9] Kuwahara, E., Asakura, K., Nishiwaki, Y., Inoue, N., Watanabe, M., Hibi, T. and Takebayashi, T. (2012) Effects of Family History on Inflammatory Bowel Disease Characteristics in Japa-nese Patients. Journal of Gastroenterology, 47, 961-968. [Google Scholar] [CrossRef] [PubMed]
[10] Bottini, N., Gloria-Bottini, F., Lucarini, N., Ronchetti, P.G. and Fontana, L. (2000) Inflammatory Bowel Disease: Are There Gender Differences in the Genetics of Signal Transduction? A Preliminary Study of Cytosolic Low Molecular Weight Protein Tyrosine Phosphatase. Disease Markers, 16, 163-166. [Google Scholar] [CrossRef] [PubMed]
[11] Teruel, M., Martin, J.E., Gómez-García, M., Cardeña, C., Rodrigo, L., Nieto, A., Alcain, G., Cueto, I., López-Nevot, M.A. and Martin, J. (2012) Lack of Association of ACP1 Gene with Inflammatory Bowel Disease: A Case-Control Study. Tissue Antigens, 80, 61-64. [Google Scholar] [CrossRef] [PubMed]
[12] Barreiro-de Acosta, M., Magro, F., Carpio, D., Lago, P., Echarri, A., Cotter, J., Pereira, S., Gonçalves, R., Lorenzo, A., Carvalho, L., Castro, J., Barros, L., Dias, J.A., Rodrigues, S., Portela, F., Dias, C. and da Costa-Pereira, A. (2010) Ulcerative Colitis in Northern Portugal and Galicia in Spain. Inflammatory Bowel Diseases, 16, 1227-1238. [Google Scholar] [CrossRef] [PubMed]
[13] Betteridge, J.D., Armbruster, S.P., Maydonovitch, C. and Veerappan, G.R. (2013) Inflammatory Bowel Disease Prevalence by Age, Gender, Race, and Geographic Location in the U.S. Military Health Care Population. Inflammatory Bowel Diseases, 19, 1421-1427. [Google Scholar] [CrossRef
[14] Wallace, K.L., Zheng, L.B., Kanazawa, Y. and Shih, D.Q. (2014) Immunopathology of Inflammatory Bowel Disease. World Journal of Gastroenterology, 20, 6-21. [Google Scholar] [CrossRef] [PubMed]
[15] Koloski, N.A., Bret, L. and Radford-Smith, G. (2008) Hygiene Hypothe-sis in Inflammatory Bowel Disease: A Critical Review of the Literature. World Journal of Gastroenterology, 14, 165-173. [Google Scholar] [CrossRef] [PubMed]
[16] Calkins, B.M. (1989) A Meta-Analysis of the Role of Smoking in In-flammatory Bowel Disease. Digestive Diseases and Sciences, 34, 1841-1854. [Google Scholar] [CrossRef
[17] Odes, H.S., Fich, A., Reif, S., Halak, A., Lavy, A., Keter, D., Eliakim, R., Paz, J., Broide, E., Niv, Y., Ron, Y., Villa, Y., Arber, N. and Gilat, T. (2001) Effects of Current Cigarette Smoking on Clinical Course of Crohn’s Disease and Ulcerative Colitis. Digestive Diseases and Sciences, 46, 1717-1721. [Google Scholar] [CrossRef
[18] Aldhous, M.C., Drummond, H.E., Anderson, N., Baneshi, M.R., Smith, L.A., Arnott, I.D. and Satsangi, J. (2007) Smoking Habit and Load Influence Age at Diagnosis and Disease Ex-tent in Ulcerative Colitis. The American Journal of Gastroenterology, 102, 589-597. [Google Scholar] [CrossRef] [PubMed]
[19] DuPont, A.W. and DuPont, H.L. (2011) The Intestinal Mi-crobiota and Chronic Disorders of the Gut. Nature Reviews Gastroenterology & Hepatology, 8, 523-531. [Google Scholar] [CrossRef] [PubMed]
[20] Satsangi, J., Silverberg, M.S., Vermeire, S. and Colombel, J.F. (2006) The Montreal Classification of Inflammatory Bowel Disease: Controversies, Consensus, and Implications. Gut, 55, 749-753. [Google Scholar] [CrossRef] [PubMed]
[21] Riegler, G., Tartaglione, M.T., Carratú, R., D’Incá, R., Valpiani, D., Russo, M.I., Papi, C., Fiorentini, M.T., Ingrosso, M., Andreoli, A. and Vecchi, M. (2000) Age-Related Clinical Severity at Diagnosis in 1705 Patients with Ulcerative Colitis: A Study by GISC (Italian Colon-Rectum Study Group). Digestive Diseases and Sciences, 45, 462-465. [Google Scholar] [CrossRef
[22] Solberg, I.C., Lygren, I., Jahnsen, J., Aadland, E., Høie, O., Cvancarova, M., et al. (2009) Clinical Course during the First 10 Years of Ulcerative Colitis: Results from a Popula-tion-Based Inception Cohort (IBSEN Study). Scandinavian Journal of Gastroenterology, 44, 431-440. [Google Scholar] [CrossRef] [PubMed]
[23] Kalkan, I.H., Dağli, U., Oztaş, E., Tunç, B. and Ulker, A. (2013) Comparison of Demographic and Clinical Characteristics of Patients with Early vs. Adult vs. Late Onset Ulcerative Coli-tis. European Journal of Internal Medicine, 24, 273-277. [Google Scholar] [CrossRef] [PubMed]
[24] Charpentier, C., Salleron, J., Savoye, G., Fumery, M., Merle, V., Laberenne, J.E., et al. (2014) Natural History of Elderly-Onset Inflammatory Bowel Disease: A Population-Based Cohort Study. Gut, 63, 423-432. [Google Scholar] [CrossRef] [PubMed]
[25] Tremaine, W.J., Timmons, L.J., Loftus, E.V., Pardi, D.S., Sand-born, W.J., Harmsen, W.S., et al. (2007) Age at Onset of Inflammatory Bowel Disease and the Risk of Surgery for Nonneoplastic Bowel Disease. Alimentary Pharmacology & Therapeutics, 25, 1435-1441. [Google Scholar] [CrossRef] [PubMed]
[26] Lee, J.H., Cheon, J.H., Moon, C.M., Park, J.J., Hong, S.P., Kim, T.I. and Kim, W.H. (2010) Do Patients with Ulcerative Colitis Diagnosed at a Young Age Have More Severe Dis-ease Activity than Patients Diagnosed When Older? Digestion, 81, 237-243. [Google Scholar] [CrossRef] [PubMed]
[27] Jahnsen, J., Falch, J.A., Mowinckel, P. and Aadland, E. (2003) Body Composition in Patients with Inflammatory Bowel Disease: A Population-Based Study. The American Journal of Gas-troenterology, 98, 1556-1562. [Google Scholar] [CrossRef] [PubMed]
[28] Ng, S.C., Tang, W., Ching, J.Y., Wong, M., Chow, C.M., Hui, A.J., et al. (2013) Incidence and Phenotype of Inflammatory Bowel Disease Based on Results from the Asia-Pacific Crohn’s and Colitis Epidemiology Study. Gastroenterology, 145, 158-165.e2. [Google Scholar] [CrossRef] [PubMed]
[29] Alkim, C., Alkim, H., Dağli, U., Parlak, E., Ulker, A. and Sahın, B. (2011) Extension of Ulcerative Colitis. Turkish Journal of Gastroenterology, 22, 382-387. [Google Scholar] [CrossRef] [PubMed]
[30] Kiss, L.S. and Lakatos, P.L. (2011) Natural History of Ulcerative Colitis: Current Knowledge. Current Drug Targets, 12, 1390-1395. [Google Scholar] [CrossRef] [PubMed]
[31] Lennard-Jones, J.E., Ritchie, J.K., Hilder, W. and Spicer, C.C. (1975) Assessment of Severity in Colitis: A Preliminary Study. Gut, 16, 579-584. [Google Scholar] [CrossRef] [PubMed]
[32] Lasson, A., Simrén, M., Stotzer, P.O., Isaksson, S., Ohman, L. and Strid, H. (2013) Fecal Calprotectin Levels Predict the Clinical Course in Patients with New Onset of Ulcerative Colitis. In-flammatory Bowel Diseases, 19, 576-581. [Google Scholar] [CrossRef
[33] Lakatos, L., Pandur, T., David, G., Balogh, Z., Kuronya, P., Tollas, A. and Lakatos, P.L. (2003) Association of Extraintestinal Manifestations of Inflammatory Bowel Disease in a Province of Western Hungary with Disease Phenotype: Results of a 25-Year Follow-Up Study. World Journal of Gas-troenterology, 9, 2300-2307. [Google Scholar] [CrossRef] [PubMed]
[34] Loftus, E.V., Harewood, G.C., Loftus, C.G., Tremaine, W.J., Harm-sen, W.S., Zinsmeister, A.R., Jewell, D.A. and Sandborn, W.J. (2005) PSC-IBD: A Unique Form of Inflammatory Bowel Disease Associated with Primary Sclerosing Cholangitis. Gut, 54, 91-96. [Google Scholar] [CrossRef] [PubMed]
[35] Broomé, U. and Bergquist, A. (2006) Primary Sclerosing Cholangitis, Inflammatory Bowel Disease, and Colon Cancer. Seminars in Liver Disease, 26, 31-41. [Google Scholar] [CrossRef] [PubMed]
[36] Sokol, H., Cosnes, J., Chazouilleres, O., Beaugerie, L., Tiret, E., Pou-pon, R. and Seksik, P. (2008) Disease Activity and Cancer Risk in Inflammatory Bowel Disease Associated with Prima-ry Sclerosing Cholangitis. World Journal of Gastroenterology, 14, 3497-3503. [Google Scholar] [CrossRef] [PubMed]
[37] Soetikno, R.M., Lin, O.S., Heidenreich, P.A., Young, H.S. and Black-stone, M.O. (2002) Increased Risk of Colorectal Neoplasia in Patients with Primary Sclerosing Cholangitis and Ulcera-tive Colitis: A Meta-Analysis. Gastrointestinal Endoscopy, 56, 48-54. [Google Scholar] [CrossRef] [PubMed]
[38] Kornfeld, D., Ekbom, A. and Ihre, T. (1997) Is There an Excess Risk for Colorectal Cancer in Patients with Ulcerative Colitis and Concomitant Primary Sclerosing Cholangitis? A Popu-lation Based Study. Gut, 41, 522-525. [Google Scholar] [CrossRef] [PubMed]
[39] Gerçeker, E. and Cerrah, S. (2023) Platelet, Mean Platelet Volume and Platelet Distribution Width Levels Might Be a Promising Marker for the Prediction of Disease Severity, Mucosal Healing and Steroid Dependence in Patients with Ulcerative Colitis. Cureus, 15, e33286. [Google Scholar] [CrossRef] [PubMed]
[40] 吴银亚, 郑扬, 陈旭峰. CRP/ALB、LMR对溃疡性结肠炎内镜下病情严重程度的评估价值[J]. 中南医学科学杂志, 2023, 51(4): 592-594. [Google Scholar] [CrossRef
[41] 李慧敏, 王莲子, 王中新, 等. 血清PAR水平与溃疡性结肠炎活动期患者严重程度的相关性分析[J]. 中国处方药, 2023, 21(8): 165-168.
[42] Li, A., Wang, Z., Lv, Q. and Ling, Y. (2022) Prognostic Utility of Platelet-to-Albumin Ratio among Critically Ill Patients with Colorectal Cancer: A Propensity Score Matching Study. Journal of Oncology, 2022, Article ID: 6107997. [Google Scholar] [CrossRef] [PubMed]
[43] 郑淑贤, 孟品, 闫静, 等. 全身免疫炎症指数评估溃疡性结肠炎严重程度的价值[J]. 青岛大学学报(医学版), 2023, 59(2): 183-188.
[44] Liu, Y., Liu, L., Qu, Z., Yu, L.L. and Sun, Y. (2023) Supramolecular Assembly of Benzophenone Alanine and Copper Presents High Laccase-Like Activity for the Degradation of Phenolic Pollutants. Journal of Hazardous Materials, 443, Article ID: 130198. [Google Scholar] [CrossRef] [PubMed]