TCT、HPV检查在宫颈病变诊断中的应用价值

Application value of TCT and HPV in the Diagnosis of Cervical Lesions

摘要: 目的：探讨临床宫颈病变诊断中采用液基薄层细胞学检查(TCT)及人乳头瘤病毒(HPV)检查的临床应用价值。方法：选择2022年9月至2023年9月在内蒙古自治区人民医院妇科门诊就诊并诊断为宫颈病变的患者99例，所有患者均在阴道镜下取宫颈活组织检查，病理结果回报为宫颈病变，比较TCT或HPV单独检查与二者联合检查诊断宫颈病变的符合率。结果：99例诊断为宫颈病变的患者中，TCT和HPV联合检查对宫颈病变的诊断比单独TCT或单独HPV检查其符合率更高，差异有统计学意义(P < 0.005)。单独HPV检查检出宫颈病变的概率与单独TCT检查相比，其符合率占明显优势，差异有统计学意义(P < 0.005)。对于宫颈高级别及以上级别的阳性病变结果，TCT阳性检出率为20.7%，HPV阳性检出率为31.9%，TCT + HPV阳性检出率为37.1%。由此可见，TCT + HPV联合检测在宫颈高级别及以上级别病变的阳性检出率比TCT或HPV单独检测更有优势，且差异有统计学意义(P < 0.05)。结论：在宫颈病变患者的诊断过程中，应用TCT与HPV联合检查的方式诊断价值更优，可显著提高诊断率，实现宫颈病变的早诊早治。

Abstract: Objective: To investigate the clinical application value of liquid based thin layer cytology (TCT) and human papillomavirus (HPV) in the diagnosis of cervical lesions. Method: A total of 99 patients di-agnosed with cervical lesions were selected from the gynecological outpatient department of Inner Mongolia Autonomous Region People’s Hospital from September 2022 to September 2023. Cervical biopsies were taken under colposcopy for all patients, and the pathological results were reported as cervical lesions. The coincidence rate of TCT or HPV alone and the combined examination were compared for the diagnosis of cervical lesions. Result: Among 99 patients diagnosed with cervical lesions, the coincidence rate of TCT and HPV combined examination for cervical lesions was higher than that of TCT or HPV alone, and the difference was statistically significant (P < 0.005). The proba-bility of cervical lesions detected by HPV alone was significantly higher than that by TCT alone, and the difference was statistically significant (P < 0.005). For positive cervical lesions of high grade and above, the TCT positive detection rate was 20.7%, the HPV positive detection rate was 31.9%, and the TCT + HPV positive detection rate was 37.1%. In conclusion, the positive detection rate of TCT + HPV combined detection in high-grade and above cervical lesions was more advantageous than that of TCT or HPV alone detection, and the difference was statistically significant (P < 0.05). Conclusion: In the diagnosis process of patients with cervical lesions, the combined examination of TCT and HPV has better diagnostic value, which can significantly improve the diagnosis rate and achieve early diagnosis and treatment of cervical lesions.