鸢尾素在肥胖及相关代谢性疾病中的研究进展
Research Progress of Irisin in Obesity and Related Metabolic Diseases
DOI: 10.12677/ACM.2023.13122830, PDF,    科研立项经费支持
作者: 张怡宁, 尹 晓*:山东大学齐鲁医学院,山东 济南;济南市中心医院代谢性疾病中心,山东 济南
关键词: 鸢尾素肥胖症2型糖尿病动脉粥样硬化性心血管疾病非酒精性脂肪性肝病骨质疏松症Irisin Obesity Type 2 Diabetes Atherosclerotic Cardiovascular Disease Non-Alcoholic Fatty Liver Disease Osteoporosis
摘要: 目前肥胖及相关代谢性疾病在全球呈持续流行的态势,已成为严重的公共卫生问题。鸢尾素是运动期间由骨骼肌分泌产生的肌源性细胞因子,通过多种信号通路改善肥胖及代谢异常。本文对鸢尾素与肥胖及相关代谢性疾病的关系进行综述,主要包括2型糖尿病、动脉粥样硬化性心血管疾病、非酒精性脂肪性肝病和骨质疏松症,旨在阐明鸢尾素在代谢靶器官中的调控机制,为肥胖及相关代谢性疾病探索新的治疗途径。
Abstract: Obesity and related metabolic diseases are continuously epidemic worldwide and have become a serious public health problem. Irisin, a myokine produced by skeletal muscle during exercise, ame-liorates obesity and metabolic abnormalities through multiple signal pathways. This paper reviews the relationship between irisin with obesity and related metabolic diseases, including type 2 dia-betes, atherosclerotic cardiovascular disease, non-alcoholic fatty liver disease and osteoporosis, with the aim of clarifying the regulatory mechanisms of irisin in metabolic target organs and ex-ploring new therapeutic pathways for obesity and related metabolic diseases.
文章引用:张怡宁, 尹晓. 鸢尾素在肥胖及相关代谢性疾病中的研究进展[J]. 临床医学进展, 2023, 13(12): 20104-20113. https://doi.org/10.12677/ACM.2023.13122830

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