射频消融治疗巨大肝血管瘤的并发症相关研究进展
Research Progress on the Complications of Radiofrequency Ablation in the Treatment of Giant Hepatic Hemangiomas
DOI: 10.12677/ACM.2024.141287, PDF,   
作者: 褚鸿钰:新疆医科大学第一附属医院,肝脏?腹腔镜外科,新疆 乌鲁木齐
关键词: 射频消融术巨大肝血管瘤并发症Radiofrequency Ablation Giant Hepatic Hemangioma Complication
摘要: 巨大肝血管瘤作为一类临床上比较少见的肝血管瘤,因为其可以发生在肝组织内任何位置,可能发生在深层位置和复杂血供,肝切除术曾经是扩大症状性肝血管瘤的首选治疗方法。虽然手术切除可以完全切除肿瘤,但手术需要重大的腹部手术,住院时间相对较长和较高的发病率和死亡率。射频消融术因其精准微创的优势,逐渐应用于肝巨大血管瘤的手术治疗中,但现阶段对于巨大肝血管瘤的射频治疗是否合适并未明确,巨大肝血管瘤首选手术治疗,无法耐受手术或手术有难度风险较高时可用分次射频消融替代。射频消融术术中仍然会有相关并发症,笔者通过统计各类并发症的发生率,有利于未来在术后治疗肝巨大血管瘤中对并发症进行临床预防。
Abstract: As a type of hepatic hemangioma that is relatively rare in clinical practice, hepatic hemangioma used to be the preferred treatment for enlarged symptomatic hepatic hemangioma because it can occur anywhere in the liver tissue, may occur in deep locations and complex blood supply. Although surgical excision can completely remove the tumor, surgery requires major abdominal surgery, a relatively long hospital stay, and high morbidity and mortality. Radiofrequency ablation is gradual-ly applied to the surgical treatment of hepatic hemangioma due to its precise and minimally inva-sive advantages, but it is not clear whether the radiofrequency treatment for hepatic hemangioma is suitable at this stage. There are still related complications during radiofrequency ablation, and the incidence of various complications is helpful for the clinical prevention of complications in the postoperative treatment of hepatic giant hemangioma in the future.
文章引用:褚鸿钰. 射频消融治疗巨大肝血管瘤的并发症相关研究进展[J]. 临床医学进展, 2024, 14(1): 2041-2047. https://doi.org/10.12677/ACM.2024.141287

参考文献

[1] Hoekstra, L.T., Bieze, M., Erdogan, D., et al. (2013) Management of Giant Liver Hemangiomas: An Update. Expert Re-view of Gastroenterology & Hepatology, 7, 263-268. [Google Scholar] [CrossRef] [PubMed]
[2] Yoon, S.S., Charny, C.K., Fong, Y., et al. (2003) Diagnosis, Management, and Outcomes of 115 Patients with Hepatic Hemangioma. Journal of the American College of Surgeons, 197, 392-402. [Google Scholar] [CrossRef
[3] 高君, 丁雪梅, 柯山, 等. 射频消融治疗巨大肝海绵状血管瘤的初步经验[J]. 中华外科杂志, 2011, 49(7): 659-661.
[4] 丁雪梅, 高君, 孙文兵. 巨大肝血管瘤射频消融治疗的并发症[J]. 中国医刊, 2015, 50(11): 15-17. [Google Scholar] [CrossRef
[5] 陈敬龙, 王彦哲, 叶松昀, 等. 射频消融治疗巨大肝血管瘤42例临床观察[J]. 中国医刊, 2016, 51(7): 90-93. [Google Scholar] [CrossRef
[6] 朱广勇, 马长林, 李一春, 等. 射频消融治疗肝巨大血管瘤69例临床疗效分析[J]. 井冈山大学学报(自然科学版), 2016, 37(5): 104-106. [Google Scholar] [CrossRef
[7] Gao, J., Kong, J., Ding, X.M., et al. (2015) Laparo-scopic vs Computerized Tomography-Guided Radiofrequency Ablation for Large Hepatic Hemangiomas Abutting the Diaphragm. World Journal of Gastroenterology, 21, 5941-5949. [Google Scholar] [CrossRef] [PubMed]
[8] Gao, J., Fan, R.-F., Yang, J.-Y., et al. (2017) Radiofrequency Abla-tion for Hepatic Hemangiomas: A Consensus from a Chinese Panel of Experts. World Journal of Gastroenterology, 23, 7077-7086. [Google Scholar] [CrossRef] [PubMed]
[9] Gao, J., Ke, S., Ding, X.M., et al. (2013) Radiofrequency Ablation for Large Hepatic Hemangiomas: Initial Experience and Lessons. Surgery, 153, 78-85. [Google Scholar] [CrossRef] [PubMed]
[10] Park, S.Y., Tak, W.Y., Jung, M.K., et al. (2011) Symptomat-ic-Enlarging Hepatic Hemangiomas Are Effectively Treated by Percutaneous Ultsonography Guided Radiofrequency Ablation. Journal of Hepatology, 54, 559-565. [Google Scholar] [CrossRef] [PubMed]
[11] 孔健, 高君, 王劭宏, 等. 肝血管瘤射频消融致严重溶血和明显肾功能损害1例[J]. 中华普通外科杂志, 2010, 25(8): 691-692.
[12] 张龙, 李小龙, 高君, 等. 射频消融治疗巨大肝血管瘤致肾功能损害[J]. 中国医刊, 2014, 49(12): 76-78.
[13] Chapman, W.C., Debelak, J.P., Wright Pinson, C., et al. (2000) Hepatic Cryoablation, but Not Radiofrequency Ablation, Results in Lung Inflammation. Annals of Surgery, 231, 752-761. [Google Scholar] [CrossRef] [PubMed]
[14] Jansen, M.C., van Hillegersberg, R., Schoots, I.G., et al. (2010) Cryoablation Induces Greater Inflammatory and Coagulative Responses than Radiofrequency Ablation or Laser Induced Thermotherapy in a Rat Liver Model. Surgery, 147, 686-695. [Google Scholar] [CrossRef] [PubMed]
[15] Ng, K.K., Lam, C.M., Poon, R.T., et al. (2004) Comparison of Systemic Responses of Radiofrequency Ablation, Cryotherapy, and Surgical Resection in a Porcine Liver Model. Annals of Surgical Oncology, 11, 650-657. [Google Scholar] [CrossRef
[16] Jansen, M.C., van Wanrooy, S., van Hillegersberg, R., et al. (2008) Assessment of Systemic Inflammatory Response (SIR) in Patients Undergoing Radiofrequency Ablation or Partial Liver Resection for Liver Tumors. European Journal of Surgical Oncology, 34, 662-667. [Google Scholar] [CrossRef] [PubMed]
[17] Bulvik, B.E., Rozenblum, N., Gourevich, S., et al. (2016) Irreversi-ble Electroporation versus Radiofrequency Ablation: A Comparison of Local and Systemic Effects in a Small-Animal Model. Radiology, 280, 413-424. [Google Scholar] [CrossRef] [PubMed]
[18] Wang, S.H., Yang, M.M., Yang, X., et al. (2019) Endothelial Py-roptosis Underlies Systemic Inflammatory Response Following Radiofrequency Ablation of Hepatic Hemangiomas. Scandinavian Journal of Clinical and Laboratory Investigation, 79, 619-628. [Google Scholar] [CrossRef] [PubMed]
[19] Yang, X., Liu, J., Yang, M.-M., et al. (2020) Heme Is In-volved in the Systemic Inflammatory Response Following Radiofrequency Ablation of Hepatic Hemangiomas. European Journal of Gastroenterology & Hepatology, 32, 1200-1206. [Google Scholar] [CrossRef
[20] 彭振维, 庞雄昊, 陈敏山, 等. 多针双电极射频适形消融治疗肝癌16例报告[J]. 实用癌症杂志, 2007, 22(2): 171-174. [Google Scholar] [CrossRef
[21] Qu, C.M., Liu, H., Li, X.-Q., et al. (2020) Percutane-ous Ultrasound-Guided “Three-Step” Radiofrequency Ablation for Giant Hepatic Hemangioma (5 - 15 cm): A Safe and Effective New Technique. International Journal of Hyperthermia, 37, 212-219. [Google Scholar] [CrossRef] [PubMed]
[22] Wu, S.L., et al. (2021) Complications of Radiofrequency Ablation for Hepatic Hemangioma: A Multicenter Retrospective Analysis on 291 Cases. Frontiers in Oncology, 11, Arti-cle ID: 706619. [Google Scholar] [CrossRef] [PubMed]
[23] 刘江伟, 黄建钊, 孙倩, 等. 肝巨大血管瘤射频消融术后疗效观察[J]. 中国医学计算机成像杂志, 2016, 22(5): 440-443. [Google Scholar] [CrossRef
[24] Chen, L.B., et al. (2019) Safety and Effective of Lapa-roscopic Microwave Ablation for Giant Hepatic Hemangioma: A Retrospective Cohort Study. Annals of Medicine and Surgery, 39, 29-35. [Google Scholar] [CrossRef] [PubMed]
[25] 王翔翔, 刘洪, 张代忠, 等. 经皮射频消融治疗肝脏巨大血管瘤疗效观察[J]. 肝胆胰外科杂志, 2018, 30(5): 373-377. [Google Scholar] [CrossRef
[26] Gao, J., et al. (2016) Laparoscopic Radiofrequency Ablation for Large Subcapsular Hepatic Hemangiomas: Technical and Clinical Outcomes. PLOS ONE, 11, e0149755. [Google Scholar] [CrossRef] [PubMed]
[27] Van Tilborg, A.A., Nielsen, K., Scheffer, H.J., et al. (2013) Bi-polar Radiofrequency Ablation for Symptomatic Giant (> 10 cm) Hepatic Cavernous Haemangiomas: Initial Clinical Ex-perience. Clinical Radiology, 68, e9-e14. [Google Scholar] [CrossRef] [PubMed]
[28] Tang, X.Y., Wang, Z., Wang, T., et al. (2015) Efficacy, Safety and Feasibility of Ultrasound-Guided Percutaneous Microwave Ablation for Large Hepatic Hemangioma. Journal of Diges-tive Diseases, 16, 525-530. [Google Scholar] [CrossRef] [PubMed]