非酒精性脂肪肝与射血分数保留心力衰竭相关性研究进展

Research Progress on the Correlation between Nonalcoholic Fatty Liver and Ejection Fraction Preservation Heart Failure

摘要: 心力衰竭(heart failure, HF)是各种心脏疾病发展的终末期阶段，会严重影响患者生活质量，其再住院率和死亡率不断上升，目前已成为全球公共卫生问题。在HF中，射血分数保留的心力衰竭(Heart failure with preserved ejection fraction, HFpEF)是最常见的形式，约占HF的50%。虽然HF是一种无法根治的疾病，但也能通过早期干预措施预防其发生，通过药物治疗方法改善心功能。迄今为止，HFpEF的发病机制复杂，诊断及针对性治疗仍具有挑战性，因此对HFpEF的提前干预和延缓临床进展，也是HF研究的重点。有关非酒精性脂肪肝(Non-alcoholic fatty liver disease, NAFLD)在HFpEF发生发展过程中的相关机制已成为研究热点，为了更加深入地认识两者之间的相关性，本文查阅大量相关文献，将NAFLD与HFpEF相关性研究进展进行综述，进而为临床管理和治疗提供线索依据。

Abstract: Heart Failure (HF) is the final stage of the development of various heart diseases, which can seri-ously affect the quality of life of patients, and its readmission and mortality rates are increasing, and has now become a global public health problem. In HF, Heart failure with preserved ejection frac-tion (HFpEF) is the most common form, accounting for about 50% of HF. Although HF is a disease that cannot be cured, it can also be prevented by early intervention measures and improve cardiac function through drug therapy. So far, the pathogenesis of HFpEF is complex, and the diagnosis and targeted treatment are still challenging. Therefore, the early intervention and delay of clinical pro-gress of HFpEF are also the focus of HF research. The mechanism related to the occurrence and de-velopment of Non-alcoholic fatty liver disease (NAFLD) in HFpEF has become a research hotspot. In order to have a deeper understanding of the correlation between the two, a large number of rele-vant literatures are consulted in this paper. This paper summarizes the research progress of the correlation between NAFLD and HFpEF, so as to provide clues for clinical management and treat-ment.