98岁患者大型脂溢性角化病1例并文献复习

A Case of Large Seborrheic Keratosis in a 98-Year-Old Patient and Literature Review

摘要: 患者女，98岁，右侧颞部长褐色皮疹20年。皮肤科情况：右侧颞部长新生物，呈花蕊状，大小约为30 * 35 * 10 mm³。采用活检钳法活检。组织病理学示：角化过度，表皮显著增厚以棘层肥厚明显，乳头瘤样增生可见，角质囊肿及基底样细胞分布明显。诊断：脂溢性角化病(棘层肥厚型)。治疗：外用药物并随访。本研究有三大特点：年龄大﹑皮损大﹑活检钳法，三者均极少见，并取得了满意结果；本研究技术操作简便，痛苦小，无风险，具有较高的应用价值，值得临床推广并进一步研究。

Abstract: The patient is a 98-year-old female with a brown rash on the right temporal lobe for 20 years. Skin lesion examination: There are new creatures growing in the right temporal region, which are in the shape of stamens, and the size is about 30 * 35 * 10 mm³. Biopsy was used by biopsy forceps method. Histopathology results showed hyperkeratosis, marked thickening of epidermis, marked acanthosis, papillomatous hyperplasia, and obvious distribution of keratinocysts and similar to epidermal ba-sal layer cells. Diagnosis: Seborrheic keratosis (spinous layer hypertrophy type). Treatment: Topical medication and follow-up. This study has three main characteristics: older age, larger skin lesions, and biopsy forceps method, all of which are extremely rare and have achieved satisfactory results. This research technique is easy to operate, less painful, and risk-free, and has high application value, which is worthy of clinical promotion and further research.