儿童缺铁性贫血与维生素D水平相关性研究进展

Progress in the Correlation between Iron Deficiency Anemia and Vitamin D Levels in Children

摘要: 铁和维生素D的缺乏被认为是全球两个主要的公共卫生问题。缺铁性贫血(IDA)是因体内铁缺乏致使血红蛋白合成减少而引起的贫血，缺铁性贫血是儿童常见的慢性疾病，不仅会导致儿童身体发育不良、生长缓慢，还会严重影响儿童智力发育。铁是人体必需的微量元素，对维持人体内血红蛋白、肌红蛋白和代谢相关酶的活性起重要作用，可参与人体的各种生理活动。铁调素是维持机体铁稳态的核心调节因子，可以降低机体血清铁水平，是最重要的铁代谢负性调控因子，近年的研究表明，铁调素可作为IDA早期诊断及疗效评估的指标之一。维生素D缺乏也是婴幼儿时期常见的微量营养素缺乏症，维生素D的代谢似乎依赖于铁，铁的缺乏可能会干扰维生素D的激活。该文就目前关于儿童缺铁性贫血与维生素D水平相关性的研究进展进行介绍。

Abstract: Deficiencies in both vitamin D and iron are recognized as two major public health concerns around the globe. Iron deficiency anemia is a common chronic disease in children, which not only leads to poor body development and slow growth of children but also seriously affects their intellectual de-velopment. Iron, an essential trace element in human body, plays an important role in maintaining the activities of hemoglobin, myoglobin, and metabolic-related enzymes in human body and can participate in various physiological activities of human body. Patients with iron deficiency are often accompanied by oxygen transport disorders, resulting in metabolic disorders and eventually ane-mia. Hepcidin is the core regulator of maintaining iron homeostasis, which reduces serum iron lev-els and is the most important negative regulator of iron metabolism. Recent studies have shown that hepcidin can be used as one of the indicators for the early diagnosis and efficacy evaluation of IDA. Vitamin D deficiency is also a common micronutrient deficiency in infants and young children. Vitamin D metabolism is dependent on iron and its deficiency might disturb vitamin D activation. This paper introduces the current research progress on the correlation between iron deficiency anemia and vitamin D levels in children.