甘油三酯葡萄糖指数与心血管疾病关系的研究进展
Research Progress on the Relationship between Triglyceride-Glucose Index and Cardiovascular Disease
DOI: 10.12677/ACM.2023.13122865, PDF,    科研立项经费支持
作者: 陈艳丽:新疆医科大学第四临床医学院,新疆 乌鲁木齐;帕尔哈提·吐尔逊*:新疆医科大学附属中医医院心内科,新疆 乌鲁木齐
关键词: 甘油三酯葡萄糖指数胰岛素抵抗心血管疾病Triglyceride Glucose Index Insulin Resistance Cardiovascular Disease
摘要: 甘油三酯葡萄糖指数已被确定为胰岛素抵抗的简易灵敏可靠替代生物标志物。大量研究表明甘油三酯葡萄糖指数与心血管疾病的发展和预后相关,对心血管疾病患者的早期筛查、危险分层也有潜在判断能力。然而,甘油三酯葡萄糖指数作为心血管疾病标志物的应用尚未得到系统评估,关于心血管疾病相关潜在机制的信息更少。因此,本文就甘油三酯葡萄糖指数在各种心血管疾病类型中的应用价值及最新研究进展做一综述。
Abstract: The triglyceride glucose (TyG) index has been identified as a simple sensitive and reliable alterna-tive biomarker for insulin resistance. A large number of studies have shown that TyG index is re-lated to the development and prognosis of cardiovascular diseases (CVD), and it also has potential judgment ability for early screening and risk stratification of patients with CVD. However, the use of TyG index as a marker of CVD has not been systematically evaluated, and there is even less infor-mation about the underlying mechanisms associated with CVD. Therefore, this article reviews the application value and latest research progress of TyG index in various types of CVD.
文章引用:陈艳丽, 帕尔哈提·吐尔逊. 甘油三酯葡萄糖指数与心血管疾病关系的研究进展[J]. 临床医学进展, 2023, 13(12): 20350-20355. https://doi.org/10.12677/ACM.2023.13122865

参考文献

[1] Yusuf, S., Joseph, P., Rangarajan, S., et al. (2020) Modifiable Risk Factors, Cardiovascular Disease, and Mortality in 155 722 Individuals from 21 High-Income, Middle-Income, and Low-Income Countries (PURE), a Prospective Cohort Study. The Lancet, 395, 795-808. [Google Scholar] [CrossRef
[2] 马丽媛, 王增武, 樊静, 等. 《中国心血管健康与疾病报告2021》概要[J]. 中国介入心脏病学杂志, 2022, 30(7): 481-496.
[3] Rosenblit, P.D. (2019) Extreme Atherosclerotic Cardiovascular Disease (ASCVD) Risk Recognition. Current Diabetes Reports, 19, Article No. 61. [Google Scholar] [CrossRef] [PubMed]
[4] Choi, S. (2019) The Potential Role of Bi-omarkers Associated with ASCVD Risk: Risk-Enhancing Biomarkers. Journal of Lipid and Atherosclerosis, 8, 173-182. [Google Scholar] [CrossRef] [PubMed]
[5] Deedwania, P., Murphy, S.A., Scheen, A., et al. (2021) Efficacy and Safety of PCSK9 Inhibition with Evolocumab in Reducing Cardiovascular Events in Patients with Metabolic Syndrome Receiving Statin Therapy: Secondary Analysis From the FOURIER Randomized Clinical Trial. JAMA Cardiology, 6, 139-147. [Google Scholar] [CrossRef] [PubMed]
[6] Ridker, P.M., Rifai, N., Rose, L., et al. (2002) Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events. The New England Journal of Medicine, 347, 1557-1565. [Google Scholar] [CrossRef
[7] Tong, X.W., Zhang, Y.T., Yu, Z.W., et al. (2022) Triglyceride Glu-cose Index Is Related with the Risk of Mild Cognitive Impairment in Type 2 Diabetes. Diabetes, Metabolic Syndrome and Obesity, 15, 3577-3587. [Google Scholar] [CrossRef
[8] Steven, S., Frenis, K., Oelze, M., et al. (2019) Vascular Inflamma-tion and Oxidative Stress: Major Triggers for Cardiovascular Disease. Oxidative Medicine and Cellular Longevity, 2019, Article ID: 7092151. [Google Scholar] [CrossRef] [PubMed]
[9] Son, D.H., Lee, H.S., Lee, Y.J., et al. (2022) Comparison of Triglycer-ide-Glucose Index and HOMA-IR for Predicting Prevalence and Incidence of Metabolic Syndrome. Nutrition, Metabo-lism and Cardiovascular Diseases, 32, 596-604. [Google Scholar] [CrossRef] [PubMed]
[10] Tahapary, D.L., Pratisthita, L.B., Fitri, N.A., et al. (2022) Chal-lenges in the Diagnosis of Insulin Resistance: Focusing on the Role of HOMA-IR and Tryglyceride/Glucose Index. Di-abetology Metabolic Syndrome, 16, Article 102581. [Google Scholar] [CrossRef] [PubMed]
[11] Kelley, D.E., Goodpaster, B.H. and Storlien, L. (2002) Muscle Tri-glyceride and Insulin Resistance. Annual Review of Nutrition, 22, 325-346. [Google Scholar] [CrossRef] [PubMed]
[12] 艾比班木•艾则孜, 马依彤. 甘油三酯葡萄糖指数与心血管疾病及代谢综合征相关性的研究进展[J]. 中华老年多器官疾病杂志, 2022, 21(4): 317-320.
[13] 赵能江, 张智海, 陈薇, 等. 《中国2型糖尿病防治指南(2020年版)》亮点解读及糖尿病中医指南分析[J]. 中国中西医结合杂志, 2021, 41(6): 652-655.
[14] Zhang, M., Wang, B., Liu, Y., et al. (2017) Cumulative Increased Risk of In-cident Type 2 Diabetes Mellitus with Increasing Triglyceride Glucose Index in Normal-Weight People: The Rural Chi-nese Cohort Study. Cardiovascular Diabetology, 16, Article No. 30. [Google Scholar] [CrossRef] [PubMed]
[15] Navarro-González, D., Sánchez-Íñigo, L., Pastrana-Delgado, J., et al. (2016) Triglyceride-Glucose Index (TyG Index) in Comparison with Fasting Plasma Glucose Improved Diabetes Pre-diction in Patients with Normal Fasting Glucose: The Vascular-Metabolic CUN Cohort. Preventive Medicine, 86, 99-105. [Google Scholar] [CrossRef] [PubMed]
[16] 中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2019概要[J]. 中华老年病研究电子杂志, 2020, 7(4): 4-15.
[17] Farrukh, F., Abbasi, A., Jawed, M., et al. (2022) Hypertension in Women: A South-Asian Perspective. Frontiers in Cardiovascular Medicine, 9, Article 880374. [Google Scholar] [CrossRef] [PubMed]
[18] Olsen, M.H., Angell, S.Y., Asma, S., et al. (2016) A Call to Ac-tion and a Lifecourse Strategy to Address the Global Burden of Raised Blood Pressure on Current and Future Genera-tions: The Lancet Commission on Hypertension. The Lancet, 388, 2665-2712. [Google Scholar] [CrossRef
[19] Mao, Q., Zhou, D., Li, Y., et al. (2019) The Triglycer-ide-Glucose Index Predicts Coronary Artery Disease Severity and Cardiovascular Outcomes in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome. Disease Markers, 2019, Article ID: 6891537. [Google Scholar] [CrossRef] [PubMed]
[20] Zhao, Q., Zhang, T.Y., Cheng, Y.J., et al. (2020) Impacts of Triglycer-ide-Glucose Index on Prognosis of Patients with Type 2 Diabetes Mellitus and Non-ST-Segment Elevation Acute Coro-nary Syndrome: Results from an Observational Cohort Study in China. Cardiovascular Diabetology, 19, Article No. 108. [Google Scholar] [CrossRef] [PubMed]
[21] Hudzik, B., Budaj, A., Gierlotka, M., et al. (2020) Assess-ment of Quality of Care of Patients with ST-Segment Elevation Myocardial Infarction. European Heart Journal. Acute Cardiovascular Care, 9, 893-901. [Google Scholar] [CrossRef] [PubMed]
[22] Luo, E., Wang, D., Yan, G., et al. (2019) High Triglycer-ide-Glucose Index Is Associated with Poor Prognosis in Patients with Acute ST-Elevation Myocardial Infarction after Percutaneous Coronary Intervention. Cardiovascular Diabetology, 18, Article No. 150. [Google Scholar] [CrossRef] [PubMed]
[23] Brosolo, G., Da Porto, A., Bulfone, L., et al. (2022) Insulin Re-sistance and High Blood Pressure: Mechanistic Insight on the Role of the Kidney. Biomedicines, 10, Article 2374. [Google Scholar] [CrossRef] [PubMed]
[24] Kong, G., Chew, N., Ng, C.H., et al. (2022) Long-Term Out-comes in Acute Coronary Syndrome Patients without Standard Modifiable Risk Factors: A Multi-Ethnic Retrospective Cohort Study of 5400 Asian Patients. Journal of Thrombosis and Thrombolysis, 54, 569-578. [Google Scholar] [CrossRef] [PubMed]
[25] Thai, P.V., Tien, H.A., Van Minh, H., et al. (2020) Triglyceride Glucose Index for the Detection of Asymptomatic Coronary Artery Stenosis in Patients with Type 2 Diabetes. Cardio-vascular Diabetology, 19, Article No. 137. [Google Scholar] [CrossRef] [PubMed]
[26] María, M., Ameneiros-Rodríguez, E., et al. (2019) Insulin Re-sistance Is Associated with Subclinical Vascular Disease in Humans. World Journal of Diabetes, 10, 63-77. [Google Scholar] [CrossRef] [PubMed]
[27] Jiang, Z., Zhu, J., Shen, H., et al. (2022) A High Triglyceride-Glucose Index Value Is Associated with an Increased Risk of Carotid Plaque Burden in Subjects with Prediabetes and New-Onset Type 2 Diabetes: A Real-World Study. Frontiers in Cardiovascular Medicine, 9, Article 832491. [Google Scholar] [CrossRef] [PubMed]
[28] Roger, V.L. (2021) Epidemiology of Heart Failure: A Contempo-rary Perspective. Circulation Research, 128, 1421-1434. [Google Scholar] [CrossRef
[29] Yang, C.D., Pan, W.Q., Feng, S., et al. (2022) Insulin Resistance Is Associated with Heart Failure with Recovered Ejection Fraction in Patients without Diabetes. Journal of the American Heart Association, 11, e026184. [Google Scholar] [CrossRef
[30] Guo, W., Zhao, L., Mo, F., et al. (2021) The Prognostic Value of the Triglyceride Glucose Index in Patients with Chronic Heart Failure and Type 2 Diabetes: A Retrospective Cohort Study. Diabetes Research and Clinical Practice, 177, Article 108786. [Google Scholar] [CrossRef] [PubMed]
[31] 陈丹丹, 张慧, 邵静, 等. 代谢综合征患者饮食和运动管理方案最佳证据总结[J]. 浙江大学学报: 医学版, 2022, 51(1): 27-37.
[32] Liu, J., Liu, Q., Li, Z., et al. (2022) Preva-lence of Metabolic Syndrome and Risk Factors among Chinese Adults: Results from a Population-Based Study—Beijing, China, 2017-2018. China CDC Weekly, 4, 640-645.
[33] Huang, Y., Zhang, L., Wang, Z., et al. (2022) The Prevalence and Characteristics of Metabolic Syndrome According to Different Definitions in China: A Nationwide Cross-Sectional Study, 2012-2015. BMC Public Health, 22, Article No. 1869. [Google Scholar] [CrossRef] [PubMed]
[34] Bovolini, A., Garcia, J., Andrade, M.A., et al. (2021) Metabolic Syndrome Pathophysiology and Predisposing Factors. International Journal of Sports Medicine, 42, 199-214. [Google Scholar] [CrossRef] [PubMed]
[35] Koca, N., Ayar, K., Bal, Ö., et al. (2021) The Evaluation of the Role of BMI and Insulin Resistance on Inflammatory Markers, PAI-1 Levels and Arterial Stiffness in Newly Diagnosed Type 2 Diabetes Mellitus Patients. Minerva Endocrinology (Torino), 46, 116-123. [Google Scholar] [CrossRef