内皮细胞焦亡与动脉粥样硬化的关系及其中药防治研究进展
The Relationship between Endothelial Cell Pyroptosis and Atherosclerosis and Research Progress of Chinese Medicine against Atherosclerosis
DOI: 10.12677/ACM.2024.142323, PDF,    国家自然科学基金支持
作者: 胡雨蝶, 杨 阳：贵州中医药大学基础医学院，贵州 贵阳；田维毅*：贵州中医药大学副校长，贵州 贵阳
关键词: 内皮细胞焦亡；动脉粥样硬化；中药；Endothelial Cells Pyroptosis； Atherosclerosis； Medicinal Herb
摘要: 近年来，动脉粥样硬化作为一种慢性炎症性血管疾病对人类生命产生严重威胁因而成为当代研究热点之一，其发生主要是由于动脉内脂质沉积纤维斑块形成，内皮细胞巨噬细胞等炎性细胞功能障碍导致血管壁硬化血栓形成。与此同时，内皮细胞功能障碍被认为是动脉粥样硬化损伤的始动因素，内皮细胞死亡促炎因子被大量释放加速动脉粥样硬化发展进程。细胞焦亡是近年来细胞死亡方向的研究热点之一，在动脉粥样硬化研究进展中内皮细胞焦亡便是最新热点之一。中药单体或单体有效活性成分都通过发挥自身多靶点、多疗效优势在治疗动脉粥样硬化方面取得了不菲成绩。
Abstract: In recent years, atherosclerosis, as a chronic inflammatory vascular disease, has increasingly be-come one of the hot spots in contemporary research because of its serious threat to human life. Its occurrence is mainly due to the dysfunction of inflammatory cells such as lipid deposition in arter-ies, fibrous plaque formation and endothelial macrophages, which leads to the formation of vascular wall sclerosis and thrombosis. At the same time, endothelial dysfunction is considered to be the ini-tial factor of atherosclerosis injury, and endothelial cell death pro-inflammatory factors are released in large quantities to accelerate the development of atherosclerosis. Cell apoptosis is one of the re-search hotspots in the direction of cell death in recent years, and endothelial cell pyroptosis has gradually become one of the research hotspots of atherosclerosis. Traditional Chinese medicine monomer and monomer active components have made great achievements in the treatment of atherosclerosis by giving full play to their multi-target and multi-therapeutic advantages.
文章引用：胡雨蝶, 杨阳, 田维毅. 内皮细胞焦亡与动脉粥样硬化的关系及其中药防治研究进展[J]. 临床医学进展, 2024, 14(2): 2301-2307. https://doi.org/10.12677/ACM.2024.142323

参考文献

[1] Roth, G.A., Mensah, G.A., Johnson, C.O., et al. (2020) Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update from the GBD 2019 Study. Journal of the American College of Cardiology, 76, 2982-3021. [Google Scholar] [CrossRef] [PubMed]
[2] Jiang, F., Chen, Q., Wang, W., et al. (2020) Hepatocyte Derived Extracellular Vesicles Promote Endothelial Inflammation and Atherogenesis via microRNA-1. Journal of Hepatology, 72, 156-166. [Google Scholar] [CrossRef] [PubMed]
[3] Nasiri-Ansari, N., Androutsakos, T., Flessa, C.M., et al. (2022) Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review. Cells, 11, Article No. 2511. [Google Scholar] [CrossRef] [PubMed]
[4] Osonoi, Y., Mita, T., Azuma, K., Nakajima, K., Masuyama, A., Goto, H., et al. (2018) Defective Autophagy in Vascular Smooth Muscle Cells Enhances Cell Death and Atherosclerosis. Autophagy, 14, 1991-2006. [Google Scholar] [CrossRef] [PubMed]
[5] Libby, P., Ridker, P.M. and Hansson, G.K. (2011) Progress and Challenges in Translating the Biology of Atherosclerosis. Nature, 473, 317-325. [Google Scholar] [CrossRef] [PubMed]
[6] Kadlec, A.O., Chabowski, D.S., Ait-Aissa, K., et al. (2016) Role of PGC-1α in Vascular Regulation: Implications for Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 36, 1467-1474. [Google Scholar] [CrossRef] 
[7] Gimbrone, M.A. and García-Cardeña, G. (2016) Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circulation Research, 118, 620-636. [Google Scholar] [CrossRef] 
[8] Heitzer, T., Schlinzig, T., Krohn, K., et al. (2001) Endo-thelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients with Coronary Artery Disease. Cir-culation, 104, 2673-2678. [Google Scholar] [CrossRef] [PubMed]
[9] 刘梨, 龚后武, 张建影, 等. 中医药治疗颈动脉粥样硬化斑块临床疗效的Meta分析[J]. 中医药学报, 2015, 43(3): 20-24.
[10] 赵立凤, 于红红, 田维毅. 中药单体调控血管内皮细胞自噬干预动脉粥样硬化的研究进展[J]. 中华中医药学刊, 2021, 39(11): 117-120.
[11] 柴钰, 金翠柳, 凌望, 等. 血管内皮细胞焦亡在动脉粥样硬化发生、发展中的作用及机制研究进展[J]. 医学研究杂志, 2021, 50(9): 147-150+172.
[12] 雷紫琴, 栾飞, 高铭, 等. 细胞焦亡与心血管疾病的关系及中医药防治研究进展[J]. 中国中药杂志, 2023, 48(7): 1779-1791.
[13] Kong, P., Cui, Z.-Y., Huang, X.-F., et al. (2022) Inflammation and Atheroscle-rosis: Signaling Pathways and Therapeutic Intervention. Signal Transduction and Targeted Therapy, 7, Article No. 131. [Google Scholar] [CrossRef] [PubMed]
[14] Ley, K., Miller, Y.I. and Hedrick, C.C. (2011) Monocyte and Macrophage Dynamics during Atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 1506-1516. [Google Scholar] [CrossRef] 
[15] 李容, 王新文, 杨晓辉, 等. 细胞命运之终点——细胞死亡[J]. 科学通报, 2016, 61(18): 1983-1987.
[16] Grootjans, S., Vanden, Berghe, T. and Vandenabeele, P. (2017) Initia-tion and Execution Mechanisms of Necroptosis: An Overview. Cell Death & Differentiation, 24, 1184-1195. [Google Scholar] [CrossRef] [PubMed]
[17] Xing, S.-S., Yang, J., Li, W., et al. (2020) Salidroside Decreases Athero-sclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis. Inflammation, 43, 433-440. [Google Scholar] [CrossRef] [PubMed]
[18] Zhang, Y., Chen, X., Gueydan, C. and Han, J. (2018) Plasma Membrane Changes during Programmed Cell Deaths. Cell Research, 28, 9-21. [Google Scholar] [CrossRef] [PubMed]
[19] 赵为陈, 江俊麟. 细胞焦亡在血管内皮细胞功能障碍中的研究进展[J]. 重庆医学, 2020, 49(15): 2577-2582.
[20] Liu, X., Zhang, Z., Ruan, J., et al. (2016) Inflammasome-Activated Gasdermin D Causes Pyroptosis by Forming Membrane Pores. Nature, 535, 153-158. [Google Scholar] [CrossRef] [PubMed]
[21] 杜会君, 杨红晓, 白俊彩, 等. 细胞焦亡与心血管疾病[J]. 国际心血管病杂志, 2022, 49(2): 92-95.
[22] 刘孜琦, 聂妍琦, 傅旖灵, 等. 基于NLRP3炎症小体探讨电针对脑缺血再灌注损伤大鼠细胞焦亡的影响[J]. 中国中医药信息杂志, 2022, 29(10): 84-89.
[23] Guo, H., Callaway, J.B. and Ting, J.P.Y. (2015) Inflammasomes: Mechanism of Action, Role in Disease, and Therapeutics. Nature Medicine, 21, 677-687. [Google Scholar] [CrossRef] [PubMed]
[24] Chen, Y., He, H., Jiang, H., et al. (2020) Discovery and Optimization of 4-Oxo-2-thioxo-thiazolidinones as NOD-Like Receptor (NLR) Family, Pyrin Domain-Containing Protein 3 (NLRP3) Inhibitors. Bioorganic & Medicinal Chemistry Letters, 30, Article ID: 127021. [Google Scholar] [CrossRef] [PubMed]
[25] Yin, Y., Li, X., Sha, X., et al. (2015) Early Hyperlipidemia Pro-motes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 35, 804-816. [Google Scholar] [CrossRef] 
[26] 赵权威, 李辉, 刘大男, 等. 达格列净减轻氧化低密度脂蛋白诱导的内皮细胞焦亡和功能障碍[J]. 中国组织工程研究, 2024, 28(1): 80-85.
[27] Heeschen, C., Jang, J.J., Weis, M., et al. (2001) Nicotine Stimulates Angiogenesis and Promotes Tumor Growth and Atherosclerosis. Nature Medicine, 7, 833-839. [Google Scholar] [CrossRef] [PubMed]
[28] Wu, X., Zhang, H., Qi, W., et al. (2018) Nicotine Pro-motes Atherosclerosis via ROS-NLRP3-Mediated Endothelial Cell Pyroptosis. Cell Death & Disease, 9, Article No. 171. [Google Scholar] [CrossRef] [PubMed]
[29] Jiang, X., Ma, C., Gao, Y., et al. (2023) Tongxinluo Attenuates Atherosclerosis by Inhibiting ROS/NLRP3/Caspase-1- Mediated Endothelial Cell Pyroptosis. Journal of Ethnopharma-cology, 304, Article ID: 116011. [Google Scholar] [CrossRef] [PubMed]
[30] 袁育林. 姜黄素抑制NLRP3介导的细胞焦亡改善内皮细胞功能[D]: [硕士学位论文]. 衡阳: 南华大学, 2022.
[31] 杨佳乐, 沈祥春. 灯盏花乙素通过抑制NLRP3/caspase-1信号通路改善LPS+ATP诱导内皮细胞炎症反应和细胞焦亡[J]. 中国药理学通报, 2022, 38(8): 1196-1201.
[32] 吴树宁, 王凯, 施思, 等. 大黄素预处理对LPS/ATP诱导的人脐静脉内皮细胞焦亡的影响[J]. 山西医科大学学报, 2019, 50(4): 410-414.
[33] 张艳, 周庆兵, 徐凤芹. 栀子苷防治动脉粥样硬化的分子生物学分析[J]. 世界中西医结合杂志, 2021, 16(8): 1373-1378.
[34] 王复婧, 黄小飞, 赵丹丹, 等. 栀子苷通过PI3K通路抑制OX-LDL诱导HUVEC中KLF2表达[J]. 中药药理与临床, 2018, 34(1): 53-56.
[35] He, J., Deng, Y., Ren, L., et al. (2023) Isoliquiritigenin from Licorice Flavonoids Attenuates NLRP3-Mediated Pyroptosis by SIRT6 in Vascular Endothelial Cells. Journal of Ethnopharmacology, 303, Article ID: 115952. [Google Scholar] [CrossRef] [PubMed]

为你推荐