基于液质联用技术探讨野艾蒿(蒙药名童格勒格-1)降脂抗炎作用
Study on Lipid-Lowering and Anti-Inflammatory Effects of Wild Mugwort (Mongolian Medicine TGLG-1) Based on LC-MS
DOI: 10.12677/ACM.2023.13122824, PDF,    科研立项经费支持
作者: 常家乐, 孔祥宇：内蒙古医科大学，研究生学院，内蒙古 呼和浩特；贾燕飞*, 张葆鑫*, 郝 廷：内蒙古医科大学第二附属院，创伤外科中心，内蒙古 呼和浩特；阿日奔吉日嘎拉, 李斯琴, 王 兴：巴彦淖尔市医院，脊柱外科，内蒙古 巴彦淖尔
关键词: 野艾蒿；童格勒格(TGLG-1)；液质联用技术；抗炎；高脂血症；酒精性骨质疏松症；Wild Mugwort； TGLG-1； LC-MS； Anti-Inflammation； Hyperlipidemia； Alcoholic Osteoporosis
摘要: 蒙药童格勒格(TGLG-1)即野艾蒿是蒙古族人民降脂减肥的经典名方，是蒙医药治疗高脂血症的智慧结晶。作为一种单味蒙药制剂，TGLG-1在临床应用上表现出减肥降脂、抗炎、降血糖、利胆和对抗肾上腺素和组胺对心血管系统引起的收缩等作用。本文基于液质联用技术对TGLG-1药材进行了分析，通过查找文献和结合课题组目前研究，总结了蒙药童格勒格(TGLG-1)主要化学成分及其降脂抗炎的药理学价值，并针对其在治疗酒精性骨质疏松症(AOP)的潜在药理学价值，做出展望。
Abstract: Mongolian medicine TGLG-1 is a classic famous prescription for Mongolian people to reduce lipid and lose weight, and is the intellectual crystal of Mongolian medicine in the treatment of hyper-lipidemia. As a single Mongolian preparation, TGLG-1 has been shown to lose weight and reduce li-pid, reduce blood glucose, and cholagogue and counteract the contraction caused by epinephrine and histamine on the cardiovascular system in clinical application. In this paper, the experimental research and clinical application of Mongolian medicine Tonggleger (TGLG-1) in lipid-lowering and weight-loss are summarized by searching the literature, and its potential pharmacological value in the treatment of alcoholic osteoporosis (AOP) is prospected.
文章引用：常家乐, 贾燕飞, 张葆鑫, 孔祥宇, 阿日奔吉日嘎拉, 郝廷, 李斯琴, 王兴. 基于液质联用技术探讨野艾蒿(蒙药名童格勒格-1)降脂抗炎作用[J]. 临床医学进展, 2023, 13(12): 20048-20061. https://doi.org/10.12677/ACM.2023.13122824

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