中医药调控细胞自噬抗肝纤维化的研究进展

Research Progress of Chinese Medicine Regulating Autophagy against Liver Fibrosis

摘要: 肝纤维化是机体对各种因素诱导的慢性病肝损伤进行的修复愈合反应，与肝硬化、肝癌的发生存在一定关系，阻止或逆转肝纤维化对于减少肝硬化和肝癌的发生至关重要。在中医学中，这一过程常被归类为“臌胀”和“积聚”等病证，往往涉及到“虚损生积”的病理机制。自噬是细胞生长、存活及自我平衡的重要过程。自噬的失调参与多种疾病的发生、发展。研究表明，细胞自噬与肝纤维化的发生、发展、转归过程有相关性，因此通过对细胞自噬进行调控可能为逆转肝纤维化提供了新的治疗策略。数十年的研究证明，中医药治疗肝纤维化疗效确切，其作用机制与细胞自噬及其相关因子或通路密切相关。该文通过总结和归纳近年来中医药通过干预细胞自噬过程，进而对肝纤维化发挥治疗作用进行综述，为中医药应用于肝纤维化进程方面提供思路和借鉴。

Abstract: Liver fibrosis is the body’s recovery and healing response to chronic liver damage caused by a vari-ety of factors, and it is also the early stage of cirrhosis. At the same time, it has a certain relationship with the occurrence of liver cancer. Preventing or reversing liver fibrosis is the key. In Chinese medicine, there are several classifications: such as “expansion” and “accumulation”, and the patho-genesis is mostly “virtual loss and accumulation”. Autophagy is an important process of cell growth, survival and homeostasis. The disorder of autophagy is involved in the occurrence and development of many diseases. Studies have shown that autophagy is related to the occurrence, development and outcome of liver fibrosis, so the regulation of autophagy may provide a new therapeutic strategy for reversing liver fibrosis. Decades of research have proved that Chinese medicine is effective in treat-ing liver fibrosis, and its mechanism of action is closely related to autophagy and its related factors or pathways. This article summarizes the therapeutic effects of traditional Chinese medicine on liv-er fibrosis through the intervention of autophagy in recent years, and provides ideas and references for the use of medicinal plants in hepatic fibrosis.