放疗下肿瘤细胞凋亡行为的异质性研究

Heterogeneity Study of Apoptosis Behavior of Tumor Cells during Radiotherapy

摘要: 癌症作为21世纪威胁人类健康的重大疾病之一，一直是医学领域的研究热点。肿瘤体积的建模是反映临床治疗对肿瘤控制情况的重要指标之一，也是实现对肿瘤治疗过程监控的重要途径。要实现对肿瘤体积的建模，就必须对肿瘤体积的变化过程进行充分研究。肿瘤细胞凋亡行为是导致肿瘤在放疗期间体积发生变化的重要因素。本文从肿瘤的异质性出发，将肿瘤划分为了含氧区域与乏氧区域，通过对肿瘤的异质性区域的划分来区分了两类肿瘤细胞不同的凋亡行为，从而实现细胞凋亡行为的异质性建模。结果显示，该模型能够较好地模拟肿瘤在放疗后期的加速凋亡过程。

Abstract: As one of the major diseases threatening human health in the 21st century, the research of tumor has always been a hot topic in the medical field. Tumor volume is one of the important indicators reflecting the clinical treatment of tumor control. Modelling of tumor volume is an important way to achieve tumor monitoring. To achieve modeling of tumor volume, it is necessary to study the pro-cess of tumor volume changes. The apoptosis behavior of tumor cells is an important factor leading to changes in tumor volume during radiotherapy. From the perspective of tumor heterogeneity, this paper divides tumors into oxygen regions and hypoxic regions, and distinguishes the different cells loss between these two regions. The results show that the model can effectively simulate the accel-erated apoptosis process in the later stage of radiotherapy.