脂多糖在心房颤动中的研究进展
Research Progress of Lipopolysaccharides in Atrial Fibrillation
DOI: 10.12677/ACM.2023.13122822, PDF,   
作者: 陈先慧:青海大学研究生院,青海 西宁
关键词: 肠道微生物群心房颤动脂多糖Gut Microbiota Atrial Fibrillation Lipopolysaccharides
摘要: 最近,很多学者提出肠–心轴假说,并提出心房颤动(atrial fibrillation, AF)中功能失调的肠道微生物群及其代谢物与心脏的相互作用。其中肠道菌群代谢物之一——脂多糖(lipopolysaccharide, LPS)通过其代谢途径直接或间接进促进心脏重塑来增加房颤易感性,促进房颤发生。此外,脂多糖在房颤的防治及预后方面也发挥了一定作用。本综述将从脂多糖促进房颤的发生、发展及其在预后与防治方面的影响展开叙述。
Abstract: Recently, many scholars have proposed the gut cardiac axis hypothesis and proposed the interac-tion between the dysfunctional gut microbiota and its metabolites in atrial fibrillation (AF) and the heart. One of the metabolites of the gut microbiota, lipopolysaccharide (LPS), directly or indirectly promotes heart remodeling through its metabolic pathway to increase susceptibility to atrial fibril-lation and promote its occurrence. In addition, lipopolysaccharides also play a certain role in the prevention, treatment, and prognosis of atrial fibrillation. This review will describe the role of lipo-polysaccharides in promoting the occurrence and development of atrial fibrillation, as well as their impact on prognosis and prevention and treatment.
文章引用:陈先慧. 脂多糖在心房颤动中的研究进展[J]. 临床医学进展, 2023, 13(12): 20037-20041. https://doi.org/10.12677/ACM.2023.13122822

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