下肢深静脉血栓患者血脂的表达水平及其临床意义分析

Analysis of the Expression Levels of Lipids and Their Clinical Significance in Patients with Lower Extremity Deep Vein Thrombosis

摘要: 目的：探讨血脂水平与下肢深静脉血栓(DVT)之间潜在临床意义。方法：研究纳入204例研究对象，包括104名DVT患者和100名非DVT患者。本研究收集了两组患者的年龄、性别，体重指数(BMI)、吸烟史、现病史、既往史等基本信息，高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三酯(TG)、总胆固醇(TC)、载脂蛋白A1 (APOA1)、载脂蛋白B (APOB)等血脂指标的结果，以及活化部分凝血活酶时间(APTT)、凝血活酶时间(TT)、凝血酶原时间(PT)、纤维蛋白原(FIB)等凝血指标的结果。应用多变量回归分析，对两组研究对象进行分析。在本研究中，我们特别关注血脂水平与DVT之间的潜在联系。结果：64岁及以下的人群HDL、TG值和两年龄组的APOA1值与患DVT有关(P < 0.05)。其中，64岁及以下的人群中较高的HDL值和两年龄组较高的APOA1值是患DVT的保护因素，即该年龄段的HDL和AOPA1值越高，患DVT的可能性越小。64岁及以下人群较高的TG值是患DVT的危险因素，即TG值越高，该人群患DVT的可能性越高。结论：研究认为HDL水平降低增加了DVT发生的风险，同时APOA1值也是患DVT的保护因素，即高APOA1与DVT风险降低有关，此外TG值是患DVT的危险因素。

Abstract: Objective: To investigate the potential clinical significance of the relationship between lipid levels and lower extremity deep vein thrombosis (DVT). Methods: The study encompassed 204 partici-pants, consisting of 104 individuals diagnosed with DVT and 100 non-DVT subjects. We meticulous-ly collected and analyzed essential demographic details, including age, gender, body mass index (BMI), smoking history, current medical conditions, and medical history. Additionally, we obtained lipid profile data, encompassing high-density lipoprotein (HDL), low-density lipoprotein (LDL), tri-glycerides (TG), total cholesterol (TC), apolipoprotein A1 (APOA1), and apolipoprotein B (APOB). Furthermore, we measured coagulation parameters, including activated partial thromboplastin time (APTT), thromboplastin time (TT), prothrombin time (PT), fibrinogen (FIB), and other coagu-lation indices. We employed a robust multivariate regression analysis to scrutinize the data from the two distinct study groups. Our primary focus was on identifying potential associations between lipid levels and the incidence of DVT. Results: Levels of HDL and TG in the population aged 64 and below, and the level of APOA in both age groups are associated with the risk of DVT (P < 0.05). Among them, higher HDL values in those aged 64 years and younger and higher APOA1 values in both age groups were protective factors for DVT, meaning that the higher the HDL and AOPA1 val-ues in that age group, the less likely they were to suffering from DVT. Higher TG values in people aged 64 years and younger are a risk factor for DVT, meaning that the higher the TG value, the higher the probability of developing DVT in that group of people. Conclusion: It was concluded that lower HDL levels increased the risk of developing DVT, as well as APOA1 values were protective fac-tors for developing DVT, that is, high APOA1 was associated with a reduced risk of DVT, in addition to TG values being a risk factor for developing DVT.