血清维生素D水平与心血管疾病的相关性研究：基于美国NHANES 2011~2020年数据

The Study of Correlation between Serum Vitamin D Levels and Cardiovascular Disease: Based on Data from NHANES in the United States from 2011~2020

摘要: 目的：探究血清维生素D水平与成人心血管疾病(Cardiovascular diseases, CVD)间的相关性。方法：使用美国国家健康和营养调查(national health and nutrition examination survey, NHANES) 2011~2020年数据进行分析，共纳入4802名20~80岁该项接受健康调查的成年人，采用方差分析和卡方检验进行相关统计学分析，采用回归模型探讨血清维生素D水平与CVD的关系。结果：与血清维生素D正常组相比，维生素D缺乏与CVD相关(OR = 1.32; 95% CI = 1.03~1.69; P = 0.027)。维生素D不足、维生素D过量与CVD间无明显统计学意义(P > 0.05)。结论：避免过低的血清维生素D水平可能对心血管健康有潜在的好处。维生素D缺乏可能会带来更高的心血管疾病风险，其包括心力衰竭、冠心病、心绞痛和心肌梗死，而不足或过量的血清维生素D水平并不增加心血管疾病的发病风险。

Abstract: Objective: To investigate the correlation between serum vitamin D levels and adult cardiovascular diseases (CVD). Method: The data from the National Health and Nutrition Examination Survey (NHANES) in the United States from 2011 to 2020 for analysis. A total of 4802 adults aged 20 to 80 who underwent the health survey were included. Analysis of variance and chi square tests were used for correlation statistical analysis, and regression models were used to explore the relation-ship between serum vitamin D levels and CVD. Result: Compared with the normal serum vitamin D group, vitamin D deficiency was associated with CVD (OR = 1.32; 95% CI = 1.03~1.69; P = 0.027). There was no significant statistical difference among vitamin D deficiency, vitamin D excess, and CVD (P > 0.05). Conclusion: Avoiding low serum vitamin D levels may have potential benefits for cardiovascular health. Vitamin D deficiency may bring a higher risk of cardiovascular disease, in-cluding heart failure, coronary heart disease, angina pectoris, and myocardial infarction, while in-sufficient or excessive serum vitamin D levels do not increase the risk of cardiovascular disease.