视网膜母细胞瘤铂类耐药机制及耐药治疗的研究进展
Research Progress on Platinum Resistance Mechanism and Resistance Therapy in Retinoblastoma
DOI: 10.12677/ACM.2024.141266, PDF,    科研立项经费支持
作者: 罗应洁:大理大学临床医学院,云南 大理;李才锐*:大理州人民医院眼科,云南 大理;孙曙光*:大理大学第一附属医院内分泌科,云南 大理
关键词: 视网膜母细胞瘤铂类耐药性治疗Retinoblastoma Platinum Drug Resistance Treat
摘要: 视网膜母细胞瘤是一种最常见于儿童的原发性眼内恶性肿瘤,其恶性程度高、病程进展快,预后差。近年来,铂类化疗药物被发现对晚期和转移性视网膜母细胞瘤具有显著的治疗效果。然而,随着临床研究的不断深入,铂类药物治疗晚期视网膜母细胞瘤的耐药问题逐渐浮出水面。本文旨在综述近年来铂类对视网膜母细胞瘤的耐药机制和耐药后治疗的研究进展。旨在为后续研究提供参考。
Abstract: Retinoblastoma is one of the most common primary intraocular malignant tumors in children. It has high malignancy, rapid progression and poor prognosis. In recent years, platinum based chem-otherapy drugs have been found to have significant therapeutic effects on advanced and metastatic retinoblastoma. However, with the deepening of clinical research, the resistance of platinum drugs in the treatment of advanced retinoblastoma gradually surfaced. This article aims to review the mechanism of platinum resistance to retinoblastoma and the research progress of post resistance treatment in recent years. It aims to provide references for subsequent research.
文章引用:罗应洁, 李才锐, 孙曙光. 视网膜母细胞瘤铂类耐药机制及耐药治疗的研究进展[J]. 临床医学进展, 2024, 14(1): 1877-1887. https://doi.org/10.12677/ACM.2024.141266

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