器官移植后糖尿病研究进展
Research Progress of Diabetes after Organ Transplantation
DOI: 10.12677/ACM.2024.141261, PDF,   
作者: 董 芳, 毛 军*：同济大学附属东方医院胶州医院内分泌科，山东 青岛
关键词: 移植后糖尿病；危险因素；并发症；治疗；Diabetes after Transplantation； Risk Factors； Complications； Treatment
摘要: 移植后糖尿病(PTDM)是器官移植后的常见并发症，是移植受者生活质量下降、死亡率增加的主要原因。目前对于移植后糖尿病的研究日趋增多，本文将从引起器官移植后糖尿病的危险因素、并发症及治疗三个方面就最新研究成果进行概述。
Abstract: Post-transplant diabetes mellitus (PTDM) is a common complication after organ transplantation. It is the main reason for the decreased quality of life and shorter survival time of transplant recipi-ents. There are a growing number of studies on post-transplant diabetes. This article will summa-rize the latest research results from three aspects: risk factors, complications and treatment of dia-betes after organ transplantation.
文章引用：董芳, 毛军. 器官移植后糖尿病研究进展[J]. 临床医学进展, 2024, 14(1): 1836-1840. https://doi.org/10.12677/ACM.2024.141261

参考文献

[1] Goldmannova, D., Karasek, D., Krystynik, O., et al. (2016) New-Onset Diabetes Mellitus after Renal Transplantation. Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic, 160, 195-200. [Google Scholar] [CrossRef] [PubMed]
[2] Chen, J., Li, L., An, Y., et al. (2018) Multiple Genetic Variants Associ-ated with Posttransplantation Diabetes Mellitus in Chinese Han Populations. Journal of Clinical Laboratory Analysis, 32, e22308. [Google Scholar] [CrossRef] [PubMed]
[3] Dabrowska-Zamojcin, E., Romanowski, M., Dziedziejko, V., et al. (2016) CCL2 Gene Polymorphism Is Associated with Post-Transplant Diabetes Mellitus. International Immunophar-macology, 32, 62-65. [Google Scholar] [CrossRef] [PubMed]
[4] Cen, C., Fang, H.X., Yu, S.F., et al. (2017) Association between ADIPOQ Gene Polymorphisms and the Risk of New-Onset Diabetes Mellitus after Liver Transplantation. Hepatobiliary & Pancreatic Diseases International, 16, 602-609. [Google Scholar] [CrossRef] 
[5] Zhang, X., Men, T., Liu, H., et al. (2018) Genetic Risk Factors for Post-Transplantation Diabetes Mellitus in Chinese Han Renal Allograft Recipients Treated with Tacrolimus. Transplant Immunology, 49, 39-42. [Google Scholar] [CrossRef] [PubMed]
[6] Wissing, K.M., Abramowicz, D., Weekers, L., et al. (2018) Pro-spective Randomized Study of Conversion from Tacrolimus to Cyclosporine A to Improve Glucose Metabolism in Pa-tients with Posttransplant Diabetes Mellitus after Renal Transplantation. American Journal of Transplantation, 18, 1726-1734. [Google Scholar] [CrossRef] [PubMed]
[7] Yagi, S., Kaido, T., Iida, T., et al. (2017) New-Onset Diabetes Mellitus after Living-Donor Liver Transplantation: Association with Graft Synthetic Function. Surgery Today, 47, 733-742. [Google Scholar] [CrossRef] [PubMed]
[8] Liang, J., Lv, C., Chen, M., et al. (2019) Effects of Pre-operative Hepatitis B Virus Infection, Hepatitis C Virus Infection, and Coinfection on the Development of New-Onset Diabetes after Kidney Transplantation. Journal of Diabetes, 11, 370-378. [Google Scholar] [CrossRef] [PubMed]
[9] Huang, J.W., Famure, O., Li, Y., et al. (2016) Hypomagnesemia and the Risk of New-Onset Diabetes Mellitus after Kidney Transplantation. Journal of the American Society of Nephrol-ogy, 27, 1793-1800. [Google Scholar] [CrossRef] 
[10] Garg, N., Weinberg, J., Ghai, S., et al. (2014) Lower Magnesium Level Associated with New-Onset Diabetes and Pre-Diabetes after Kidney Transplantation. Journal of Nephrology, 27, 339-344. [Google Scholar] [CrossRef] [PubMed]
[11] Yu, H., Kim, H., Baek, C.H., et al. (2016) Risk Factors for New-Onset Diabetes Mellitus after Living Donor Kidney Transplantation in Korea—A Retrospective Single Center Study. BMC Nephrology, 17, Article No. 106. [Google Scholar] [CrossRef] [PubMed]
[12] Le Fur, A., Fournier, M.C., Gillaizeau, F., et al. (2016) Vitamin D Deficiency Is an Independent Risk Factor for PTDM after Kidney Transplantation. Transplant International, 29, 207-215. [Google Scholar] [CrossRef] [PubMed]
[13] Dedinska, I., Laca, L., Miklusica, J., et al. (2018) The Role of Pro-teinuria, Paricalcitol and Vitamin D in the Development of Post-Transplant Diabetes Mellitus. Bratislava Medical Jour-nal, 119, 401-407. [Google Scholar] [CrossRef] 
[14] Xue, M., Zhao, C., Lv, C., et al. (2018) Interleukin-2 Receptor An-tagonists: Protective Factors against New-Onset Diabetes after Renal Transplantation. Journal of Diabetes, 10, 857-865. [Google Scholar] [CrossRef] [PubMed]
[15] 何顺梅, 张尧, 陈显英, 等. 白细胞介素2受体拮抗剂对器官移植受体糖代谢的影响[J]. 中华内分泌代谢杂志, 2013, 29(6): 540-543.
[16] Sharif, A. and Baboolal, K. (2011) Com-plications Associated with New-Onset Diabetes after Kidney Transplantation. Nature Reviews Nephrology, 8, 34-42. [Google Scholar] [CrossRef] [PubMed]
[17] Nadav, M., Marius, B., Tuvia, B.G., et al. (2020) Post-Transplant Diabetes Mellitus: Incidence, Predicting Factors and Outcomes. Endocrine, 69, 303-309. [Google Scholar] [CrossRef] [PubMed]
[18] Borda, B., Lazar, G., Kormanyos, A., et al. (2019) New-Onset Diabetes Mellitus Following Successful Kidney Transplantation Facilitates Aortic Stiffening. Transplantation Proceed-ings, 51, 1239-1243. [Google Scholar] [CrossRef] [PubMed]
[19] Xu, Y., Liang, J.X., Liu, B., et al. (2011) Prevalence and Long-Term Glucose Metabolism Evolution of Post-Transplant Diabetes Mellitus in Chinese Renal Recipients. Diabetes Research and Clinical Practice, 92, 11-18. [Google Scholar] [CrossRef] [PubMed]
[20] American Diabetes Association (2012) Diagnosis and Classifi-cation of Diabetes Mellitus. Diabetes Care, 35, 64-71. [Google Scholar] [CrossRef] [PubMed]
[21] Londero, T.M., Giaretta, L.S., Farenzena, L.P., et al. (2019) Microvascular Complications of Posttransplant Diabetes Mellitus in Kidney Transplant Recipients: A Longitudinal Study. The Journal of Clinical Endocrinology and Metabolism, 104, 557-567. [Google Scholar] [CrossRef] [PubMed]
[22] Fiorina, P., Lv, C., Chen, M., et al. (2014) Influencing Factors of New-Onset Diabetes after a Renal Transplant and Their Effects on Complications and Survival Rate. PLOS ONE, 9, e99406. [Google Scholar] [CrossRef] [PubMed]
[23] Siraj, E.S., Abacan, C., Chinnappa, P., et al. (2010) Risk Fac-tors and Outcomes Associated with Posttransplant Diabetes Mellitus in Kidney Transplant Recipients. Transplantation Proceedings, 42, 1685-1689. [Google Scholar] [CrossRef] [PubMed]
[24] Thangavelu, T., Lyden, E. and Shivaswamy, V. (2020) A Retrospective Study of Glucagon-Like Peptide 1 Receptor Agonists for the Management of Diabetes after Transplanta-tion. Diabetes Therapy, 11, 987-994. [Google Scholar] [CrossRef] [PubMed]
[25] Singh, P., Pesavento, T.E., Washburn, K., et al. (2018) Largest Single-Centre Experience of Dulaglutide for Management of Diabetes Mellitus in Solid Organ Transplant Recipients. Diabetes, Obesity and Metabolism, 21, 1061-1065. [Google Scholar] [CrossRef] [PubMed]
[26] Joo, K.W., Kim, S., Ahn, S.Y., et al. (2013) Dipeptidyl Peptidase IV In-hibitor Attenuates Kidney Injury in Rat Remnant Kidney. BMC Nephrology, 14, Article No. 98. [Google Scholar] [CrossRef] [PubMed]
[27] Mahling, M., Schork, A., Nadalin, S., et al. (2019) Sodium-Glucose Cotransporter 2 (SGLT2) Inhibition in Kidney Transplant Recipients with Diabetes Mellitus. Kidney & Blood Pressure Research, 44, 984-992. [Google Scholar] [CrossRef] [PubMed]
[28] Galindo, R.J., Fried, M., Breen, T., et al. (2016) Hyperglycemia Manage-ment in Patients with Posttransplantation Diabetes. Endocrine Practice, 22, 454-465. [Google Scholar] [CrossRef] 
[29] Hecking, M., Haidinger, M., Doller, D., et al. (2012) Early Basal Insu-lin Therapy Decreases New-Onset Diabetes after Renal Transplantation. Journal of the American Society of Nephrology, 23, 739-749. [Google Scholar] [CrossRef] 

为你推荐