可溶性鸟苷酸环化酶–维利西呱用于心力衰竭的机制
The Mechanism of Soluble Guanylate Cyclase-Veliciguat for Heart Failure
DOI: 10.12677/ACM.2024.141086, PDF,   
作者: 王素梅:重庆医科大学第二临床学院,重庆;苏 立*:重庆医科大学附属第二医院心血管内科,重庆
关键词: 心力衰竭维利西呱作用机制Heart Failure Vericiguat Mechanism of Action
摘要: 维利西呱(Vericiguat)是第一个被批准用于治疗射血分数降低的有症状慢性心力衰竭(HFrEF)成人的口服可溶性鸟苷酸环化酶(sGC)刺激剂。心力衰竭仍然是老年人的高患病率高死亡率疾病,给卫生保健系统带来了重大的经济负担。现目前心力衰竭一线治疗包括β受体阻滞剂、血管紧张素转换酶抑制剂(ACEi)、血管紧张素受体阻滞剂(ARBs)、盐皮质激素受体拮抗剂(MRA)等。有最新研究表明可溶性鸟苷酸环化酶刺激剂维利西呱能通过修饰一氧化氮-sGC-环磷酸鸟苷(sCG)级联反应进而改善心力衰竭(或射血分数减低)患者预后。为了提高临床医生对维利西呱在心力衰竭治疗中的认识,促进维利西呱在心力衰竭治疗中的实际应用,本文就维利西呱缓解心力衰竭的机制进行综述。
Abstract: Vericiguat is the first oral soluble guanylate cyclase (sGC) stimulator approved for the treatment of adults with symptomatic chronic heart failure (HFrEF) with reduced ejection fraction. Heart failure remains a high-prevalence and mortality disease in older people, placing a significant economic burden on health care systems. At present, the first-line treatment of heart failure includes β-blockers, angiotensin-converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARBs), mineralocorticoid receptor antagonists (MRA), etc. Recent studies have shown that the soluble guanylate cyclase stimulator vericiguat can improve the prognosis of patients with heart failure (or reduced ejection fraction) by modifying the nitric oxide-sGC-cyclic guanosine monophosphate (sCG) cascade. In order to improve clinicians’ understanding of the role of vericiguat in the treatment of heart failure and promote the practical application of vericiguat in the treatment of heart failure, this article reviews the mechanism of vericiguat in the treatment of heart failure.
文章引用:王素梅, 苏立. 可溶性鸟苷酸环化酶–维利西呱用于心力衰竭的机制[J]. 临床医学进展, 2024, 14(1): 622-629. https://doi.org/10.12677/ACM.2024.141086

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