炎症环境在胃恶性肿瘤的预后分析
Prognostic Analysis of Inflammatory Environment in Gastric Malignancies
DOI: 10.12677/ACM.2024.141193, PDF,   
作者: 沙娜提·努尔兰, 许新才*：新疆医科大学第一附属医院胃肠(肿瘤)外科，新疆 乌鲁木齐
关键词: 胃恶性肿瘤；炎症；肿瘤相关巨噬细胞；预后营养；Gastric Malignancy； Inflammation； Tumor-Associated Macrophages； Prognostic Nutrition
摘要: 近年，国内外学者对胃恶性肿瘤的预后因素进行了广泛研究，其中以非特异性炎症免疫标志物在胃恶性肿瘤中的研究较为集中。对可切除性胃恶性肿瘤患者来说，肿瘤相关巨噬细胞和肿瘤浸润淋巴细胞是研究的热点。此外，统性免疫炎症指数、预后营养指数，这些炎症和免疫指标对行可切除性胃恶性肿瘤手术患者的预后也具有指导意义，本文就胃恶性肿瘤预后指标进行分析，期望为相关研究提供参考。
Abstract: In recent years, domestic and foreign scholars have extensively studied the prognostic factors of gastric malignant tumors, among which the non-specific inflammatory immune markers in gastric malignant tumors are more concentrated. For patients with resectable gastric malignancies, tu-mor-associated macrophages and tumor-infiltrating lymphocytes are the focus of research. In addi-tion, the universal immunoinflammatory index and prognostic nutritional index, which are inflam-matory and immune indicators, also have guiding significance for the prognosis of patients under-going surgery for resectable gastric malignant tumors. This paper analyzes the prognostic indica-tors of gastric malignant tumors, hoping to provide reference for related studies.
文章引用：沙娜提·努尔兰, 许新才. 炎症环境在胃恶性肿瘤的预后分析[J]. 临床医学进展, 2024, 14(1): 1336-1342. https://doi.org/10.12677/ACM.2024.141193

参考文献

[1] Wu, C.C., et al. (2019) Analysis of Status and Countermeasures of Cancer Incidence and Mortality in China. Science China Life Sciences, 62, 640-647. [Google Scholar] [CrossRef] [PubMed]
[2] Cao, W., et al. (2021) Changing Profiles of Cancer Burden Worldwide and in China: A Secondary Analysis of the Global Cancer Statistics 2020. Chinese Medical Journal (England), 134, 783-791. [Google Scholar] [CrossRef] 
[3] Johnston, F.M. and Beckman, M. (2020) Updates on Man-agement of Gastric Cancer. Current Oncology Reports, 21, 67. [Google Scholar] [CrossRef] [PubMed]
[4] 陈智良, 费素娟, 郭雅慧, 等. 术前血清白蛋白碱性磷酸酶比值在胃癌预后评估中的价值[J]. 安徽医药, 2022, 26(8): 1570-1575.
[5] 徐慧, 秦静静, 张曹, 等. 血浆D-二聚体水平与胃癌患者预后关系Meta分析[J]. 陕西医学杂志, 2022, 51(9): 1158-1162.
[6] 李吴寒, 张营, 潘晶晶, 等. 胃癌患者预后相关影响因素的列线图模型构建及验证[J]. 中国普通外科杂志, 2022, 31(10): 1381-1388.
[7] 殷坤, 权昕, 李杰, 等. 肿瘤相关性炎症在消化道肿瘤中的作用及机制研究进展[J]. 现代肿瘤医学, 2023, 31(19): 3684-3688.
[8] 郭秋均, 李杰. 肿瘤相关巨噬细胞在重塑肿瘤免疫微环境中的作用[J]. 肿瘤, 2013, 33(10): 922-927.
[9] 何楠, 金倩娜, 王笛, 等. 肿瘤相关巨噬细胞对胃癌细胞侵袭转移的影响[J]. 中华胃肠外科杂志, 2016, 19(7): 793-797. [Google Scholar] [CrossRef] 
[10] 苏鹏飞. 肿瘤相关巨噬细胞与胃癌细胞的交互作用及其对胃癌耐药和新辅助化疗预后影响的研究[D]: [博士学位论文]. 北京: 北京协和医学院, 2023.[CrossRef] 
[11] 林强. 肿瘤相关巨噬细胞在胃癌局部免疫状态中的作用及其与预后的关系[D]: [硕士学位论文]. 桂林: 桂林医学院, 2019.
[12] Wu, X., Jiang, Y., Ge, H., et al. (2020) Predictive Value of Prognostic Nutritional Index in Patients with Oral Squamous Cell Carcinoma. Oral Diseases, 26, 903-911. [Google Scholar] [CrossRef] [PubMed]
[13] Hu, Z., Li, W., Chen, S., et al. (2023) Design of a Novel Chimeric Peptide via Dual Blockade of CD47/SIRPα and PD-1/PD-L1 for Cancer Immunotherapy. Science China Life Sciences, 66, 2310-2328. [Google Scholar] [CrossRef] [PubMed]
[14] 陈怡, 朱艳丽, 李云凤, 等. 胃癌化疗及靶向治疗药物的研究进展[J]. 广东化工, 2023, 50(13): 92-93+106.
[15] 罗泽宇. 术前预后营养指数对进展期胃癌术后预后的影响[D]: [博士学位论文]. 广州: 南方医科大学, 2020.[CrossRef] 
[16] Yoo, Y.J., Kang, C.M., Choi, M., et al. (2020) Preopera-tive Prognostic Nutritional Index as an Independent Prognostic Factor for Resected Ampulla of Vater Cancer. PLOS ONE, 15, e0229597. [Google Scholar] [CrossRef] [PubMed]
[17] Karsiyakali, N., Karabay, E. and Yucetas, U. (2020) Predictive Value of Prognostic Nutritional Index on Tumor Stage in Patients with Primary Bladder Cancer. Archivos Espaoles de Urología, 73, 132-139.
[18] Migita, K., Takayama, T., Saeki, K., et al. (2013) The Prognostic Nutritional Index Predicts Long-Term Outcomes of Gastric Cancer Patients Independent of Tumor Stage. Annals of Surgical Oncology, 20, 2647-2654. [Google Scholar] [CrossRef] [PubMed]
[19] Cassetta, L. and Pollard, J.W. (2018) Targeting Macrophages: Therapeutic Approaches in Cancer. Nature Reviews Drug Discovery, 17, 887-904. [Google Scholar] [CrossRef] [PubMed]
[20] 郭梁, 刘海鹏, 陈康, 等. 外周血NLR和PLR对胃癌预后评估的研究进展[J]. 医学综述, 2021, 27(4): 702-706. [Google Scholar] [CrossRef] 
[21] 刘佳君, 田建辉, 阙祖俊. 中性粒细胞促进循环肿瘤细胞转移的作用及机制[J]. 中国肿瘤生物治疗杂志, 2023, 30(11): 992-996.
[22] Alar, R. (2023) The Relation-ship of Different Preoperative Inflammatory Markers with the Prognosis of Gastric Carcinoma. Asian Journal of Surgery, 46, 360-365. [Google Scholar] [CrossRef] [PubMed]
[23] 胡希阳, 骆玉霜, 徐新倩. NLR/LMR/PLR与胃癌患者预后的相关研究[J]. 临床医学进展, 2022, 12(5): 4240-4245. [Google Scholar] [CrossRef] 
[24] 张慧, 殷红, 胡广越. 术前CRP/ALB, GPS与炎症相关指标在胃癌预后中的价值[J]. 中国继续医学教育, 2021, 13(35): 125-129.
[25] 曹策, 韩承新, 蔡晓军, 等. 中性粒细胞与淋巴细胞比例与胃癌转移淋巴结坏死的关系[J]. 武警医学, 2013, 24(1): 33-36. [Google Scholar] [CrossRef] 
[26] Chen, J., Hong, D., Zhai, Y., et al. (2015) Meta-Analysis of Associations between Neutrophil-to-Lymphocyte Ratio and Prognosis of Gastric Cancer. World Journal of Surgical Oncology, 13, 122. [Google Scholar] [CrossRef] [PubMed]
[27] Zhang, R., Li, F., Li, H., et al. (2013) The Clinical Significance of Memory T Cells and Its Subsets in Gastric Cancer. Clinical and Translational Oncology, 16, 257-265. [Google Scholar] [CrossRef] [PubMed]
[28] 倪娜, 潘雪君, 赵霞, 等. 肿瘤浸润淋巴细胞免疫治疗的临床研究进展[J]. 世界临床药物, 2023, 44(2): 105-112. [Google Scholar] [CrossRef] 
[29] 韩明伟, 李一鸣, 蒋建利. 肿瘤微环境中CD8+ T细胞分化与免疫治疗的研究进展[J]. 细胞与分子免疫学杂志, 2022, 38(8): 760-766. [Google Scholar] [CrossRef] 
[30] 李田田, 李琳, 廖力微. CD4+ CAR-T细胞亚群在肿瘤治疗中作用的研究进展[J]. 中国肿瘤生物治疗杂志, 2023, 30(3): 255-260.
[31] 冯茜莉, 王慧慧, 汪梦竹, 等. 自然杀伤细胞在抗感染和肿瘤治疗中的作用[J]. 细胞与分子免疫学杂志, 2023, 39(10): 952-958. [Google Scholar] [CrossRef] 
[32] 徐雪莹, 章燕, 叶开, 等. 基于脂质代谢基因构建胃癌预后预测模型[J]. 牡丹江医学院学报, 2023, 44(4): 29-34.
[33] Hirahara, N., Tajima, Y., Fujii, Y., et al. (2020) High Preoperative Prognostic Nutritional Index Is Associated with Less Postoperative Complication-Related Impairment of Long-Term Survival after Laparoscopic Gastrectomy for Gastric Cancer. Journal of Gastrointestinal Surgery, 24, 2852-2855. [Google Scholar] [CrossRef] [PubMed]
[34] Sugawara, K., Aikou, S., Yajima, S., et al. (2020) Pre- and Post-Operative Low Prognostic Nutritional Index Influences Survival in Older Patients with Gastric Carcinoma. Journal of Geriatric Oncology, 11, 989-996. [Google Scholar] [CrossRef] [PubMed]
[35] Zhu, X.S., Zhao, Y., Ma, F.Y., et al. (2020) The Role of Prognostic Nutritional Index for Clinical Outcomes of Gastric Cancer after Total Gastrectomy. Scientific Reports, 10, Article No. 17373. [Google Scholar] [CrossRef] [PubMed]
[36] Wu, T., Li, Y., Lu, J., et al. (2013) Increased MMP-21 Expression Is Associated with Poor Overall Survival of Patients with Gastric Cancer. Medical Oncology, 30, Article No. 323. [Google Scholar] [CrossRef] [PubMed]
[37] Okadome, K., Baba, Y., Yagi, T., et al. (2020) Prognostic Nutritional Index, Tumor-Infiltrating Lymphocytes, and Prognosis in Patients with Esophageal Cancer. Annals of Surgery, 271, 693-700. [Google Scholar] [CrossRef] 
[38] Yang, Y., Gao, P., Song, Y., et al. (2016) The Prognostic Nutritional Index Is a Predictive Indicator of Prognosis and Postoperative Complications in Gastric Cancer: A Me-ta-Analysis. European Journal of Surgical Oncology, 42, 1176-1182. [Google Scholar] [CrossRef] [PubMed]
[39] Yan, L., Nakamura, T., Casadei-Gardini, A., et al. (2021) Long-Term and Short-Term Prognostic Value of the Prognostic Nutritional Index in Cancer: A Narrative Review. Annals of Translational Medicine, 9, 1630. [Google Scholar] [CrossRef] [PubMed]
[40] Sasahara, M., Kanda, M., Ito, S., et al. (2020) The Preoperative Prog-nostic Nutritional Index Predicts Short-Term and Long-Term Outcomes of Patients with Stage II/III Gastric Cancer: Analysis of a Multi-Institution Dataset. Digestive Surgery, 37, 135-144. [Google Scholar] [CrossRef] [PubMed]
[41] Pansy, K., Uhl, B., Krstic, J., et al. (2021) Immune Regulatory Processes of the Tumor Microenvironment under Malignant Conditions. International Journal of Molecular Sciences, 22, 13311. [Google Scholar] [CrossRef] [PubMed]

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