三级淋巴结构与胃癌研究进展

Tertiary Lymphoid Structures and Gastric Cancer Research Progress

摘要: 目的：总结三级淋巴结构在胃癌中抗肿瘤的作用机制，及三级淋巴结构作为预测胃癌免疫治疗疗效及预后的生物标志物的临床研究进展，为今后临床研究提供参考和思路。方法：以“胃癌、三级淋巴结构、免疫治疗、肿瘤”为中文关键词，以“gastric cancer、tertiary lymphoid structure、immunological therapy、tumor”为英文关键词，系统检索中国知网和PubMed数据库建库至2023-06-31的相关文献。文献纳入标准：1) TLS在胃癌预后及治疗中的研究进展；2) TLS与肿瘤之间的研究进展。排除标准：数据陈旧文献、可信度较低的文献。最终纳入64篇文献。结果：TLS已被大部分研究证实可以作为预测胃癌免疫治疗疗效及预后的生物标志物，肿瘤外TLS对于肿瘤预后产生积极效果也有待进一步研究。结论：TLS可以通过肿瘤微环境发挥其可能抑癌或预测预后的作用，具有潜在的肿瘤临床治疗价值，但其作用于肿瘤的复杂机制仍需进一步探索。

Abstract: Objective: To summarize the anti-tumor mechanism of tertiary lymphoid structures in gastric can-cer and the progress of clinical research on tertiary lymphoid structures as biomarkers for predict-ing the efficacy and prognosis of immunotherapy in gastric cancer, so as to provide references and ideas for future clinical research. Methods: Taking “胃癌, 三级淋巴结构, 免疫治疗, 肿瘤” as Chi-nese keywords and “gastric cancer, tertiary lymphatic structure, immunological therapy, tumor” as English keywords, the related literatures built up to June 31, 2023 by China National Knowledge Infrastructure (CNKI) and PubMed database were systematically searched. Inclusion Criteria: 1) The research progress of TLS in the prognosis and treatment of gastric cancer; 2) The research pro-gress between TLS and tumor. Exclusion Criteria: Literature with obsolete data, literature with low credibility. Sixty-four literatures were finally included. Results: TLS has been confirmed by most studies as a biomarker for predicting the efficacy and prognosis of immunotherapy in gastric can-cer, and the positive effect of off-tumor TLS on tumor prognosis needs to be further investigated. Conclusions: TLS can play the possible role of cancer inhibition or prognosis prediction through the tumor microenvironment, which has potential clinical therapeutic value in tumor treatment, but the complex mechanism of its action on tumor still needs to be further explored.