幽门螺旋杆菌感染与帕金森病关系的研究进展
Research Progress on the Relationship between Helicobacter pylori Infection and Parkinson’s Disease
DOI: 10.12677/ACM.2024.141074, PDF,   
作者: 郑雨端：新疆医科大学研究生学院，新疆 乌鲁木齐；阿不来提·艾则孜*：新疆维吾尔自治区人民医院全科医疗科，新疆 乌鲁木齐
关键词: 帕金森病；幽门螺旋杆菌；α-突触核蛋白；氧化应激；脑肠轴；Parkinson’s Disease； Helicobacter pylori； α-Synuclein； Oxidative Stress； Gut-Brain Axis
摘要: 帕金森病(Parkinson’s disease, PD)在神经退行性疾病中位居第二，其发病率仅低于阿尔兹海默症(Alzheimer’s disease, AD)，一直是当今人类社会面临的医学难题之一。大脑黑质致密部的多巴胺能神经元损失和细胞内蛋白–突触核蛋白聚集是其病理特征。多巴胺和乙酰胆碱发生失衡，从而导致PD的发生。随着研究深入，发现PD与幽门螺旋杆菌(Helicobacter pylori, HP)也有着紧密的联系。但是HP影响PD发生的确切病因及发病机制目前尚未明确。本篇综述对HP影响PD的相互关系及可能发病机制进行阐述，并对未来早期诊断、治疗HP及预后提供新的思路。
Abstract: Parkinson’s disease (PD) ranks second among neurodegenerative diseases, and the incidence is on-ly lower than Alzheimer’s disease (AD), and has always been one of the medical problems facing human society today. The loss of dopaminergic neurons and the aggregation of intracellular pro-tein-synuclein in the dense part of the substantia nigra are its pathological features. An imbalance occurs between dopamine and acetylcholine, which leads to the development of PD. As the research deepened, it was found that PD was also closely related to Helicobacter pylori (HP). However, the exact etiology and pathogenesis of HP affecting the occurrence of PD have not yet been clarified. This review elaborates the correlation and possible pathogenesis of HP on PD, and provides new ideas for the early diagnosis, treatment and prognosis of HP in the future.
文章引用：郑雨端, 阿不来提·艾则孜. 幽门螺旋杆菌感染与帕金森病关系的研究进展[J]. 临床医学进展, 2024, 14(1): 533-539. https://doi.org/10.12677/ACM.2024.141074

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