促炎细胞因子与卒中后抑郁：讨论与思考

Pro-Inflammatory Cytokines and Post-Stroke Depression: Discussion and Thought

摘要: 脑卒中后抑郁症是脑卒中后最常见的精神疾病之一，属于创伤后应激障碍，是一种以持续情绪低落、兴趣下降为特征的心境障碍。它可能对患者生活的不同领域产生或大或小的负面影响。炎症作为机体生长发育和疾病进展中不可缺少的一部分，在脑卒中后抑郁中也起着重要作用，全身性炎症导致脑卒中风险增加和脑卒中后预后不良，这已被许多学者证实。当然，在炎症反应过程中有促炎细胞因子和炎性细胞因子的参与，促炎细胞因子可以帮助激活多种类型的免疫细胞，促进炎症的发生和发展，它们与抑郁症的病因密切相关，如果与其他诱发因素结合，反应会导致炎症过程延长，长期各轴不平衡，导致压力、疼痛、情绪变化，进而加重焦虑和抑郁。抑郁症的病理生理机制复杂多样，脑卒中后抑郁的机制尚未阐明，本文探讨促炎细胞因子与脑卒中后抑郁的关系，希望进一步解释脑卒中后抑郁的机制。

Abstract: Post-stroke depression is one of the most common mental illnesses after stroke, which belongs to post-traumatic stress disorder, and is a mood disorder characterized by persistent low mood and decreased interest. It can have a negative impact, large or small, on different areas of the patient’s life. As an indispensable part of the body’s growth and development and the progression of the dis-ease, inflammation also plays an important role in post-stroke depression, and systemic inflamma-tion leads to an increased risk of stroke and poor prognosis after stroke, which has been confirmed by many scholars. Of course, in the inflammatory response process has the participation of pro-inflammatory cytokines and inflammatory cytokines, pro-inflammatory cytokines can help ac-tivate a variety of types of immune cells to promote the occurrence and development of inflamma-tion, they are very closely related to the cause of depression, if combined with other predisposing factors, the response will lead to prolonged inflammatory processes, long-term imbalance of various axes, resulting in stress, pain, mood changes, and then aggravate anxiety and depression. The pathophysiological mechanism of depression is complex and diverse, and the mechanism of post-stroke depression has not yet been elucidated, this article discusses the relationship between pro-inflammatory cytokines and post-stroke depression, hoping to further explain the mechanism of post-stroke depression.