IGF2BP2在非肿瘤与肿瘤中的作用的研究现状及进展
Research Status and Progress of the Role of IGF2BP2 in Non-Tumor and Neoplasm
DOI: 10.12677/ACM.2024.141113, PDF,    科研立项经费支持
作者: 许晓丽, 刘源静, 李慧玲, 宋欣玉, 董 朝*：新疆医科大学附属肿瘤医院乳腺甲状腺外科，新疆 乌鲁木齐
关键词: IGF2BP2；RNA结合蛋白；m6A阅读器；IGF2BP2； RNA-Binding Proteins； m6A Reader
摘要: IGF2BP2被认为是2型糖尿病(T2DM)相关基因，其通过对多种细胞类型中众多基因的转录后调节来调节人类代谢疾病(如糖尿病、肥胖症和脂肪肝)的细胞代谢；而作为m6A阅读器，IGF2BP2通过与不同的RNA通信，如microRNA (miRNA)、信使RNA (mRNA)和长链非编码RNA (lncRNA)参与癌症的发生和进展。我们通过综述IGF2BP2在非肿瘤与肿瘤中的作用，以望更深层次地挖掘到IGF2BP2在疾病中的作用机制。
Abstract: IGF2BP2 is considered to be a type 2 diabetes (T2DM) related gene that regulates cellular metabo-lism in human metabolic diseases such as diabetes, obesity, and fatty liver through post-transcriptional regulation of numerous genes in multiple cell types. As an m6A reader, IGF2BP2 is involved in the development and progression of cancer by communicating with different RNAs, such as microRNA (miRNA), messenger RNA (mRNA) and long non-coding RNA (lncRNA). By reviewing the role of IGF2BP2 in non-tumor and tumor, we hope to dig deeper into the mechanism of IGF2BP2 in disease.
文章引用：许晓丽, 刘源静, 李慧玲, 宋欣玉, 董朝. IGF2BP2在非肿瘤与肿瘤中的作用的研究现状及进展[J]. 临床医学进展, 2024, 14(1): 809-812. https://doi.org/10.12677/ACM.2024.141113

参考文献

[1] Nielsen, J., Christiansen, J., Lykke-Andersen, J., Johnsen, A.H., et al. (1999) A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development. Molecular and Cellular Biology, 19, 1262-1270. [Google Scholar] [CrossRef] 
[2] Dai, N. (2020) The Diverse Functions of IMP2/IGF2BP2 in Metabo-lism. Trends in Endocrinology and Metabolism, 31, 670-679.
[3] Barghash, A., Helms, V. and Kessler, S.M. (2015) Overexpression of IGF2 mRNA-Binding Protein 2 (IMP2/p62) as a Feature of Basal-Like Breast Cancer Correlates with Short Survival. Scandinavian Journal of Immunology, 82, 142-143. [Google Scholar] [CrossRef] [PubMed]
[4] Tybl, E., Shi, F.D., Kessler, S.M., et al. (2011) Overexpression of the IGF2-mRNA Binding Protein p62 in Transgenic Mice In-duces a Steatotic Phenotype. Journal of Hepatology, 54, 994-1001.
[5] Dai, N., Zhao, L., Wrighting, D., et al. (2015) IGF2BP2/IMP2 Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs En-coding Mitochondrial Proteins. Cell Metabolism, 21, 609-621. [Google Scholar] [CrossRef] [PubMed]
[6] Yang, H.I., Huang, P.Y., Chan, S.C., et al. (2022) miR-196a En-hances Polymerization of Neuronal Microfilaments through Suppressing IMP3 and Upregulating IGF2 in Huntington’s Disease. Molecular Therapy. Nucleic Acids, 30, 286-299. [Google Scholar] [CrossRef] [PubMed]
[7] Claus, C., Slavin, M., Ansseau, E., et al. (2023) The Double Homeodomain Protein DUX4c Is Associated with Regenerating Muscle Fibers and RNA-Binding Proteins. Skeletal Muscle, 13, Article No. 5. [Google Scholar] [CrossRef] [PubMed]
[8] Wang, X., Lin, J., Jiao, Z., et al. (2023) Circular RNA cir-cIGF2BP3 Promotes the Proliferation and Differentiation of Chicken Primary Myoblasts. International Journal of Mo-lecular Sciences, 24, Article 15545. [Google Scholar] [CrossRef] [PubMed]
[9] Hanahan, D. (2022) Hallmarks of Cancer: New Dimensions. Cancer Discovery, 12, 31-46.
[10] Warburg, O., Wind, F. and Negelein, E. (1927) The Metabolism of Tumors in the Body. The Journal of General Physiology, 8, 519-530.
[11] Som, P., Atkins, H.L., Bandoypadhyay, D., et al. (1980) A Fluori-nated Glucose Analog, 2-Fluoro-2-Deoxy-D-Glucose (F-18): Nontoxic Tracer for Rapid Tumor Detection. Journal of Nuclear Medicine, 21, 670-675.
[12] Cao, J., Yan, W., Ma, X., et al. (2021) Insulin-Like Growth Factor 2 mRNA-Binding Protein 2-a Potential Link between Type 2 Diabetes Mellitus and Cancer. The Journal of Clinical Endo-crinology and Metabolism, 106, 2807-2818. [Google Scholar] [CrossRef] [PubMed]
[13] Lunde, B.M., Moore, C. and Varani, G. (2007) RNA-Binding Pro-teins: Modular Design for Efficient Function. Nature Reviews Molecular Cell Biology, 8, 479-490. [Google Scholar] [CrossRef] [PubMed]
[14] Cao, J.G., Mu, Q.C. and Huang, H.Y. (2018) The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells. Stem Cells International, 2018, Article ID: 4217259.
[15] Kessler, S.M., Haybaeck, J. and Kiemer, A.K. (2016) Insulin-Like Growth Factor 2—The Oncogene and Its Accomplices. Current Pharmaceutical Design, 22, 5948-5961. [Google Scholar] [CrossRef] [PubMed]
[16] Zhou, H., Sun, Q., Feng, M., et al. (2023) Regulatory Mechanisms and Therapeutic Implications of Insulin-Like Growth Factor 2 mRNA-Binding Proteins, the Emerging Cru-cial m6A Regulators of Tumors. Theranostics, 13, 4247-4265. [Google Scholar] [CrossRef] [PubMed]
[17] Nielsen, F.C., Nielsen, J. and Christiansen, J. (2001) A Family of IGF-II mRNA Binding Proteins (IMP) Involved in RNA Trafficking. Scandinavian Journal of Clinical and Laboratory Inves-tigation, 61, 93-99.
[18] Wang, J.Y., Chen, L.J. and Qiang P., (2021) The Role of IGF2BP2, an m6A Reader Gene, in Human Metabolic Diseases and Cancers. Cancer Cell International, 21, Article No. 99.
[19] Liu, W., Li, Y., Wang, B., et al. (2015) Autoimmune Response to IGF2 mRNA-Binding Protein 2 (IMP2/p62) in Breast Cancer. Scandinavian Journal of Immunology, 81, 502-507. [Google Scholar] [CrossRef] [PubMed]
[20] Huang, S., Wu, Z., Cheng, Y., Wei, W.Z. and Hao, L.L. (2019) Insulin-Like Growth Factor 2 mRNA Binding Protein 2 Promotes Aerobic Glycolysis and Cell Proliferation in Pancreatic Ductal Adenocarcinoma via Stabilizing GLUT1 mRNA. Acta Biochimica et Biophysica Sinica, 51, 743-752. [Google Scholar] [CrossRef] [PubMed]
[21] Zhang, Z. and Zhang, H.J. (2021) Glycometabolic Rearrangements-Aerobic Glycolysis in panCreatic Ductal Adenocarcinoma (PDAC): Roles, Regulatory Networks, and Therapeutic Potential. Expert Opinion on Therapeutic Targets, 25, 1077-1093. [Google Scholar] [CrossRef] [PubMed]
[22] Pu, J., Wang, J.C., Qin, Z.B., et al. (2020) IGF2BP2 Pro-motes Liver Cancer Growth through an m6A-FEN1-Dependent Mechanism. Frontiers in Oncology, 10, Article 578816. [Google Scholar] [CrossRef] [PubMed]
[23] Liu, Y.H., Shi, M.M., He, X.F., et al. (2022) LncRNA-PACERR Induces Pro-Tumour Macrophages via Interacting with miR-671-3p and m6A-Reader IGF2BP2 in Pancreatic Ductal Adenocarcinoma. Journal of Hematology & Oncology, 15, Article No. 52. [Google Scholar] [CrossRef] [PubMed]
[24] Liu, G.H., Zhu, T.N., Cui, Y.J., et al. (2015) Correlation be-tween IGF2BP2 Gene Polymorphism and the Risk of Breast Cancer in Chinese Han Women. Biomedicine & Pharma-cotherapy, 69, 297-300.
[25] Shi, Y.Q., Xiong, X.Y., Sun, Y., et al. (2023) IGF2BP2 Promotes Ovarian Cancer Growth and Metastasis by Upregulating CKAP2L Protein Expression in an m6 A-Dependent Manner. FASEB Journal, 37, e23183. [Google Scholar] [CrossRef] 
[26] Yao, B., Zhang, Q.L., Yang, Z., et al. (2022) Cir-cEZH2/miR-133b/IGF2BP2 Aggravates Colorectal Cancer Progression via Enhancing the Stability of m6A-Modified CREB1 mRNA. Molecular Cancer, 21, Article No. 140. [Google Scholar] [CrossRef] [PubMed]
[27] Vita, M. and Henriksson, M. (2006) The Myc Oncoprotein as a Therapeutic Target for Human Cancer. Seminars in Cancer Biology, 16, 318-330. [Google Scholar] [CrossRef] [PubMed]
[28] Wu, X., Zhang, N., Li, J., et al. (2022) gga-miR-449b-5p Regulates Steroid Hormone Synthesis in Laying Hen Ovarian Granulosa Cells by Targeting the IGF2BP3 Gene. Animals, 12, Article 2710. [Google Scholar] [CrossRef] [PubMed]

为你推荐