白细胞介素-10在缺血性卒中中的作用
The Role of Interleukin-10 in Ischemic Stroke
摘要: 脑动脉闭塞后的缺血性卒中是造成全球慢性残疾的主要原因,也是全球第二大死亡原因。白细胞介素-10 (IL-10)是一种主要由Th2细胞和单核细胞分泌的免疫调节细胞因子。它对缺血性脑卒中的神经保护作用一直是研究热点。IL-10具有较强的免疫抑制活性。它可以抑制IL-2、IFN-g和促炎因子的产生和释放,降低免疫受体的表达,抑制人Th2细胞,导致细胞增殖,细胞因子产生减少。IL-10与IL-10受体(IL-10 R)结合以减少炎症并限制细胞凋亡。这些作用使其在脑缺血的保护中具有重要的作用。本文就IL-10在缺血性脑卒中中的多种作用作一综述。
Abstract: Ischemic stroke following cerebral artery occlusion is the leading cause of chronic disability world-wide and the second leading cause of death worldwide. Interleukin-10 (IL-10) is an immunomodu-latory cytokine secreted mainly by Th2 cells and monocytes. Its neuroprotective effect on ischemic stroke has been a focus of research. IL-10 has strong immunosuppressive activity. It can inhibit the production and release of IL-2, IFN-g and pro-inflammatory factors, reduce the expression of im-mune receptors, inhibit human Th2 cells, resulting in cell proliferation and reduced cytokine pro-duction. IL-10 binds to the IL-10 receptor (IL-10 R) to reduce inflammation and limit apoptosis. These effects make it play an important role in the protection of cerebral ischemia. This article re-views the various roles of IL-10 in ischemic stroke.
文章引用:宋钊, 高博涛. 白细胞介素-10在缺血性卒中中的作用[J]. 临床医学进展, 2024, 14(2): 2368-2372. https://doi.org/10.12677/ACM.2024.142332

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