左心室血栓形成的研究进展
Research Progress of Left Ventricular Thrombus Formation
DOI: 10.12677/ACM.2024.141305, PDF,   
作者: 邱 倩, 娜几娜·吾格提*：新疆医科大学第一附属医院心脏中心心力衰竭科，新疆 乌鲁木齐
关键词: 左心室血栓/栓塞；预后；Left Ventricular Thrombus/Thromboembolism； Prognosis
摘要: 左心室血栓(left ventricular thrombus, LVT)是左心室功能不全患者的严重并发症，与不良预后相关。尽管有充分的介入和药物治疗，LVT脱落导致的血栓栓塞事件及并发症给患者的生活带来极大的不便，对患者远期预后和生存率造成不良影响，故近些年来逐渐成为心血管疾病研究的焦点，现对左心室血栓形成的最新研究进展做一综述。
Abstract: Left ventricular thrombosis is a serious complication in patients with left ventricular dysfunction and is associated with poor prognosis. Despite adequate intervention and drug treatment, throm-boembolism events and complications caused by left ventricular thrombus loss bring great incon-venience to the life of patients and adversely affect the long-term prognosis and survival rate of pa-tients. Therefore, they have gradually become the focus of cardiovascular disease research in recent years. This article reviews the latest research progress of left ventricular thrombosis.
文章引用：邱倩, 娜几娜·吾格提. 左心室血栓形成的研究进展[J]. 临床医学进展, 2024, 14(1): 2165-2172. https://doi.org/10.12677/ACM.2024.141305

参考文献

[1] 专家委员会中国血栓性疾病防治指南. 中国血栓性疾病防治指南[J]. 中华医学杂志, 2018, 98(36): 2861-2888.
[2] Yoon, C.H., Jung, H.W., Oh, I.Y., et al. (2013) Left Ventricular Thrombus and Subsequent Throm-boembolism, Comparison of Anticoagulation, Surgical Removal, and Antiplatelet Agents. Journal of Atherosclerosis and Thrombosis, 20, 73-93.
[3] McCarthy, C.P., Vaduganathan, M., McCarthy, K.J., et al. (2018) Left Ventricular Thrombus after Acute Myocardial Infarction Screening, Prevention, and Treatment. JAMA Cardiology, 3, 642-649. [Google Scholar] [CrossRef] [PubMed]
[4] Habash, F. and Vallurupalli, S. (2017) Challenges in Manage-ment of Left Ventricular Thrombus. Therapeutic Advances in Cardiovascular Disease, 11, 203-213. [Google Scholar] [CrossRef] [PubMed]
[5] Weinsaft, J.W., Kim, J., Medicherla, C.B., et al. (2016) Echocar-diographic Algorithm for Post-Myocardial Infarction LV Thrombus. JACC: Cardiovascular Imaging, 9, 505-515. [Google Scholar] [CrossRef] [PubMed]
[6] 翟玫, 黄丽燕, 王运红, 等. 扩张型心肌病合并心腔内血栓患者的临床特点分析[J]. 中国循环杂志, 2021, 36(6): 563-566.
[7] Benito, Y., Martinez-Legazpi, P., Rossini, L., et al. (2019) Age-Dependence of Flow Homeostasis in the Left Ventricle. Frontiers in Physiology, 10, Article 445666. [Google Scholar] [CrossRef] [PubMed]
[8] Wu, H.S., Dong, J.Z., Du, X., et al. (2022) Risk Factors for Left Ventricular Thrombus Formation in Patients with Dilated Cardiomyopathy. Seminars in Thrombosis and Hemostasis, 49, 673-678.
[9] Li, C., Lau, W.J., Qian, N.J., et al. (2022) Clinical Characteristics and Prognosis of Patients with Left Ventricular Thrombus in East China. Frontiers in Cardiovascular Medicine, 9, Article 944687. [Google Scholar] [CrossRef] [PubMed]
[10] Lattuca, B., Bouziri, N., Kerneis, M., et al. (2020) Antithrombotic Therapy for Patients with Left Ventricular Mural Thrombus. Journal of the American College of Cardiology, 75, 1676-1685. [Google Scholar] [CrossRef] [PubMed]
[11] Ntaios, G. (2020) Embolic Stroke of Undetermined Source. Journal of the American College of Cardiology, 75, 333-340. [Google Scholar] [CrossRef] [PubMed]
[12] 王雪芹, 张菲斐, 杨廷杰. 扩张型心肌病患者左心室球形度与附壁血栓的相关性分析[J]. 河南医学研究, 2020, 29(14): 2507-2510.
[13] 吴升良, 谢文, 卢睿, 等. D-D、vWF、血小板参数与NVAF患者并发血栓事件的关系研究[J]. 海南医学, 2023, 34(6): 841-845.
[14] 赵红丽, 刘丽敏, 张晓丹, 等. 非瓣膜病性心房颤动患者血栓前体蛋白与P选择素水平变化[J]. 中国循证心血管医学杂志, 2016, 8(11): 1326-1328.
[15] 王晓敏, 徐亚威, 毛云, 等. 扩张型心肌病患者合并左心室血栓的危险因素分析[J]. 医药论坛杂志, 2022, 43(22): 26-30.
[16] An, Z.X., Gao, Z.C., Wang, L.Y., et al. (2021) Prognostic Significance of B-Type Natriuretic Peptide in Patients with Left Ventricular Thrombus. Frontiers in Cardiovascular Medicine, 8, Article 667908. [Google Scholar] [CrossRef] [PubMed]
[17] 杨旭, 马春燕, 薛莉. 扩张型心肌病左室附壁血栓的危险因素分析[J]. 中国实用医刊, 2009, 36(5): 21-23.
[18] Liu, F.Z., Liao, H.T., Lin, W.D., et al. (2018) Predictive Effect of Hyperuricemia on Left Atrial Stasis in Non-Valvular Atrial Fibrillation Patients. International Journal of Cardiology, 258, 103-108. [Google Scholar] [CrossRef] [PubMed]
[19] 刘泽宇, 冯应君, 刘宣宣. 血小板与淋巴细胞比值在急性前壁心肌梗死后左室血栓形成中的临床价值[J]. 中国当代医药, 2022, 29(25): 18-21.
[20] 廖占玲, 安国印, 吴晶晶, 等. 中性粒细胞、淋巴细胞及血小板相关参数对ST段抬高型心肌梗死患者PCI术后不良事件发生的影响[J]. 中国医学创新, 2022, 19(7): 81-85.
[21] 王海斌, 高晓丽, 谢明, 等. 中性粒细胞与淋巴细胞的比值对老年急性ST段抬高型心肌梗死冠状动脉介入术远期预后的预测价值[J]. 中国实用内科杂志, 2022, 42(2): 146-150.
[22] Weinsaft, J.W., Kim, H.W., Crowley, A.L., et al. (2011) LV Thrombus Detection by Routine Echocardi-ography. JACC: Cardiovascular Imaging, 4, 702-712. [Google Scholar] [CrossRef] [PubMed]
[23] Srichai, M.B., Junor, C., Rodriguez, L.L., et al. (2006) Clinical, Imaging, and Pathological Characteristics of Left Ventricular Thrombus: A Comparison of Contrast-Enhanced Magnetic Resonance Imaging, Transthoracic Echocardiography, and Transesophageal Echocardiography with Surgical or Pathological Validation. American Heart Journal, 152, 75-84. [Google Scholar] [CrossRef] [PubMed]
[24] Doherty, J.U., Kort, S., Mehran, R., et al. (2019) ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2019 Appropriate Use Criteria for Multimodality Imag-ing in the Assessment of Cardiac Structure and Function in Nonvalvular Heart Disease. Journal of the American College of Cardiology, 73, 488-516. [Google Scholar] [CrossRef] [PubMed]
[25] Nakao, Y., Aono, J., Namiguchi, K., et al. (2020) Usefulness of Contrast Computed Tomography for Diagnosing Left Ventricular Thrombus before Impella Insertion. Journal of Cardi-ology Cases, 22, 291-293. [Google Scholar] [CrossRef] [PubMed]
[26] Chang, P., Xiao, J.Y., Hu, Z.H., et al. (2022) Imaging of Left Heart Intracardiac Thrombus: Clinical Needs, Current Imaging, and Emerging Cardiac Magnetic Resonance Techniques. Therapeutic Advances in Cardiovascular Disease, 16, 1-13. [Google Scholar] [CrossRef] [PubMed]
[27] Vandvik, P.O., Lincoff, A.M., Gore, J.M., et al. (2012) Primary and Secondary Prevention of Cardiovascular Disease. Chest, 141, E637S-E668S. [Google Scholar] [CrossRef] [PubMed]
[28] 武丽萍, 刘振良, 贾国渠, 等. 华法林在窦性心律左心功能不全扩张型心病患者中的有效性及安全性研究[J]. 双足与保健, 2017, 26(15): 79-80.
[29] Shantsila, E., Kozieł, M. and Lip, G.Y.H. (2021) Anticoagulation versus Placebo for Heart Failure in Sinus Rhythm. Cochrane Database of Systematic Reviews, 5, CD003336. [Google Scholar] [CrossRef] 
[30] Ponikowski, P., Voors, A.A., Anker, S.D., et al. (2016) 2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure of the European Society of Cardiol-ogy (ESC) Developed with the Special Contribution of the Heart Failure Association (HFA) of the ESC. European Heart Journal, 37, 2129-2200. [Google Scholar] [CrossRef] [PubMed]
[31] (2019) Correction to: 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients with Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Prac-tice Guidelines and the Heart Rhythm Society. Circulation, 140, e285. [Google Scholar] [CrossRef] 
[32] 中华医学会心血管病学分会, 中国心肌炎心肌病协作组. 中国扩张型心肌病诊断和治疗指南[J]. 临床心血管病杂志, 2018, 34(5): 421-434.
[33] 心肌病抗凝治疗中国专家共识专家组. 心肌病抗凝治疗中国专家共识[J]. 中国循环杂志, 2021, 36(12): 1148-1157.
[34] Levine, G.N., McEvoy, J.W., Fang, J.C., et al. (2022) Management of Patients at Risk for and with Left Ventricular Thrombus: A Sci-entific Statement from the American Heart Association. Circulation, 146, e205-e223. [Google Scholar] [CrossRef] 
[35] Lemaître, A.I., Picard, F., Maurin, V., et al. (2021) Clinical Profile and Midterm Prognosis of Left Ventricular Thrombus in Heart Failure. ESC Heart Failure, 8, 1333-1341. [Google Scholar] [CrossRef] [PubMed]
[36] Zhu, X.G., Wang, Z.H., Ferrari, M.W., et al. (2021) Anticoagulation in Cardiomyopathy: Unravelling the Hidden Threat and Challenging the Threat Individually. ESC Heart Failure, 8, 4737-4750. [Google Scholar] [CrossRef] [PubMed]
[37] 刘俊鹏, 李若宁, 张亚同, 等. 非维生素K拮抗剂口服抗凝药治疗非瓣膜性心房颤动相关左心耳血栓的单中心研究[J]. 中华心律失常学杂志, 2021, 25(6): 537-541.
[38] Ansell, J. (2012) Should Newer Oral Anticoagulants Be Used as First-Line Agents to Prevent Throm-boembolism in Patients with Atrial Fibrillation and Risk Factors for Stroke or Thromboembolism? Newer Oral Anticoag-ulants Should Be Used as First-Line Agents to Prevent Thromboembolism in Patients with Atrial Fibrillation and Risk Factors for Stroke or Thromboembolism Response. Circulation, 25, 165-170. [Google Scholar] [CrossRef] 
[39] Abdelnabi, M., Saleh, Y., Fareed, A., et al. (2021) Comparative Study of Oral Anticoagulation in Left Ventricular Thrombi (No-LVT Trial). Journal of the American Col-lege of Cardiology, 77, 1590-1592. [Google Scholar] [CrossRef] [PubMed]
[40] Chen, Y.M., Zhu, M., Wang, K., et al. (2022) Direct Oral Antico-agulants versus Vitamin K Antagonists for the Treatment of Left Ventricular Thrombus: An Updated Meta-Analysis of Cohort Studies and Randomized Controlled Trials. Journal of Cardiovascular Pharmacology, 79, 935-940. [Google Scholar] [CrossRef] 
[41] Daher, J., Da Costa, A., Hilaire, C., et al. (2021) Manage-ment of Left Ventricular Thrombi with Direct Oral Anticoagulants: Retrospective Comparative Study with Vitamin K Antagonists. Archives of Cardiovascular Diseases Supplements, 13, 74. [Google Scholar] [CrossRef] 
[42] Bolcal, C., Kadan, M., Kubat, E., et al. (2019) Surgical Treat-ment of a Left Ventricular Apical Thrombus via Robotic Surgery. Journal of Cardiac Surgery, 34, 216-218. [Google Scholar] [CrossRef] [PubMed]

为你推荐