卵巢储备功能减退相关研究进展

Related Research Progress in Diminished Ovarian Reserve

摘要: 随着晚婚、晚育女性人数逐年呈上升趋势，高龄女性妊娠比例及助孕需求也随之升高，即使个体间可能存在差异，但伴随的是卵巢储备功能大体呈下降趋势，导致女性生育力低下。卵巢储备功能减退(Diminished Ovarian Reserve, DOR)是一种强调卵巢储备的下降和对生育力的影响疾病，有8%~15%的女性受其影响。其病因复杂，包括社会人口危险因素、临床危险因素。目前国内外尚无统一诊断标准，但临床常将抗缪勒管激素、卵泡刺激素、窦卵泡数及年龄作为评估指标，具有生育能力下降，月经紊乱、性激素缺乏等表现。虽然国内外对DOR的治疗已进行大量探索和研究，但目前的治疗方式仍是以对症治疗、解决不孕需求为主。本文就卵巢储备功能减退相关背景对该病从定义、相关概念、临床表现、诊断及治疗进展进行概述，并从病理生理学、影响因素方面的研究进展展开综述，以期为DOR相关研究提供理论依据。

Abstract: As the number of women who marry late and have late childbirth increases year by year, the pro-portion of elderly women and the need for pregnancy assistance also increase. Even if there may be differences among individuals, the ovarian reserve is generally declining, leading to low fertility of women. Diminished Ovarian Reserve (DOR) is a disease that emphasizes the decline in ovarian re-serve and the impact on fertility, affecting 8% to 15% of women. Its etiology is complex, including sociodemographic risk factors and clinical risk factors. At present, there is no unified diagnostic standard at home and abroad, Anti-Mullerian Hormone (AMH), Follicle-Stimulating Hormone (FSH), Antral Follicle Count (AFC) and age are often used as the evaluation indicators of DOR, which char-acterized with decreased fertility, menstrual disorders, and sex hormone deficiency. Although the treatment of DOR has been extensively explored and studied, the current treatment is still focuses on symptomatic treatment and solving the needs of infertility. In this paper, we summarize the definition, related concepts, clinical manifestations, diagnosis and treatment of the background of DOR, and summarize the progress of pathophysiology and influencing factors, in order to provide a theoretical basis for DOR.