儿童迁延性细菌性支气管炎研究进展
Research Progress of Protracted Bacterial Bronchitis in Children
DOI: 10.12677/ACM.2023.13122852, PDF,   
作者: 颜 攀, 应林燕*:重庆医科大学附属儿童医院呼吸科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,重庆
关键词: 儿童迁延性细菌性支气管炎研究进展Children Protracted Bacterial Bronchitis Research Progress
摘要: 迁延性细菌性支气管炎(Protracted Bacterial Bronchitis, PBB)是指由细菌引起的支气管内膜持续的感染,是国内外儿童慢性湿咳的常见病因之一,通常在口服2周有效的抗生素后症状可缓解;目前研究认为PBB、慢性化脓性肺疾病(Chronic Suppurative Lung Disease, CSLD)、支气管扩张(Bronchiectasis, BE)是同一疾病进展的三个不同阶段。提高对PBB认识有助于对儿童CSLD、BE的早期识别及干预,对改善预后至关重要。现就近年来有关PBB的病原学、发病机制、共患病、治疗及预后等研究进展进行综述。
Abstract: Protracted bacterial bronchitis (PBB) refers to persistent infection of the bronchial lining caused by bacteria, which is one of the common causes of chronic wet cough in children at home and abroad, and symptoms usually relieves after 2 weeks of oral antibiotics. At present, PBB, chronic suppura-tive lung disease (CSLD) and bronchiectasis (BE) are considered to be the three different stages of the progression of the same disease. Improving the awareness of PBB contributes to the early iden-tification and intervention of CSLD and BE in children is crucial to improving the prognosis. The eti-ology, pathogenesis, comorbidities, treatment and prognosis of PBB are reviewed.
文章引用:颜攀, 应林燕. 儿童迁延性细菌性支气管炎研究进展[J]. 临床医学进展, 2023, 13(12): 20260-20266. https://doi.org/10.12677/ACM.2023.13122852

参考文献

[1] Benscoter, D.T. (2018) Bronchiectasis, Chronic Suppurative Lung Disease and Protracted Bacterial Bronchitis. Current Problems in Pediatric and Adolescent Health Care, 48, 119-123. [Google Scholar] [CrossRef] [PubMed]
[2] Chang, A.B., Robertson, C.F., Van Asperen, P.P., et al. (2012) A Multicenter Study on Chronic Cough in Children: Burden and Etiologies Based on a Stand-ardized Management Pathway. Chest, 142, 943-950. [Google Scholar] [CrossRef] [PubMed]
[3] O’Grady, K.F., Drescher, B.J., Goyal, V., et al. (2017) Chronic Cough Postacute Respiratory Illness in Children: A Cohort Study. Archives of Disease in Childhood, 102, 1044-1048. [Google Scholar] [CrossRef] [PubMed]
[4] 陈强, 胡次浪, 申昆玲, 等. 儿童慢性湿性咳嗽病因构成比多中心研究[J]. 中国实用儿科杂志, 2019, 34(9): 757- 762+784.
[5] Morice, A.H., Millqvist, E., Bieksiene, K., et al. (2020) ERS Guidelines on the Diagnosis and Treatment of Chronic Cough in Adults and Children. European Respiratory Journal, 55, Article 1901136. [Google Scholar] [CrossRef] [PubMed]
[6] Kantar, A., Chang, A.B., Shields, M.D., et al. (2017) ERS Statement on Pro-tracted Bacterial Bronchitis in Children. European Respiratory Journal, 50, Article 1602139. [Google Scholar] [CrossRef] [PubMed]
[7] Zhang, X.B., Wu, X. and Nong, G.M. (2020) Update on Protracted Bacterial Bronchitis in Children. Italian Journal of Pediatrics, 46, Article No. 38. [Google Scholar] [CrossRef] [PubMed]
[8] Van der Gast, C.J., Cuthbertson, L., Rogers, G.B., et al. (2014) Three Clinically Distinct Chronic Pediatric Airway Infections Share a Common Core Microbiota. Annals of the American Thoracic Society, 11, 1039-1048. [Google Scholar] [CrossRef
[9] Huang, L., Lai, K., Zhan, C., et al. (2023) Clinical Characteristics of Protracted Bacterial Bronchitis in Adults. Heliyon, 9, e12299. [Google Scholar] [CrossRef] [PubMed]
[10] Wurzel, D.F., Marchant, J.M., Yerkovich, S.T., et al. (2016) Protracted Bacterial Bronchitis in Children: Natural History and Risk Factors for Bron-chiectasis. Chest, 150, 1101-1108. [Google Scholar] [CrossRef] [PubMed]
[11] Ruffles, T.J.C., Marchant, J.M., Masters, I.B., et al. (2021) Outcomes of Protracted Bacterial Bronchitis in Children: A 5-Year Prospective Cohort Study. Respirology, 26, 241-248. [Google Scholar] [CrossRef] [PubMed]
[12] Wurzel, D.F., Marchant, J.M., Yerkovich, S.T., et al. (2014) Prospective Char-acterization of Protracted Bacterial Bronchitis in Children. Chest, 145, 1271-1278. [Google Scholar] [CrossRef] [PubMed]
[13] Wang, Y., Hao, C., Ji, W., et al. (2019) Detecting Respiratory Viruses in Children with Protracted Bacterial Bronchitis. Respiratory Medicine, 151, 55-58. [Google Scholar] [CrossRef] [PubMed]
[14] Marsh, R.L., Smith-Vaughan, H.C., Chen, A.C.H., et al. (2019) Multiple Respiratory Microbiota Profiles Are Associated with Lower Airway Inflammation in Children with Protracted Bacterial Bronchitis. Chest, 155, 778-786. [Google Scholar] [CrossRef] [PubMed]
[15] 王宇清, 郝创利. 儿童迁延性细菌性支气管炎的定义及发病机制[J]. 中华实用儿科临床杂志, 2018, 33(10): 723- 727.
[16] Ntesou, D., Douros, K., Tsiambas, E., et al. (2021) Impact of Im-mune-Inflammatory Microenvironment Alterations on the Bronchial Lumen of Children with Protracted Bacterial Bronchitis. Cureus, 13, e20554. [Google Scholar] [CrossRef] [PubMed]
[17] 张倩, 李渠北. 迁延性细菌性支气管炎发病机制研究进展[J]. 国际儿科学杂志, 2021, 48(1): 35-38.
[18] Murayama, K., Ikegami, I., Kamekura, R., et al. (2022) CD4(+)CD8(+) T Follicular Helper Cells Regulate Humoral Immunity in Chronic Inflammatory Lesions. Frontiers in Immunology, 13, Article No. 941385. [Google Scholar] [CrossRef] [PubMed]
[19] Wang, Y., Hao, C., Chi, F., et al. (2015) Clinical Characteristics of Protracted Bacterial Bronchitis in Chinese Infants. Scientific Reports, 5, Article No. 13731. [Google Scholar] [CrossRef] [PubMed]
[20] Kantar, A. and Seminara, M. (2019) Why Chronic Cough in Children Is Different. Pulmonary Pharmacology & Therapeutics, 56, 51-55. [Google Scholar] [CrossRef] [PubMed]
[21] Bao, Y., Li, Y., Qiu, C., et al. (2018) Bronchoalveolar Lavage Fluid Microbiota Dysbiosis in Infants with Protracted Bacterial Bronchitis. Journal of Thoracic Disease, 10, 168-174. [Google Scholar] [CrossRef] [PubMed]
[22] 李岚, 刘恩梅, 郝创利, 等. 儿童及迁延性细菌性支气管炎临床诊治的前瞻性多中心研究[J]. 江西医药, 2021, 56(2): 168-172+186.
[23] Goyal, V., Grimwood, K., Marchant, J., et al. (2014) Does Failed Chronic Wet Cough Response to Antibiotics Predict Bronchiectasis? Archives of Disease in Childhood, 99, 522-525. [Google Scholar] [CrossRef] [PubMed]
[24] Cabrera, R., Fernández-Barat, L., Vázquez, N., et al. (2022) Resistance Mechanisms and Molecular Epidemiology of Pseudomonas aeruginosa Strains from Patients with Bronchiectasis. Journal of Antimi-crobial Chemotherapy, 77, 1600- 1610. [Google Scholar] [CrossRef] [PubMed]
[25] (2021) How to Manage Protracted Bacterial Bronchitis. Archives of Disease in Childhood, 106, 1074. [Google Scholar] [CrossRef] [PubMed]
[26] Ruffles, T.J.C., Goyal, V., Marchant, J.M., et al. (2021) Duration of Amoxicillin-Clavulanate for Protracted Bacterial Bronchitis in Children (DACS): A Multi-Centre, Double Blind, Randomised Con-trolled Trial. The Lancet Respiratory Medicine, 9, 1121-1129. [Google Scholar] [CrossRef
[27] Gross-Hodge, E., Carroll, W.D., Rainford, N., et al. (2020) Duration of Initial Antibiotic Course Is Associated with Recurrent Relapse in Protracted Bacterial Bronchitis. Archives of Disease in Childhood, 105, 1111-1113. [Google Scholar] [CrossRef] [PubMed]
[28] Chang, A.B., Oppenheimer, J.J., Weinberger, M.M., et al. (2017) Man-agement of Children with Chronic Wet Cough and Protracted Bacterial Bronchitis: CHEST Guideline and Expert Panel Report. Chest, 151, 884-890. [Google Scholar] [CrossRef] [PubMed]
[29] 傅大干, 李海霞, 周伟, 等. 细菌溶解产物防治儿童迁延性细菌性支气管炎疗效研究[J]. 临床肺科杂志, 2022, 27(9): 1312-1316.
[30] 刘静月, 付文龙, 耿刚. 支气管镜在儿童迁延性细菌性支气管炎中的应用价值[J]. 重庆医科大学学报, 2022, 47(9): 1069-1073.
[31] Zhang, R., Wang, L., Gong, C., et al. (2023) Associated Risk Factors and Diagnostic Value of Fiberoptic Bronchoscopy for Protracted Bacterial Bronchitis in Children. International Journal of Clinical Practice, 2023, Article ID: 8116651. [Google Scholar] [CrossRef] [PubMed]
[32] 范立东, 李志军, 马增光. 阿莫西林克拉维酸钾联合枳桔二陈汤治疗儿童迁延性细菌性支气管炎的效果观察及对炎性因子、免疫功能的影响[J]. 临床误诊误治, 2020, 33(10): 49-52.
[33] 李想, 赵娇, 陆敏, 等. 中西医结合治疗儿童迁延性细菌性支气管炎疗效的Meta分析[J]. 医学信息, 2021, 34(17): 101-106.
[34] O’Grady, K.F., Chang, A.B., Cripps, A., et al. (2018) The Clinical, Immunological and Microbiological Impact of the 10-Valent Pneumococcal-Protein D Conjugate Vaccine in Children with Recurrent Protracted Bacterial Bronchitis, Chronic Suppurative Lung Disease and Bronchiectasis: A Multi-Centre, Double-Blind, Randomised Controlled Trial. Human Vaccines & Immunotherapeuticsr, 14, 2768-2779. [Google Scholar] [CrossRef] [PubMed]
[35] Armstrong, D. (2021) Long-Term Follow-Up of Children with Protracted Bacterial Bronchitis: Some Answers, and More Questions. Respirology, 26, 218-219. [Google Scholar] [CrossRef] [PubMed]