NO/cGMP通路对细胞凋亡机制的影响与抑郁症的关系综述
A Review of the Effect of the NO/cGMP Path-way on the Mechanism of Apoptosis and Its Relationship with Depression
DOI: 10.12677/ACM.2024.141048, PDF,    科研立项经费支持
作者: 吴 昊, 刘 派, 丁 鑫, 何 磊, 闫 萌, 陈晓梅, 钱占红*：内蒙古医科大学中医学院，内蒙古 呼和浩特
关键词: 抑郁症；细胞凋亡；NO；cGMP；PKG；Depression； Apoptosis； NO； cGMP； PKG
摘要: 抑郁症是危害人类身体健康的主要精神疾病之一，且发病率逐年上升。现有机制无法完全解释抑郁症的所有方面。细胞凋亡是细胞的一种程序性死亡，近年大量研究证明细胞凋亡与抑郁症的关系十分密切。而NO/cGMP通路在大量研究中不仅体现了其与抑郁症的联系，还体现了其与细胞凋亡的联系。在本文中，主要对抑郁症与细胞凋亡和NO/cGMP通路的关系进行了综述，包括抑郁症与细胞凋亡的联系、细胞凋亡与NO/cGMP通路的联系、以及通路与抑郁症的联系，从而为深入了解抑郁症的发病机制以及治疗提供参考。
Abstract: Depression is one of the major mental disorders that jeopardize human health and its incidence is increasing every year. Existing mechanisms cannot fully explain all aspects of depression. Apoptosis is a kind of programmed cell death, and a large number of studies in recent years have proved that apoptosis is very closely related to depression. And the NO/cGMP pathway has been demonstrated in a large number of studies not only in its connection with depression, but also in its connection with apoptosis. In this paper, the relationship between depression and apoptosis and NO/cGMP pathway is reviewed, including the link between depression and apoptosis, the link between apop-tosis and NO/cGMP pathway, and the link between the pathway and depression, so as to provide reference for an in-depth understanding of the pathogenesis as well as the treatment of depression.
文章引用：吴昊, 刘派, 丁鑫, 何磊, 闫萌, 陈晓梅, 钱占红. NO/cGMP通路对细胞凋亡机制的影响与抑郁症的关系综述[J]. 临床医学进展, 2024, 14(1): 326-331. https://doi.org/10.12677/ACM.2024.141048

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