组织或器官纤维化中成纤维细胞EphrinB2表达的研究进展

Advances in EphrinB2 Expression in Fibroblasts in Tissue or Organ Fibrosis

摘要: 纤维化是大多数慢性炎症性疾病的病理特征，并且会损害正常组织修复反应中的多个步骤，包括炎症调节失调、血管生成、细胞基质沉积、细胞迁移、成纤维细胞激活和持续。如果不加以控制，功能性组织向非细胞纤维结缔组织转变可能导致器官衰竭。可影响包括肺、心、脑、肾和皮肤等多个器官。EphB4是最大的酪氨酸激酶受体家族中的一员，EphrinB2为其特异性配体。EphrinB2/EphB4信号通路广泛参与到全身多个组织器官系统的病理生理过程中，如神经系统的发育、胚胎心血管的发生、骨骼的重塑、肿瘤血管新生等等。近年来有关该信号通路在组织及器官纤维化中的发生发展的研究逐渐增加。本文就EphrinB2在组织或器官纤维化中尤其在成纤维细胞中的表达作简单概述。

Abstract: Fibrosis is the pathological characteristic of most chronic inflammatory diseases, and can damage the normal tissue repair responses of several steps, including inflammation, adjustment disorder, angiogenesis, cell matrix deposition, cell migration, fibroblast activation and sustained. If un-checked, the transition of functional tissue to acellular fibrous connective tissue can lead to organ failure. It can affect multiple organs including lungs, heart, brain, kidneys and skin. EphB4 is a member of the largest family of tyrosine kinase receptors, and EphrinB2 is its specific ligand. EphrinB2/EphB4 signaling pathway is widely involved in the whole body of multiple tissues and organs system pathophysiological process, such as the development of the nervous system, the oc-currence of cardiovascular, skeletal plastic, tumor angiogenesis and so on. In recent years, studies on the role of this signaling pathway in the occurrence and development of tissue and organ fibrosis have gradually increased. In this paper, the EphrinB2 especially in tissue or organ fibrosis expres-sion in fibroblasts were briefly overview.