冠心病合并OSAHS患者CACS与AHI、LaSO₂的相关性分析

Correlation Analysis of CACS and AHI, LaSO₂ in Patients with Coronary Heart Disease and OSAHS

摘要: 目的：探讨冠心病合并OSAHS患者的CACS与AHI、LaSO₂之间的相关性。方法：回顾性收集2022年04月~2023年02月在青岛大学附属医院行PSG + CCTA的病例共114例。根据CCTA测得的CACS积分的情况，将患者分为无心血管病风险组：CACS = 0分(n = 49例)，有心血管病风险组：CACS > 0分(n = 65例)。比较两组间相关指标的差异性，并明确CACS与AHI、LaSO₂之间的相关及回归关系。结果：与无心血管风险组相比，有心血管风险组年龄、AHI更高，LaSO₂更低，差异有统计学意义(p < 0.05)。CACS总值与AHI呈显著的正相关(rs = 0.442, p < 0.001)，与LaSO2呈显著的负相关(r_s = −0.378, p < 0.001)。一元线性回归分析示：AHI、LaSO₂是CACS的主要危险因素(B值分别为7.352，−5.936，β值分别为0.283、−0.133，p值分别为0.002、0.038)。在控制协变量后，AHI、LaSO2对CACS的效应仍显著(B值分别为9.653，−7.674，β值分别为0.371、−0.172，p值分别为0.014、0.045)，可作为CSCS的独立预测因子。结论：阻塞性睡眠呼吸暂停严重程度与CACS严重程度呈正相关，且AHI与CACS呈正相关，LaSO₂与CACS呈负相关，AHI、LaSO₂可被视为冠状动脉疾病高风险的独立预测因子(基于CACS)。

Abstract: Purpose: To investigate the correlation between CACS and AHI, LaSO₂ in patients with CHD com-bined with OSAHS. Methods: This study was a retrospective case analysis. 114 patients who under-went PSG + CCTA in the Affiliated Hospital of Qingdao University from April 2022 to April 2023 were collected. According to the CACS measured by CCTA, the patients were divided into two groups: the group without cardiovascular risk: CACS = 0 (n = 49 cases), and the group with cardiovascular risk: CACS > 0 (n = 65 cases). The differences of relevant indexes in different groups were compared. And the correlation and regression relationship between CACS and AHI, LaSO₂ were clarified. Results: Compared with the group without cardiovascular risk, the group with cardiovascular risk had high-er age, AHI and lower LaSO₂, and the difference was statistically significant (p < 0.05). The CACS was significantly positively correlated with AHI (rs = 0.442, p < 0.001) and negatively correlated with LaSO₂ (rs = −0.378, p < 0.001). Unary linear regression analysis showed that AHI and LaSO₂ were the main risk factors of CACS (B = 7.352, −5.936, β = 0.283, −0.133, p = 0.002, 0.038). After controlling for covariables, AHI and LaSO₂ still had significant effects on CACS (B = 9.653, −7.674, β = 0.371, −0.172, p = 0.014, 0.045), and were independent risk factors for CACS. Conclusions: The severity of OSAHS was positively correlated with the severity of CACS. AHI was positively correlated with CACS and LaSO₂ was negatively correlated with CACS, which could be considered as independent predic-tors of high risk of coronary artery disease (based on CACS).