探讨肝素结合蛋白、乳酸脱氢酶与肺炎支原体肺炎患儿病情严重程度的相关性

The Correlation between Heparin Binding Protein, Lactate Dehydrogenase and the Severity of Mycoplasma pneumoniae Pneumonia in Children

摘要: 目的：探讨肝素结合蛋白(Heparin binding protein, HBP)、乳酸脱氢酶(LDH)与肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia, MPP)患儿病情严重程度的相关性。方法：选取101例轻症组患儿和31例重症组患儿，同期选取正常体检或切除包皮患儿30例作为对照组，于入院第1天检测外周血中HBP、LDH、C反应蛋白(C-reactive protein, CRP)及白细胞(WBC)的含量，对比各组HBP、LDH、CRP及WBC水平，采用接收者操作特征曲线(ROC)分析上述各临床指标对重症肺炎支原体肺炎(Severe Mycoplasma pneumoniae pneumonia, SMPP)的诊断价值。结果：重症组及轻症组的HBP、LDH及CRP均明显高于对照组(P < 0.05)，重症组的HBP、LDH及CRP水平对比轻症组有明显升高(P < 0.05)。二元logistic回归分析结果显示HBP、LDH及CRP为SMPP的独立危险因素。结论：血清HBP、LDH、CRP水平与MPP患儿病情严重程度有密切相关性，可作为重症肺炎支原体肺炎(SMPP)发生的早期预测指标。

Abstract: Objective: To explore the correlation between heparin binding protein (HBP), lactate dehydrogen-ase (LDH) and the severity of Mycoplasma pneumoniae pneumonia (MPP) in children. Method: 101 children in the mild illness group and 31 children in the severe illness group were selected accord-ing to the severity of the condition. During the same period, 30 children who underwent normal physical examination or daytime surgery (circumcision) were selected as the control group. On the first day of admission, the levels of HBP, LDH, CRP and WBC in peripheral blood were measured, and the levels of HBP, LDH, CRP and WBC in each group were compared. The diagnostic value of the above clinical indicators for severe Mycoplasma pneumoniae pneumonia (SMPP) was analyzed using receiver operating characteristic curve (ROC) analysis. Result: The levels of CRP, LDH, and HBP in the severe and mild groups were significantly higher than those in the control group (P < 0.05). The levels of CRP, LDH, and HBP in the severe group were significantly higher than those in the mild group (P < 0.05). The results of binary logistic regression analysis showed that HBP, CRP, and LDH were independent risk factors for SMPP. Conclusion: The levels of serum HBP, LDH, and CRP are closely related to the severity of MPP in children, and can be used as early predictive indicators for the occurrence of severe Mycoplasma pneumoniae pneumonia (SMPP).