近五年阿尔兹海默病相关生物标志物的研究——基于WOSCC数据库的CiteSpace文献计量分析
Research on Alzheimer’s Disease-Related Biomarkers in the Past Five Years—CiteSpace Bibliometric Analysis Based on WOSCC Database
DOI: 10.12677/SA.2023.126174, PDF,    科研立项经费支持
作者: 蒋 静*, 张咏芝*, 蔡 玲, 陈宇菲, 吕美红#, 木本荣#：成都中医药大学医学技术学院，四川 成都；川渝共建感染性疾病中西医结合诊治重庆市重点实验室，四川 成都
关键词: 阿尔兹海默病；生物标志物；WOSCC；CiteSpace；文献计量分析；Alzheimer’s Disease； Biomarkers； WOSCC； CiteSpace； Bibliometric Analysis
摘要: 目的：阿尔兹海默病(Alzheimer’s Disease, AD)给患者、社会带来了巨大的负担，生物标志物可以在AD的早期诊断中发挥作用，帮助预防和治疗AD，并具有显著缓解疾病进展的潜力。本文采用文献计量分析的方法，分析AD生物标志物的研究现状、热点和趋势。方法：以Web of Science Core Collection (WOSCC)为数据来源，检索2018年10月27日~2023年10月27日出版的阿尔兹海默症生物标志物研究的相关论文，应用CiteSpace 6.2.R4软件对关键词、国家、作者、机构等进行可视化分析。结果：共获得5346篇文献，年度发文量总体呈现上升趋势，共有97个发文国家/地区和296个发文机构，其中以美国(1972篇)和伦敦大学(518篇)发文量最多，共有285位发文作者，292本被引期刊，获得297个关键词，25个突现词，9个聚类，其聚类标签包括tau蛋白水平、认知力下降、脑脊液生物标志物等。结论：目前，国际上对AD生物标志物的研究仍在不断增加，脑脊液、血液标志物仍是研究重点，未来如何建立合适的标志物组合将会成为AD的研究热点，可为AD的诊断和治疗提供更加有效的手段。
Abstract: Objective: Alzheimer’s Disease (AD) imposes a huge burden on patients and society, and bi-omarkers can play the role of early diagnosis in AD diagnosis, help to prevent and treat AD, and have the potential to significantly alleviate disease progression. In this paper, bibliometric analysis was used to analyze the research status, hotspots and trends of AD biomarkers. Methods: The Web of Science Core Collection (WOSCC) was used as the data source to retrieve relevant papers on Alz-heimer’s disease biomarker research published from October 27, 2018 to October 27, 2023, and CiteSpace 6.2.R4 software was used to visually analyze keywords, countries, authors, institutions, etc. Results: A total of 5346 articles were obtained, and the annual number of papers showed an overall upward trend, with a total of 97 countries/regions and 296 institutions, among which, the United States (1972 articles) and the University of London (518 articles) had the largest number of papers, with a total of 285 authors, 292 cited journals, 297 keywords, 25 emergent words, and 9 clusters, and their cluster tags included tau protein level, cognitive decline, cerebrospinal fluid bi-omarkers, etc. Conclusion: At present, the international research on AD biomarkers is still increas-ing, cerebrospinal fluid and blood markers are still the focus of research, and how to establish ap-propriate marker combinations in the future will become a research hotspot for AD, which can pro-vide more effective means for the diagnosis and treatment of AD.
文章引用：蒋静, 张咏芝, 蔡玲, 陈宇菲, 吕美红, 木本荣. 近五年阿尔兹海默病相关生物标志物的研究——基于WOSCC数据库的CiteSpace文献计量分析[J]. 统计学与应用, 2023, 12(6): 1707-1717. https://doi.org/10.12677/SA.2023.126174

参考文献

[1] Zetterberg, H. (2017) Applying Fluid Biomarkers to Alzheimer’s Disease. American Journal of Physiology-Cell Physiology, 313, C3-C10. [Google Scholar] [CrossRef] [PubMed]
[2] 翟雅莉, 贾新, 王晓明. 阿尔茨海默病的药物治疗进展[J]. 国际老年医学杂志, 2023, 44(5): 605-608.
[3] 李珊珊, 张晓玲. 基于CiteSpace可视化分析阿尔茨海默病生物标记物研究进展[J]. 中国预防医学杂志, 2021, 22(4): 288-296.
[4] DeTure, M.A. and Dickson, D.W. (2019) The Neuropathological Diagnosis of Alz-heimer’s Disease. Molecular Neurodegeneration, 14, Article No. 32. [Google Scholar] [CrossRef] [PubMed]
[5] Chen, C.M., et al. (2012) Emerging Trends in Regenerative Medicine: A Scientometric Analysis in CiteSpace. Expert Opinion on Biological Therapy, 12, 593-608. [Google Scholar] [CrossRef] [PubMed]
[6] 杜瑞琥, 王飒, 张晓峰. 近十年小胶质细胞与阿尔茨海默病相关性研究进展——基于CiteSpace文献计量分析[J]. 毒理学杂志, 2021, 35(6): 496-500.
[7] Gonzalez-Ortiz, F., Turton, M., Kac, P.R., Smirnov, D., Premi, E., Ghidoni, R., et al. (2023) Brain-Derived Tau: A Novel Blood-Based Biomarker for Alzheimer’s Disease-Type Neurodegeneration. Brain, 146, 1152-1165. [Google Scholar] [CrossRef] [PubMed]
[8] Mattsson, N., Zetterberg, H., Hansson, O., et al. (2009) CSF Biomarkers and Incipi-ent Alzheimer Disease in Patients with Mild Cognitive Impairment. The Journal of the American Medical Association, 302, 385-393.
[9] Hampel, H., Lista, S. and Khachaturian, Z.S. (2012) Development of Biomarkers to Chart All Alzheimer’s Disease Stages: The Royal Road to Cutting the Therapeutic Gordian Knot. Alzheimer’s & Dementia, 8, 312-336. [Google Scholar] [CrossRef] [PubMed]
[10] Palmqvist, S., Insel, P.S., Stomrud, E., et al. (2019) Cerebrospinal Fluid and Plasma Biomarker Trajectories with Increasing Amyloid Deposition in Alzheimer’s Disease. EMBO Molecular Medicine, 11, e11170. [Google Scholar] [CrossRef] [PubMed]
[11] 宋博雅. 阿尔兹海默症发病机制的研究进展[J]. 西安文理学院学报(自然科学版), 2020, 23(4): 77-79+92.
[12] Hoe, H.S., Freeman, J. and Rebeck, G.W. (2006) Apolipoprotein E Decreases Tau Kinases and Phospho-Tau Levels in Primary Neurons. Molecular Neurodegeneration, 1, Article No. 18. [Google Scholar] [CrossRef] [PubMed]
[13] Guo, T.T., Zhang, D.H., Zeng, Y.Z., Huang, T.Y., Xiu, H.X. and Zhao, Y.J. (2020) Molecular and Cellular Mechanisms Underlying the Pathogenesis of Alzheimer’s Disease. Molecular Neurodegeneration, 15, Article No. 40. [Google Scholar] [CrossRef] [PubMed]
[14] Nam, E., Lee, Y.B., Moon, C. and Chang, K.A. (2020) Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer’s Disease Progression. International Journal of Molecular Sciences, 21, 5007-5026. [Google Scholar] [CrossRef] [PubMed]
[15] Park, J.C., Han, S.H., Yi, D., Byun, M.S., Lee, J.H., Jang, S., Ko, K., Jeon, S.Y., Lee, Y.S., Kim, Y.K., Lee, D.Y. and Jung, I.M. (2019) Plasma Tau/Amyloid-β1-42 Ratio Predicts Brain Tau Deposition and Neurodegenera-tion in Alzheimer’s Disease. Brain, 142, 771-786. [Google Scholar] [CrossRef] [PubMed]
[16] Verghese, P.B., Castellano, J.M., Garai, K., Wang, Y., Jiang, H., Shah, A., Bu, G., Frieden, C. and Holtzman, D.M. (2013) ApoE Influences Amyloid-β (Aβ) Clearance despite Minimal apoE/Aβ Association in Physiological Conditions. Proceedings of the National Academy of Sciences of the United States of America, 110, E1807-E1816. [Google Scholar] [CrossRef] [PubMed]
[17] 李亮, 薛星莉, 李亚芹, 李欢, 潘宝龙, 牛侨. 亚慢性铝染毒对转人载脂蛋白E4基因小鼠β-淀粉样蛋白含量及低密度脂蛋白家族的影响[J]. 环境与职业医学, 2020, 37(2): 103-110.
[18] Lanfranco, M.F., Ng, C.A. and Rebeck, G.W. (2020) ApoE Lipidation as a Therapeutic Target in Alzheimer’s Disease. International Journal of Molecu-lar Sciences, 21, Article 6336. [Google Scholar] [CrossRef] [PubMed]
[19] 杜红坚. 阿尔茨海默病载脂蛋白E基因多态性及神经电生理研究[D]: [博士学位论文]. 天津: 天津医科大学, 2002.
[20] Wernette-Hammond, M.E., Lauer, S.J., Corsini, A., Walker, D., Taylor, J.M. and Rall, S.C. (1989) Glycosylation of Human Apolipoprotein E. The Carbohydrate Attachment Site Is Threonine 194. Journal of Biological Chemistry, 264, 9094-9101. [Google Scholar] [CrossRef] 
[21] Nikolac Perkovic, M. and Pivac, N. (2019) Genetic Markers of Alzheimer’s Disease. In: Kim, Y.K., Ed., Frontiers in Psychiatry. Advances in Experimental Medicine and Biology, Vol. 1192, Springer, Singapore, 27-52. [Google Scholar] [CrossRef] [PubMed]
[22] Minta, K., Brinkmalm, G., Janelidze, S., Sjödin, S., Portelius, E., Stomrud, E., Zetterberg, H., Blennow, K., Hansson, O. and Andreasson, U. (2020) Quantification of Total Apolipoprotein E and Its Isoforms in Cerebrospinal Fluid from Patients with Neurodegenerative Diseases. Alzheimer’s Research & Therapy, 12, Article No. 19. [Google Scholar] [CrossRef] [PubMed]
[23] 白茹, 何婷, 谢能. 阿尔兹海默病诊断标志物的研究进展[J]. 河北医药, 2023, 45(9): 1391-1395.
[24] Ashton, N., Janelidze, S., Al Khleifat, A., et al. (2020) Diagnostic Value of Plasma Neurofilament Light: A Multicentre Validation Study. [Google Scholar] [CrossRef] 
[25] Middeldorp, J. and Hol, E.M. (2011) GFAP in Health and Disease. Progress in Neurobiology, 93, 421-443. [Google Scholar] [CrossRef] [PubMed]
[26] Kim, K.Y., Shin, K.Y. and Chang, K.A. (2023) GFAP as a Potential Bi-omarker for Alzheimer’s Disease: A Systematic Review and Meta-Analysis. Cells, 12, Article 1309. [Google Scholar] [CrossRef] [PubMed]
[27] Xiang, Y., Xin, J., Le, W. and Yang, Y. (2020) Neurogranin: A Potential Biomarker of Neurological and Mental Diseases. Frontiers in Aging Neuroscience, 12, Article ID: 584743. [Google Scholar] [CrossRef] [PubMed]
[28] Lista, S. and Hampel, H. (2017) Synaptic Degeneration and Neurogranin in the Pathophysiology of Alzheimer’s Disease. Expert Review of Neurotherapeutics, 17, 47-57. [Google Scholar] [CrossRef] [PubMed]

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