溃疡性结肠炎复发相关营养代谢因素的研究进展

Research Progress on Nutritional Metabolic Factors Related to Recurrence of Ulcerative Colitis

摘要: 溃疡性结肠炎(Ulcerative colitis, UC)为炎症性肠病(inflammatory bowel disease, IBD)中常见的类型，在我国，它已成为消化系统常见的疾病之一，UC的主要临床特点是高复发率。然而，关于溃疡性结肠炎复发的具体原因，目前还不是很清楚，但可能与免疫反应、环境因素、营养代谢等多个方面有关。本文将依据目前国内外的研究热点，对临床常用的营养代谢指标，例如同型半胱氨酸、血糖水平、血脂浓度、维生素D、叶酸、体重指数等与溃疡性结肠炎复发之间关系的研究作一综述。能够发现上述指标与UC的关系复杂，营养代谢指标的改变与UC复发或其病情变化之间可能存在相互作用。因此，探求营养相关的因素对UC发病的影响及作用机制可能为UC的治疗提供新思路。

Abstract: Ulcerative colitis (UC) is a common type of inflammatory bowel disease (IBD). In China, it has be-come one of the common digestive system diseases, and the main clinical feature of UC is a high re-currence rate. However, the specific reasons for the recurrence of ulcerative colitis are not yet clear, but may be related to multiple aspects such as immune response, environmental factors, and nutri-tional metabolism. This article will review the research on the relationship between commonly used nutritional metabolism indicators in clinical practice, such as homocysteine, blood glucose levels, blood lipid concentrations, vitamin D, folic acid, body mass index, and recurrence of ulcerative coli-tis, based on current research hotspots both domestically and internationally. It can be found that the relationship between the above indicators and UC is complex, and there may be an interaction between changes in nutritional metabolism indicators and the recurrence of UC or changes in its condition. Therefore, exploring the impact and mechanism of nutrition related factors on the path-ogenesis of UC may provide new ideas for the treatment of UC.