血清IGF-1的临床应用进展
Progress in Clinical Application of Serum IGF-1
DOI: 10.12677/ACM.2023.13122869, PDF,   
作者: 王馨爽:新疆医科大学,新疆 乌鲁木齐 ;郭艳英*:新疆维吾尔自治区人民医院内分泌科,新疆 乌鲁木齐
关键词: 胰岛素样生长因子1作用临床应用进展Insulin-Like Growth Factor 1 Function Clinical Application Progress
摘要: 胰岛素样生长因子1 (Insulin-Like Growth Factor I, IGF-1)是一类多功能细胞增殖调控因子,其化学结构与胰岛素原相似,故因此命名。IGF-1主要在肝脏合成,其合成过程主要受生长激素(growth hormone, GH)调控。血清IGF-1的水平主要与循环中的GH水平、年龄有关,对人体生长发育、代谢、免疫调节、认知水平发挥了重要作用。对成人血清IGF-1检测在肢端肥大症的诊断及预后、成人生长激素缺乏症的诊治、肿瘤筛查及检测和监测心血管疾病预后起到重要作用。
Abstract: Insulin-like growth factor 1 (IGF-1) is a multifunctional cell proliferation regulator, and its chemical structure is similar to proinsulin, so it is named. IGF-1 is mainly synthesized in the liver, and its synthesis process is mainly regulated by growth hormone (GH). Serum IGF-1 level is mainly related to circulating GH level and age, which plays an important role in human growth, metabolism, im-mune regulation and cognitive level. It plays an important role in the diagnosis and prognosis of adult serum IGF-1 in acromegaly, the diagnosis and treatment of adult growth hormone deficiency, tumor screening, detection and monitoring the prognosis of cardiovascular diseases.
文章引用:王馨爽, 郭艳英. 血清IGF-1的临床应用进展[J]. 临床医学进展, 2023, 13(12): 20374-20379. https://doi.org/10.12677/ACM.2023.13122869

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